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Protein

Teneurin-4

Gene

tenm4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May play a role in the establishment of the anterior-posterior axis during gastrulation. May regulate the differentiation of oligodendrocytes and myelination of axons. May function as a cellular signal transducer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Teneurin-4
Short name:
Ten-4
Alternative name(s):
Protein Odd Oz/ten-m homolog 4
Tenascin-M4
Short name:
Ten-m4
Teneurin transmembrane protein 4
Gene namesi
Name:tenm4
Synonyms:odz4, tnm4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990714-20. tenm4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei417 – 43721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28242824Teneurin-4PRO_0000259510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi637 ↔ 647PROSITE-ProRule annotation
Disulfide bondi641 ↔ 652PROSITE-ProRule annotation
Disulfide bondi654 ↔ 663PROSITE-ProRule annotation
Disulfide bondi672 ↔ 683PROSITE-ProRule annotation
Disulfide bondi685 ↔ 694PROSITE-ProRule annotation
Disulfide bondi701 ↔ 712PROSITE-ProRule annotation
Disulfide bondi706 ↔ 717PROSITE-ProRule annotation
Disulfide bondi719 ↔ 728PROSITE-ProRule annotation
Disulfide bondi733 ↔ 744PROSITE-ProRule annotation
Disulfide bondi738 ↔ 749PROSITE-ProRule annotation
Disulfide bondi751 ↔ 760PROSITE-ProRule annotation
Disulfide bondi771 ↔ 784PROSITE-ProRule annotation
Disulfide bondi786 ↔ 795PROSITE-ProRule annotation
Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi800 ↔ 810PROSITE-ProRule annotation
Disulfide bondi804 ↔ 815PROSITE-ProRule annotation
Disulfide bondi817 ↔ 826PROSITE-ProRule annotation
Disulfide bondi831 ↔ 841PROSITE-ProRule annotation
Disulfide bondi835 ↔ 846PROSITE-ProRule annotation
Disulfide bondi848 ↔ 857PROSITE-ProRule annotation
Disulfide bondi862 ↔ 872PROSITE-ProRule annotation
Disulfide bondi866 ↔ 881PROSITE-ProRule annotation
Disulfide bondi883 ↔ 892PROSITE-ProRule annotation
Glycosylationi1002 – 10021N-linked (GlcNAc...)Sequence analysis
Glycosylationi1173 – 11731N-linked (GlcNAc...)Sequence analysis
Glycosylationi1321 – 13211N-linked (GlcNAc...)Sequence analysis
Glycosylationi1647 – 16471N-linked (GlcNAc...)Sequence analysis
Glycosylationi1664 – 16641N-linked (GlcNAc...)Sequence analysis
Glycosylationi1760 – 17601N-linked (GlcNAc...)Sequence analysis
Glycosylationi1796 – 17961N-linked (GlcNAc...)Sequence analysis
Glycosylationi1854 – 18541N-linked (GlcNAc...)Sequence analysis
Glycosylationi1939 – 19391N-linked (GlcNAc...)Sequence analysis
Glycosylationi2040 – 20401N-linked (GlcNAc...)Sequence analysis
Glycosylationi2243 – 22431N-linked (GlcNAc...)Sequence analysis
Glycosylationi2383 – 23831N-linked (GlcNAc...)Sequence analysis
Glycosylationi2701 – 27011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9W7R3.
PRIDEiQ9W7R3.

Expressioni

Tissue specificityi

Mainly expressed in the brain.1 Publication

Developmental stagei

During gastrulation, expressed throughout the embryo very faintly. Expressed along the anterior margin of the neural plate. Later, this marginal expression extends caudally, and eventually restricted only to the caudal neural plate. At 14 h post-fertilization, it is expressed in the brain. Expressed in the rhombomere 5 (r5) and more strongly in r6. Expressed in the rostral diencephalon with weak expression in the optic vesicles, and a region covering the mesencephalon and the midbrain/hindbrain boundary (MHB) in a gradient manner with stronger expression at its posterior end. At 17 hpf, expressed weakly in the dorsal edge of the most caudal part of the neural tube. Faint expression is detected in several neurons located at ventral and dorsal parts of the caudal spinal cord.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016395.

Structurei

3D structure databases

ProteinModelPortaliQ9W7R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 412412Teneurin N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini633 – 66432EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini665 – 69531EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini697 – 72933EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini730 – 76132EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini763 – 79634EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini797 – 82832EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini829 – 85830EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini859 – 89335EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Repeati1278 – 132144NHL 1Add
BLAST
Repeati1326 – 136338NHL 2Add
BLAST
Repeati1389 – 143345NHL 3Add
BLAST
Repeati1448 – 149952NHL 4Add
BLAST
Repeati1522 – 155231NHL 5Add
BLAST
Repeati1578 – 162144NHL 6Add
BLAST
Repeati1631 – 165020YD 1Add
BLAST
Repeati1667 – 168721YD 2Add
BLAST
Repeati1730 – 174920YD 3Add
BLAST
Repeati1750 – 177223YD 4Add
BLAST
Repeati1942 – 196120YD 5Add
BLAST
Repeati1983 – 200119YD 6Add
BLAST
Repeati2002 – 202221YD 7Add
BLAST
Repeati2029 – 204618YD 8Add
BLAST
Repeati2047 – 206822YD 9Add
BLAST
Repeati2069 – 208618YD 10Add
BLAST
Repeati2089 – 210921YD 11Add
BLAST
Repeati2112 – 213221YD 12Add
BLAST
Repeati2140 – 215920YD 13Add
BLAST
Repeati2165 – 218218YD 14Add
BLAST
Repeati2183 – 220927YD 15Add
BLAST
Repeati2211 – 222414YD 16Add
BLAST
Repeati2225 – 224824YD 17Add
BLAST
Repeati2251 – 227121YD 18Add
BLAST
Repeati2272 – 229221YD 19Add
BLAST
Repeati2294 – 231421YD 20Add
BLAST
Repeati2326 – 234621YD 21Add
BLAST
Repeati2348 – 236821YD 22Add
BLAST
Repeati2394 – 243542YD 23Add
BLAST

Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated
Contains 8 EGF-like domains.PROSITE-ProRule annotation
Contains 6 NHL repeats.Curated
Contains 1 teneurin N-terminal domain.PROSITE-ProRule annotation
Contains 23 YD repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4659. Eukaryota.
ENOG410XQQD. LUCA.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ9W7R3.
PhylomeDBiQ9W7R3.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011041. Quinoprot_gluc/sorb_DH.
IPR022385. Rhs_assc_core.
IPR031325. RHS_repeat.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF9. PTHR11219:SF9. 3 hits.
PfamiPF05593. RHS_repeat. 1 hit.
PF06484. Ten_N. 1 hit.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF50952. SSF50952. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 3 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 4 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W7R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKERRPYR SLTSRRDTER RYTSSSADSE DGKINPKSYS SSETLKAFDQ
60 70 80 90 100
DSRLAYGSRV KDLVHHEADE FSRQGPDFSL RDMAFGDPVP PHMGAYRTEM
110 120 130 140 150
GLPHRDYSVS VASDADTETD GIMSPEHAVR LWGRSNTKSG RSSCLFSRAN
160 170 180 190 200
SNLTLTDTEH ENTENGPPLH CSSASSSPVD SPYPPPSHAA NQSQGRLLGN
210 220 230 240 250
SGAQAGRDSE SEDEFGPNSF LVKTGSGNVC TPAAATANEG SFQNHSRLRT
260 270 280 290 300
PPLPLFHSHS PSQHHTASIG SLSRSNYTQR SNPSPAPTDS SAPNEGPTSA
310 320 330 340 350
QDSSSAQDNW LLNSNVPLET RNIAKQTFLE TLQDNFIEMD ILATARRDGA
360 370 380 390 400
YTDGHFLFKP GGTSPLYCTT SPGYPLTSST VYSPPPRPLP RNTFSRPAFS
410 420 430 440 450
LKKPYKHCNW KCAALSAILI SVTLVFLLAY FIAMHLFGLN WHLQPVQRQI
460 470 480 490 500
YQLTEDNTSG LHLPTDLGLP PLGNTGLEFP DRGSRDDGKL DGFFPEDSFI
510 520 530 540 550
DMGEIDVGRK VAQLIPPGIF WRSQVFIDHP MYLKFNVSLS KDALVGIYGR
560 570 580 590 600
RGLPPSHTQF DFVELLDGRR LLSQGLPGLD GPPFPAQQRS LVPITSHDTG
610 620 630 640 650
CIQYMDSGIW HLAVYNDGKE TEQVSFLTTA IDSIDDCPSN CFGNGDCVSG
660 670 680 690 700
NCHCFPGFRG PDCSRASCPV LCSGNGQYLK GRCMCHSGWK GSECDVPTNQ
710 720 730 740 750
CIDITCSGHG TCIVGTCICN PSYKGENCEE VDCLDPTCSG RGVCVRGECH
760 770 780 790 800
CFVGWGGPGC ESPRASCMEQ CSGHGSFLAD TNTCNCDHNW TGHDCSTELC
810 820 830 840 850
AADCGGHGIC VAGSCRCDEG WMGTGCEQRA CHPRCSEHGT CKDGKCECSP
860 870 880 890 900
GWNGEHCTIE GCPGLCNGNG RCTLGNNGWY CVCQLGWRGA GCDTSMETAC
910 920 930 940 950
SDGKDNDGDG LTDCMDPDCC LQASCHTTSL CVGSPDPLDI IQETQISSSL
960 970 980 990 1000
STLQSFYQRI HFLVGRDSTH VIPDVNPFDG IHACVIRGQV VTSDGTPLVG
1010 1020 1030 1040 1050
VNISFINKPA YGYTITRQDG SFDLVSNGGV AIGLRFERAP FITQEHTLWL
1060 1070 1080 1090 1100
PWGRFFVMDT IVMRHEVNDI PSCDLSSFTR PMPIVLPAPL TAFAGTCPER
1110 1120 1130 1140 1150
GIVVPEIQTL QEEVRIPGTD MRLGYLSSRT SGYKSLLRIT LTHSTIPFSL
1160 1170 1180 1190 1200
MKVHLMVAVE GRLFRKWFSA APNLSYDFVW DKTDVYSQKV YGLSEAFVSV
1210 1220 1230 1240 1250
GFEYESCPDL ILWEKRTAVL QGYETTASNL GGWSVDKHHA LNIQSGILHK
1260 1270 1280 1290 1300
GNGENIFISQ QPPVIGSIMG NGRRRSISCP SCNGLADGNK LLAPVALACG
1310 1320 1330 1340 1350
SDGSLYVGDF NYVRRIFTTG NVTSVLELSN SPAHKYYLAT SPVSGWLYLS
1360 1370 1380 1390 1400
DTSSRKVFKV KSLYAVKDVA KNLELVAGTG DQCLPYDETR CGDGGKAVEA
1410 1420 1430 1440 1450
TLTNPRGITV DKYGVIFFVD GTMIRRIDQN GIISTLLGFN DLTSARPLSC
1460 1470 1480 1490 1500
DSVMDISQVR LEWPTDLAVS PMDNSLYVLD NNVVLQISEN HQVRIVAGRP
1510 1520 1530 1540 1550
MHCQVPGLDH FLVSKIAIHA TLESANALAV SHNGLLYIAE SDEKKINRVR
1560 1570 1580 1590 1600
QVSTNGEISL LAGAPSGCDC KNDANCDCYS GDDGYAKDAK LNAPSSLAVS
1610 1620 1630 1640 1650
PDGELFIADL GNIRIRYVRR NKAFLNPLNM YEISSPIDDE LYLFDVNASH
1660 1670 1680 1690 1700
VFTQSLTTGD YLYNFTYSGE GDLSSITDKN KNRVSIRRDS TGLPLWLMGP
1710 1720 1730 1740 1750
DGQTFWFTMG TNNALKSVAA QGQEIAVMTY HGSSGLLATK SNEDGWSTFY
1760 1770 1780 1790 1800
EYDNYGRLTN VTYPTGRVSS YRTDSDSTVR VQTEGSNKED ITVTTNLSAS
1810 1820 1830 1840 1850
GTFYTLMQDQ VKNSYYIGLD GSLRLVLANG MEVSLHTEPH LLSGTVNPTI
1860 1870 1880 1890 1900
SKRNVTLPID NGLNLVEWRQ RKEQARGQVT VYGRRLRVHN RNLLSMDFDR
1910 1920 1930 1940 1950
VTRTEKVYDD HRKFTLRIHY DHAGRPTLWA PSSRLNGVNV TYSPGGHIAG
1960 1970 1980 1990 2000
IQRGTMSVRM EYDQNGRITS KIFADGKSWS YTYLEKSMVL LLYSQRQYIF
2010 2020 2030 2040 2050
EFDKNDRLSS VTMPNVARQT LETTRSIGYY RNTYRPPEGN ATVLQDYSED
2060 2070 2080 2090 2100
GLLLQTIHQG TGRRVIYKYG KLSRLLEILY DTTRIAFSYD ESAGMLKTVG
2110 2120 2130 2140 2150
LQSEGFACTI RYRQIGPLID RQIFRFSEEG MVNARFDYNY DNSFRVTSMQ
2160 2170 2180 2190 2200
AVINETPLPI DLYRYDDVSG KTEQFGKFGV IYYDINQIIT TAVMTHTKHF
2210 2220 2230 2240 2250
DAYGRVKEVQ YEIFRSLMYW MMVQFDNMGR VVAKELKVGP YANTTRYAYE
2260 2270 2280 2290 2300
YDADGQLQVV SINDKPLWRY SYDLNGNLHL LSPGNSARLT PLRYDIRDRI
2310 2320 2330 2340 2350
TRLGDVQYRL DEDGFLRQRG NDFFEYNSAG LLVKTYNKVN GWTIKYRYDG
2360 2370 2380 2390 2400
LGRRVSSRST QGHHLQFFYA DLSSPTRVTH MYNHSSSEIT SLYYDLQGHL
2410 2420 2430 2440 2450
FAMELSSGDE FYVACDNIGT PLAVFSGAGL MIKQILHTAF GEVYLDSNPS
2460 2470 2480 2490 2500
FQLVIGYQGG LYEPLTKLVH MGRRDYDVLA GRWTTPDHDI RKRLNSDNIV
2510 2520 2530 2540 2550
PFNLYMFKNN NPLSNSQETK CYMTDVNSWL VTFGFQLYNV IPGYRKPVTD
2560 2570 2580 2590 2600
AMEPSYELVH TQIKTQEWDS TKSVLGVQCE VQRQLKSFVR LERFGQIYSA
2610 2620 2630 2640 2650
SDSGCPPTPL HTLFATGTSL FGKGVKVAIR EGRVEADIIS LANEDGRRIA
2660 2670 2680 2690 2700
AVLDKASYLQ DLHFTIAGLD THYFVKSGLV EGDLSLLGMT VGQRTLETGV
2710 2720 2730 2740 2750
NVTVSQVNMV LGGRSRRITD IQMQYGTLSL NVRYGSSVDE EKVRVLELAR
2760 2770 2780 2790 2800
QRAVATAWAH ERHRLRQGEE GSRAWTDGER QQLLSSGRVQ GYEGFYIVSV
2810 2820
DQFPELTDNI NNVHFWRQTE MGRR
Length:2,824
Mass (Da):313,506
Last modified:November 1, 1999 - v1
Checksum:i27007746DD34E356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026980 mRNA. Translation: BAA81893.1.
UniGeneiDr.81257.

Genome annotation databases

KEGGidre:30156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026980 mRNA. Translation: BAA81893.1.
UniGeneiDr.81257.

3D structure databases

ProteinModelPortaliQ9W7R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016395.

Proteomic databases

PaxDbiQ9W7R3.
PRIDEiQ9W7R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGidre:30156.

Organism-specific databases

CTDi26011.
ZFINiZDB-GENE-990714-20. tenm4.

Phylogenomic databases

eggNOGiKOG4659. Eukaryota.
ENOG410XQQD. LUCA.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ9W7R3.
PhylomeDBiQ9W7R3.

Miscellaneous databases

PROiQ9W7R3.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011041. Quinoprot_gluc/sorb_DH.
IPR022385. Rhs_assc_core.
IPR031325. RHS_repeat.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF9. PTHR11219:SF9. 3 hits.
PfamiPF05593. RHS_repeat. 1 hit.
PF06484. Ten_N. 1 hit.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF50952. SSF50952. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 3 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 4 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Compartmentalized expression of zebrafish ten-m3 and ten-m4, homologues of the Drosophila tenm /odd Oz gene, in the central nervous system."
    Mieda M., Kikuchi Y., Hirate Y., Aoki M., Okamoto H.
    Mech. Dev. 87:223-227(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryo.

Entry informationi

Entry nameiTEN4_DANRE
AccessioniPrimary (citable) accession number: Q9W7R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.