Reviewed, UniProtKB/Swiss-Prot Q9W758 (CTBP2_XENLA)

Names and origin

Protein names

Recommended name:
    C-terminal-binding protein 2
      Short name=CtBP2
Alternative name(s):
    C-terminal-binding protein B
    TCF-3 corepressor CtBP
    XCtBP

Gene names

Name:	ctbp2
Synonyms:	ctbp-B

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Corepressor targeting diverse transcription regulators. Ref.1
Subunit structure	Interacts with the C-terminus of tcf7l1-a via the consensus motifs P-X-[DNS]-L-[STVA]. Ref.1
Subcellular location	Nucleus By similarity.
Developmental stage	Expressed throughout development. Localized to discrete structures during neurulation. The pattern of expression is increasingly refined to include the head, central nervous system and tissues along the dorsal midline to the tailbud. Ref.1
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Wnt signaling pathway
Cellular component	Nucleus
Molecular function	Oxidoreductase Repressor
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	C-terminal-binding protein 2		PRO_0000076047
Sites
	Active site	269	1	Potential
	Active site	298	1	Potential
	Active site	318	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9W758-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 49D2FEFD82E2B010	FASTA	437	47,776
	10 20 30 40 50 60 MDKHKVKRQR LDRICDGIRP PILNGPMPVR PLVALLDGRD CTIEMPILKD VATVAFCDAQ 70 80 90 100 110 120 STQEIHEKVL SEAVGALMYH TITLSREDLE KFKALRIIIK IGSGYDNIDI KSAAELGIAV 130 140 150 160 170 180 CNIPSASVEE TADSTLCHIL NLYRRVTWLH QAMREGNRPA SVEQIREVAG GAARIRGETL 190 200 210 220 230 240 GIIGLGRIGQ AVALRAKAFN FTVIFYDPYL ADGVERSLGL QRMATLQELL MHSDCITLHC 250 260 270 280 290 300 NLNEHNHHLI NDFTIKQMRQ GCFLVNTARG GLVDEKALAQ ALKDGRIRGA ALDVHESEPF 310 320 330 340 350 360 SFSQGPLKDA PNLICTPHTA WYSEHASIEA REEAAKEIRR AIAGPIPDSL RNCVNKDYLL 370 380 390 400 410 420 AAVQWSGMEQ AAVHPELNGA SSYRFPPGVV GVTSAGHPSA IEGLVASSHP LIPSVSHTPS 430 PGQTTKPDPD REIPTDQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development." Brannon M., Brown J.D., Bates R., Kimelman D., Moon R.T. Development 126:3159-3170(1999) [PubMed: 10375506] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TCF7L1-A, DEVELOPMENTAL STAGE.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Oocyte.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF152006 mRNA. Translation: AAD41370.1. BC076800 mRNA. Translation: AAH76800.1.
RefSeq	NP_001081966.1.
UniGene	Xl.41670
3D structure databases
HSSP	HSSP built from PDB template 1HKU based on UniProtKB Q9Z2F5.
SMR	Q9W758. Positions 31-355.
ModBase	Search...
Proteomic databases
PRIDE	Q9W758.
Genome annotation databases
GeneID	398147.
KEGG	xla:398147.
Phylogenomic databases
HOVERGEN	Q9W758.
Family and domain databases
InterPro	IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. False negative. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTBP2_XENLA

Accession

Primary (citable) accession number: Q9W758
Secondary accession number(s): Q6DFD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project