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Protein

Mitochondrial uncoupling protein 2

Gene

ucp2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
Gene namesi
Name:ucp2
Synonyms:slc25a8
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990708-8. ucp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial matrixSequence analysis
Transmembranei11 – 3222Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini33 – 7846Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei79 – 10123Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 12019Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei121 – 13717Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 18144Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei182 – 19817Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini199 – 21517Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei216 – 23520Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini236 – 26934Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei270 – 29223Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini293 – 31018Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Mitochondrial uncoupling protein 2PRO_0000090668Add
BLAST

Proteomic databases

PaxDbiQ9W720.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063358.

Structurei

3D structure databases

ProteinModelPortaliQ9W720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10797Solcar 1Add
BLAST
Repeati115 – 20490Solcar 2Add
BLAST
Repeati213 – 29886Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni277 – 29923Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9W720.
PhylomeDBiQ9W720.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFRAGDVP PTATVKFIGA GTAACIADLF TFPLDTAKVR LQIQGENKAS
60 70 80 90 100
TNMGRGPVKY RGVFGTISTM VRVEGPRSLY SGLVAGLQRQ MSFASVRIGL
110 120 130 140 150
YDSVKQFYTK GSDHAGIGSR LMAGCTTGAM AVAVAQPTDV LKVRFQAQVS
160 170 180 190 200
AGASKRYHST MDAYRTIAKE EGFRGLWKGT GPNITRNAIV NCTELVTYDL
210 220 230 240 250
IKDALLKSSL MTDDLPCHFT SAFGAGFCTT IIASPVDVVK TRYMNSAQGQ
260 270 280 290 300
YSSALNCAVA MLTKKGPKAF FKGFMPSFLR LGSWNVVMFV TYEQLKRAMM
310
AARQNWHTPL
Length:310
Mass (Da):33,573
Last modified:November 1, 1999 - v1
Checksum:i1A2FF82FA2CB1DD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243250 mRNA. Translation: CAB46268.1.
UniGeneiDr.21244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243250 mRNA. Translation: CAB46268.1.
UniGeneiDr.21244.

3D structure databases

ProteinModelPortaliQ9W720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063358.

Proteomic databases

PaxDbiQ9W720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990708-8. ucp2.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9W720.
PhylomeDBiQ9W720.

Miscellaneous databases

PROiQ9W720.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Uncoupling protein 1 homologues and thermogenesis? UCPs from cold-blooded vertebrates."
    Stuart J.A., Harper J.A., Brindle K.M., Brand M.D.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUCP2_DANRE
AccessioniPrimary (citable) accession number: Q9W720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.