UniProtKB - Q9W7L2 (ENOA_SCEUN)
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Protein
Alpha-enolase
Gene
N/A
Organism
Sceloporus undulatus (Eastern fence lizard) (Stellio undulatus)
Status
Functioni
Catalytic activityi
2-phospho-D-glycerate = phosphoenolpyruvate + H2O.
Cofactori
Mg2+By similarityNote: Binds two Mg2+ per subunit. Required for catalysis and for stabilizing the dimer.By similarity
: glycolysis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.Proteins known to be involved in the 5 steps of the subpathway in this organism are:
- no protein annotated in this organism
- no protein annotated in this organism
- no protein annotated in this organism
- Alpha-enolase
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 40 | Magnesium 1By similarity | 1 | |
Binding sitei | 158 | SubstrateBy similarity | 1 | |
Binding sitei | 167 | SubstrateBy similarity | 1 | |
Active sitei | 210 | Proton donorBy similarity | 1 | |
Metal bindingi | 245 | Magnesium 2By similarity | 1 | |
Metal bindingi | 293 | Magnesium 2By similarity | 1 | |
Binding sitei | 293 | SubstrateBy similarity | 1 | |
Metal bindingi | 318 | Magnesium 2By similarity | 1 | |
Binding sitei | 318 | SubstrateBy similarity | 1 | |
Active sitei | 343 | Proton acceptorBy similarity | 1 | |
Binding sitei | 394 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: InterPro
- phosphopyruvate hydratase activity Source: UniProtKB-EC
GO - Biological processi
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase |
Biological process | Glycolysis |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00109; UER00187 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-enolase (EC:4.2.1.11)Alternative name(s): 2-phospho-D-glycerate hydro-lyase Phosphopyruvate hydratase |
Organismi | Sceloporus undulatus (Eastern fence lizard) (Stellio undulatus) |
Taxonomic identifieri | 8520 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Phrynosomatidae › Phrynosomatinae › Sceloporus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000134104 | 2 – 434 | Alpha-enolaseAdd BLAST | 433 |
Proteomic databases
PRIDEi | Q9W7L2 |
Interactioni
Subunit structurei
Homodimer.By similarity
Structurei
3D structure databases
ProteinModelPortali | Q9W7L2 |
SMRi | Q9W7L2 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 370 – 373 | Substrate bindingBy similarity | 4 |
Sequence similaritiesi
Belongs to the enolase family.Curated
Phylogenomic databases
HOVERGENi | HBG000067 |
Family and domain databases
CDDi | cd03313 enolase, 1 hit |
Gene3Di | 3.20.20.1201 hit 3.30.390.101 hit |
HAMAPi | MF_00318 Enolase, 1 hit |
InterProi | View protein in InterPro IPR000941 Enolase IPR036849 Enolase-like_C_sf IPR029017 Enolase-like_N IPR034390 Enolase-like_superfamily IPR020810 Enolase_C IPR020809 Enolase_CS IPR020811 Enolase_N |
PANTHERi | PTHR11902 PTHR11902, 1 hit |
Pfami | View protein in Pfam PF00113 Enolase_C, 1 hit PF03952 Enolase_N, 1 hit |
PIRSFi | PIRSF001400 Enolase, 1 hit |
PRINTSi | PR00148 ENOLASE |
SFLDi | SFLDG00178 enolase, 1 hit SFLDS00001 Enolase, 1 hit |
SMARTi | View protein in SMART SM01192 Enolase_C, 1 hit SM01193 Enolase_N, 1 hit |
SUPFAMi | SSF51604 SSF51604, 1 hit |
TIGRFAMsi | TIGR01060 eno, 1 hit |
PROSITEi | View protein in PROSITE PS00164 ENOLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9W7L2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSILKLHARE IFDSRGNPTV EVDLYTNKGL FRAAVPSGAS TGIYEALELR
60 70 80 90 100
DNDKTRFLGK GVSKAVEHVN KTIAPALVNK KVNVVEQEKI DKLMLEMDGT
110 120 130 140 150
ENKSKFGANA ILGVSLAVCK AGAAEKGVPL YRHIADLAGN EDVILPVPAF
160 170 180 190 200
NVINGGSHAG NKLAMQEFMI LPVGAENFKE AMRIGAEVYQ NLKNVIKEKY
210 220 230 240 250
GKDATNVGDE GGFAPNILEN KEALELLKSA ISKAGYTDKI VIGMDVAASE
260 270 280 290 300
FYRDGKYDLD FKSPDDPSRY ITPDQLSDLY KGFIKNYPVV SIEDPFDQHD
310 320 330 340 350
WAAWKKFTAS AGIQVVGDDL TVTNPRRITK AVEEKSCNCL LLKVNQIGSV
360 370 380 390 400
TESLQACKLA QTNGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR
410 420 430
SERLAKYNQI LRIEEELGSK GRFAGRNFRN PRVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF072587 mRNA Translation: AAD41644.1 |
Similar proteinsi
Entry informationi
Entry namei | ENOA_SCEUN | |
Accessioni | Q9W7L2Primary (citable) accession number: Q9W7L2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 28, 2018 | |
This is version 82 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |