Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Teneurin-4

Gene

tenm4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May play a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation of oligodendrocytes and myelination of axons. May function as a cellular signal transducer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Teneurin-4
Short name:
Ten-4
Alternative name(s):
Protein Odd Oz/ten-m homolog 4
Tenascin-M4
Short name:
Ten-m4
Teneurin transmembrane protein 4
Gene namesi
Name:tenm4
Synonyms:odz4, tnm4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990714-20. tenm4.

Subcellular locationi

  • Cell membrane By similarity; Single-pass membrane protein Sequence analysis
  • Cell projection By similarity
  • Nucleus By similarity
  • Cytoplasm By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown of the gene in embryos resulted in a modest reduction of myelin in the brain and an increase in the number of small-diameter neuronal axons with aberrant branching along the notochord.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595101 – 2824Teneurin-4Add BLAST2824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi536N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi637 ↔ 647PROSITE-ProRule annotation
Disulfide bondi641 ↔ 652PROSITE-ProRule annotation
Disulfide bondi654 ↔ 663PROSITE-ProRule annotation
Disulfide bondi672 ↔ 683PROSITE-ProRule annotation
Disulfide bondi685 ↔ 694PROSITE-ProRule annotation
Disulfide bondi701 ↔ 712PROSITE-ProRule annotation
Disulfide bondi706 ↔ 717PROSITE-ProRule annotation
Disulfide bondi719 ↔ 728PROSITE-ProRule annotation
Disulfide bondi733 ↔ 744PROSITE-ProRule annotation
Disulfide bondi738 ↔ 749PROSITE-ProRule annotation
Disulfide bondi751 ↔ 760PROSITE-ProRule annotation
Disulfide bondi771 ↔ 784PROSITE-ProRule annotation
Disulfide bondi786 ↔ 795PROSITE-ProRule annotation
Glycosylationi789N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi800 ↔ 810PROSITE-ProRule annotation
Disulfide bondi804 ↔ 815PROSITE-ProRule annotation
Disulfide bondi817 ↔ 826PROSITE-ProRule annotation
Disulfide bondi831 ↔ 841PROSITE-ProRule annotation
Disulfide bondi835 ↔ 846PROSITE-ProRule annotation
Disulfide bondi848 ↔ 857PROSITE-ProRule annotation
Disulfide bondi862 ↔ 872PROSITE-ProRule annotation
Disulfide bondi866 ↔ 881PROSITE-ProRule annotation
Disulfide bondi883 ↔ 892PROSITE-ProRule annotation
Glycosylationi1002N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1647N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1664N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1760N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1796N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1854N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1939N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2040N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2243N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2701N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9W7R3.
PRIDEiQ9W7R3.

Expressioni

Tissue specificityi

Mainly expressed in the brain.1 Publication

Developmental stagei

During gastrulation, expressed throughout the embryo very faintly. Expressed along the anterior margin of the neural plate. Later, this marginal expression extends caudally, and eventually restricted only to the caudal neural plate. At 14 h post-fertilization, it is expressed in the brain. Expressed in the rhombomere 5 (r5) and more strongly in r6. Expressed in the rostral diencephalon with weak expression in the optic vesicles, and a region covering the mesencephalon and the midbrain/hindbrain boundary (MHB) in a gradient manner with stronger expression at its posterior end. At 17 hpf, expressed weakly in the dorsal edge of the most caudal part of the neural tube. Faint expression is detected in several neurons located at ventral and dorsal parts of the caudal spinal cord.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016395.

Structurei

3D structure databases

ProteinModelPortaliQ9W7R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 412Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST412
Domaini633 – 664EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini665 – 695EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini697 – 729EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini730 – 761EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Domaini763 – 796EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini797 – 828EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Domaini829 – 858EGF-like 7PROSITE-ProRule annotationAdd BLAST30
Domaini859 – 893EGF-like 8PROSITE-ProRule annotationAdd BLAST35
Repeati1278 – 1321NHL 1Add BLAST44
Repeati1326 – 1363NHL 2Add BLAST38
Repeati1389 – 1433NHL 3Add BLAST45
Repeati1448 – 1499NHL 4Add BLAST52
Repeati1522 – 1552NHL 5Add BLAST31
Repeati1578 – 1621NHL 6Add BLAST44
Repeati1631 – 1650YD 1Add BLAST20
Repeati1667 – 1687YD 2Add BLAST21
Repeati1730 – 1749YD 3Add BLAST20
Repeati1750 – 1772YD 4Add BLAST23
Repeati1942 – 1961YD 5Add BLAST20
Repeati1983 – 2001YD 6Add BLAST19
Repeati2002 – 2022YD 7Add BLAST21
Repeati2029 – 2046YD 8Add BLAST18
Repeati2047 – 2068YD 9Add BLAST22
Repeati2069 – 2086YD 10Add BLAST18
Repeati2089 – 2109YD 11Add BLAST21
Repeati2112 – 2132YD 12Add BLAST21
Repeati2140 – 2159YD 13Add BLAST20
Repeati2165 – 2182YD 14Add BLAST18
Repeati2183 – 2209YD 15Add BLAST27
Repeati2211 – 2224YD 16Add BLAST14
Repeati2225 – 2248YD 17Add BLAST24
Repeati2251 – 2271YD 18Add BLAST21
Repeati2272 – 2292YD 19Add BLAST21
Repeati2294 – 2314YD 20Add BLAST21
Repeati2326 – 2346YD 21Add BLAST21
Repeati2348 – 2368YD 22Add BLAST21
Repeati2394 – 2435YD 23Add BLAST42

Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated
Contains 8 EGF-like domains.PROSITE-ProRule annotation
Contains 6 NHL repeats.Curated
Contains 1 teneurin N-terminal domain.PROSITE-ProRule annotation
Contains 23 YD repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4659. Eukaryota.
ENOG410XQQD. LUCA.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ9W7R3.
PhylomeDBiQ9W7R3.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011041. Quinoprot_gluc/sorb_DH.
IPR022385. Rhs_assc_core.
IPR031325. RHS_repeat.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF9. PTHR11219:SF9. 3 hits.
PfamiPF05593. RHS_repeat. 1 hit.
PF06484. Ten_N. 1 hit.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF50952. SSF50952. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 3 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 4 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W7R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKERRPYR SLTSRRDTER RYTSSSADSE DGKINPKSYS SSETLKAFDQ
60 70 80 90 100
DSRLAYGSRV KDLVHHEADE FSRQGPDFSL RDMAFGDPVP PHMGAYRTEM
110 120 130 140 150
GLPHRDYSVS VASDADTETD GIMSPEHAVR LWGRSNTKSG RSSCLFSRAN
160 170 180 190 200
SNLTLTDTEH ENTENGPPLH CSSASSSPVD SPYPPPSHAA NQSQGRLLGN
210 220 230 240 250
SGAQAGRDSE SEDEFGPNSF LVKTGSGNVC TPAAATANEG SFQNHSRLRT
260 270 280 290 300
PPLPLFHSHS PSQHHTASIG SLSRSNYTQR SNPSPAPTDS SAPNEGPTSA
310 320 330 340 350
QDSSSAQDNW LLNSNVPLET RNIAKQTFLE TLQDNFIEMD ILATARRDGA
360 370 380 390 400
YTDGHFLFKP GGTSPLYCTT SPGYPLTSST VYSPPPRPLP RNTFSRPAFS
410 420 430 440 450
LKKPYKHCNW KCAALSAILI SVTLVFLLAY FIAMHLFGLN WHLQPVQRQI
460 470 480 490 500
YQLTEDNTSG LHLPTDLGLP PLGNTGLEFP DRGSRDDGKL DGFFPEDSFI
510 520 530 540 550
DMGEIDVGRK VAQLIPPGIF WRSQVFIDHP MYLKFNVSLS KDALVGIYGR
560 570 580 590 600
RGLPPSHTQF DFVELLDGRR LLSQGLPGLD GPPFPAQQRS LVPITSHDTG
610 620 630 640 650
CIQYMDSGIW HLAVYNDGKE TEQVSFLTTA IDSIDDCPSN CFGNGDCVSG
660 670 680 690 700
NCHCFPGFRG PDCSRASCPV LCSGNGQYLK GRCMCHSGWK GSECDVPTNQ
710 720 730 740 750
CIDITCSGHG TCIVGTCICN PSYKGENCEE VDCLDPTCSG RGVCVRGECH
760 770 780 790 800
CFVGWGGPGC ESPRASCMEQ CSGHGSFLAD TNTCNCDHNW TGHDCSTELC
810 820 830 840 850
AADCGGHGIC VAGSCRCDEG WMGTGCEQRA CHPRCSEHGT CKDGKCECSP
860 870 880 890 900
GWNGEHCTIE GCPGLCNGNG RCTLGNNGWY CVCQLGWRGA GCDTSMETAC
910 920 930 940 950
SDGKDNDGDG LTDCMDPDCC LQASCHTTSL CVGSPDPLDI IQETQISSSL
960 970 980 990 1000
STLQSFYQRI HFLVGRDSTH VIPDVNPFDG IHACVIRGQV VTSDGTPLVG
1010 1020 1030 1040 1050
VNISFINKPA YGYTITRQDG SFDLVSNGGV AIGLRFERAP FITQEHTLWL
1060 1070 1080 1090 1100
PWGRFFVMDT IVMRHEVNDI PSCDLSSFTR PMPIVLPAPL TAFAGTCPER
1110 1120 1130 1140 1150
GIVVPEIQTL QEEVRIPGTD MRLGYLSSRT SGYKSLLRIT LTHSTIPFSL
1160 1170 1180 1190 1200
MKVHLMVAVE GRLFRKWFSA APNLSYDFVW DKTDVYSQKV YGLSEAFVSV
1210 1220 1230 1240 1250
GFEYESCPDL ILWEKRTAVL QGYETTASNL GGWSVDKHHA LNIQSGILHK
1260 1270 1280 1290 1300
GNGENIFISQ QPPVIGSIMG NGRRRSISCP SCNGLADGNK LLAPVALACG
1310 1320 1330 1340 1350
SDGSLYVGDF NYVRRIFTTG NVTSVLELSN SPAHKYYLAT SPVSGWLYLS
1360 1370 1380 1390 1400
DTSSRKVFKV KSLYAVKDVA KNLELVAGTG DQCLPYDETR CGDGGKAVEA
1410 1420 1430 1440 1450
TLTNPRGITV DKYGVIFFVD GTMIRRIDQN GIISTLLGFN DLTSARPLSC
1460 1470 1480 1490 1500
DSVMDISQVR LEWPTDLAVS PMDNSLYVLD NNVVLQISEN HQVRIVAGRP
1510 1520 1530 1540 1550
MHCQVPGLDH FLVSKIAIHA TLESANALAV SHNGLLYIAE SDEKKINRVR
1560 1570 1580 1590 1600
QVSTNGEISL LAGAPSGCDC KNDANCDCYS GDDGYAKDAK LNAPSSLAVS
1610 1620 1630 1640 1650
PDGELFIADL GNIRIRYVRR NKAFLNPLNM YEISSPIDDE LYLFDVNASH
1660 1670 1680 1690 1700
VFTQSLTTGD YLYNFTYSGE GDLSSITDKN KNRVSIRRDS TGLPLWLMGP
1710 1720 1730 1740 1750
DGQTFWFTMG TNNALKSVAA QGQEIAVMTY HGSSGLLATK SNEDGWSTFY
1760 1770 1780 1790 1800
EYDNYGRLTN VTYPTGRVSS YRTDSDSTVR VQTEGSNKED ITVTTNLSAS
1810 1820 1830 1840 1850
GTFYTLMQDQ VKNSYYIGLD GSLRLVLANG MEVSLHTEPH LLSGTVNPTI
1860 1870 1880 1890 1900
SKRNVTLPID NGLNLVEWRQ RKEQARGQVT VYGRRLRVHN RNLLSMDFDR
1910 1920 1930 1940 1950
VTRTEKVYDD HRKFTLRIHY DHAGRPTLWA PSSRLNGVNV TYSPGGHIAG
1960 1970 1980 1990 2000
IQRGTMSVRM EYDQNGRITS KIFADGKSWS YTYLEKSMVL LLYSQRQYIF
2010 2020 2030 2040 2050
EFDKNDRLSS VTMPNVARQT LETTRSIGYY RNTYRPPEGN ATVLQDYSED
2060 2070 2080 2090 2100
GLLLQTIHQG TGRRVIYKYG KLSRLLEILY DTTRIAFSYD ESAGMLKTVG
2110 2120 2130 2140 2150
LQSEGFACTI RYRQIGPLID RQIFRFSEEG MVNARFDYNY DNSFRVTSMQ
2160 2170 2180 2190 2200
AVINETPLPI DLYRYDDVSG KTEQFGKFGV IYYDINQIIT TAVMTHTKHF
2210 2220 2230 2240 2250
DAYGRVKEVQ YEIFRSLMYW MMVQFDNMGR VVAKELKVGP YANTTRYAYE
2260 2270 2280 2290 2300
YDADGQLQVV SINDKPLWRY SYDLNGNLHL LSPGNSARLT PLRYDIRDRI
2310 2320 2330 2340 2350
TRLGDVQYRL DEDGFLRQRG NDFFEYNSAG LLVKTYNKVN GWTIKYRYDG
2360 2370 2380 2390 2400
LGRRVSSRST QGHHLQFFYA DLSSPTRVTH MYNHSSSEIT SLYYDLQGHL
2410 2420 2430 2440 2450
FAMELSSGDE FYVACDNIGT PLAVFSGAGL MIKQILHTAF GEVYLDSNPS
2460 2470 2480 2490 2500
FQLVIGYQGG LYEPLTKLVH MGRRDYDVLA GRWTTPDHDI RKRLNSDNIV
2510 2520 2530 2540 2550
PFNLYMFKNN NPLSNSQETK CYMTDVNSWL VTFGFQLYNV IPGYRKPVTD
2560 2570 2580 2590 2600
AMEPSYELVH TQIKTQEWDS TKSVLGVQCE VQRQLKSFVR LERFGQIYSA
2610 2620 2630 2640 2650
SDSGCPPTPL HTLFATGTSL FGKGVKVAIR EGRVEADIIS LANEDGRRIA
2660 2670 2680 2690 2700
AVLDKASYLQ DLHFTIAGLD THYFVKSGLV EGDLSLLGMT VGQRTLETGV
2710 2720 2730 2740 2750
NVTVSQVNMV LGGRSRRITD IQMQYGTLSL NVRYGSSVDE EKVRVLELAR
2760 2770 2780 2790 2800
QRAVATAWAH ERHRLRQGEE GSRAWTDGER QQLLSSGRVQ GYEGFYIVSV
2810 2820
DQFPELTDNI NNVHFWRQTE MGRR
Length:2,824
Mass (Da):313,506
Last modified:November 1, 1999 - v1
Checksum:i27007746DD34E356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026980 mRNA. Translation: BAA81893.1.
UniGeneiDr.81257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026980 mRNA. Translation: BAA81893.1.
UniGeneiDr.81257.

3D structure databases

ProteinModelPortaliQ9W7R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016395.

Proteomic databases

PaxDbiQ9W7R3.
PRIDEiQ9W7R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990714-20. tenm4.

Phylogenomic databases

eggNOGiKOG4659. Eukaryota.
ENOG410XQQD. LUCA.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ9W7R3.
PhylomeDBiQ9W7R3.

Miscellaneous databases

PROiQ9W7R3.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011041. Quinoprot_gluc/sorb_DH.
IPR022385. Rhs_assc_core.
IPR031325. RHS_repeat.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF9. PTHR11219:SF9. 3 hits.
PfamiPF05593. RHS_repeat. 1 hit.
PF06484. Ten_N. 1 hit.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF50952. SSF50952. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 3 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 4 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEN4_DANRE
AccessioniPrimary (citable) accession number: Q9W7R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.