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Protein

Spondin-1

Gene

SPON1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Somite-derived spondin 1 is an inhibitory signal involved in patterning the segmental migration of neural crest cells and their topographical segregation within the rostral somites in vitro. May be required to prevent the lateral drifting of the commissural axons after having crossed the floor plate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi320CalciumBy similarity1
Metal bindingi349CalciumBy similarity1
Metal bindingi353Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spondin-1
Alternative name(s):
F-spondin
Gene namesi
Name:SPON1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003586824 – 802Spondin-1Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 123PROSITE-ProRule annotation
Disulfide bondi151 ↔ 177PROSITE-ProRule annotation
Disulfide bondi194 ↔ 331By similarity
Disulfide bondi195 ↔ 335By similarity
Disulfide bondi197 ↔ 410By similarity
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi438 ↔ 475PROSITE-ProRule annotation
Disulfide bondi449 ↔ 484PROSITE-ProRule annotation
Disulfide bondi454 ↔ 489PROSITE-ProRule annotation
Disulfide bondi497 ↔ 533PROSITE-ProRule annotation
Disulfide bondi508 ↔ 512PROSITE-ProRule annotation
Disulfide bondi543 ↔ 549PROSITE-ProRule annotation
Disulfide bondi554 ↔ 590PROSITE-ProRule annotation
Disulfide bondi565 ↔ 569PROSITE-ProRule annotation
Disulfide bondi600 ↔ 605PROSITE-ProRule annotation
Disulfide bondi610 ↔ 645PROSITE-ProRule annotation
Disulfide bondi621 ↔ 625PROSITE-ProRule annotation
Disulfide bondi655 ↔ 660PROSITE-ProRule annotation
Glycosylationi676N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9W770.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039229.

Structurei

3D structure databases

ProteinModelPortaliQ9W770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 189ReelinPROSITE-ProRule annotationAdd BLAST166
Domaini190 – 383SpondinPROSITE-ProRule annotationAdd BLAST194
Domaini437 – 490TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini496 – 550TSP type-1 2PROSITE-ProRule annotationAdd BLAST55
Domaini553 – 606TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini609 – 661TSP type-1 4PROSITE-ProRule annotationAdd BLAST53
Domaini663 – 716TSP type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini749 – 801TSP type-1 6PROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 reelin domain.PROSITE-ProRule annotation
Contains 1 spondin domain.PROSITE-ProRule annotation
Contains 6 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3539. Eukaryota.
ENOG410XQHP. LUCA.
HOGENOMiHOG000124667.
HOVERGENiHBG052920.
InParanoidiQ9W770.
PhylomeDBiQ9W770.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR002861. Reeler_dom.
IPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF02014. Reeler. 1 hit.
PF06468. Spond_N. 1 hit.
PF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS51019. REELIN. 1 hit.
PS51020. SPONDIN. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARLRPLAL RLLARTFPLV ARGFSDETLE KAAKSEGYCS RILRAQGTRR
60 70 80 90 100
EGYNEFSLRV EGDPEFYKPG NSYRVTLSAA TPAYFRGFTL IALKEGKEGD
110 120 130 140 150
KEEDHAGTFQ IIDEEETQFM SNCPVAVTES TPRRRTRIQV FWTAPPTGTG
160 170 180 190 200
CVILKASIVQ KRIIYFQDEG SLTKRICEQD SASEGVTDKP TLDCCACGTA
210 220 230 240 250
KYRLTFYGNW SEKTHPKDFP RRTNHWSAII GSSHSKNYIL WEYGGYASEG
260 270 280 290 300
VKQVAELGSP VKMEEEIRQQ SDEVLTVIKA KAQWPAWQPL NVRAAPSAEF
310 320 330 340 350
SVDRHRHLMS FLTMLGPSPD WNVGLSAEDL CTKDCGWVQK VVQDLIPWDA
360 370 380 390 400
GTDSGVTYES PNKPTVPQEK IRPLTSLDHP QSPFYDPEGG SIKLVARVVL
410 420 430 440 450
ERIARKGEQC NFVPDNIDDI VADLAPEEKE EDDTPETCIY SNWSPWSACS
460 470 480 490 500
SSTCEKGKRM RQRMLKAQLD LSVPCPDTQD FQPCMGPGCS DEDGSTCMMS
510 520 530 540 550
DWITWSPCSV SCGMGTRSRE RYVKQFPEDG SMCKVPTEET EKCIVNEECS
560 570 580 590 600
PSSCLVTEWG EWDECSASCG TGMKRRHRMI KMTPADGSMC KAETTEAEKC
610 620 630 640 650
MMPECHTIPC LLSPWSEWSD CSVTCGKGMR TRQRMLKSAA ELGDCNEELE
660 670 680 690 700
QAEKCMLPEC PIDCELTEWS QWSECNTSCG KGHMIRTRMI KIEPQFGGTA
710 720 730 740 750
CPETVQRTKC RVRKCLRGPG MEKRRWKEAR EKRRSEQAKK NIDNEQYPVC
760 770 780 790 800
RLKPWTAWTE CSTLCGGGIQ ERYMMVKKRS KSTQFTSCKD KKELRACNVH

PC
Length:802
Mass (Da):90,510
Last modified:November 1, 1999 - v1
Checksum:i0644D2BDD0A0FE12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149302 mRNA. Translation: AAD41495.1.
RefSeqiNP_990182.1. NM_204851.1.
UniGeneiGga.3330.

Genome annotation databases

GeneIDi395657.
KEGGigga:395657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149302 mRNA. Translation: AAD41495.1.
RefSeqiNP_990182.1. NM_204851.1.
UniGeneiGga.3330.

3D structure databases

ProteinModelPortaliQ9W770.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039229.

Proteomic databases

PaxDbiQ9W770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395657.
KEGGigga:395657.

Organism-specific databases

CTDi10418.

Phylogenomic databases

eggNOGiKOG3539. Eukaryota.
ENOG410XQHP. LUCA.
HOGENOMiHOG000124667.
HOVERGENiHBG052920.
InParanoidiQ9W770.
PhylomeDBiQ9W770.

Miscellaneous databases

PROiQ9W770.

Family and domain databases

CDDicd08544. Reeler. 1 hit.
InterProiIPR002861. Reeler_dom.
IPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF02014. Reeler. 1 hit.
PF06468. Spond_N. 1 hit.
PF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS51019. REELIN. 1 hit.
PS51020. SPONDIN. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPON1_CHICK
AccessioniPrimary (citable) accession number: Q9W770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1999
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.