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Q9W705

- NCOA2_XENLA

UniProt

Q9W705 - NCOA2_XENLA

Protein

Nuclear receptor coactivator 2

Gene

ncoa2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) By similarity. Required in a nuclear receptor pathway to suppress expression of dorsal mesoderm genes.By similarity1 Publication

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: InterPro
    2. signal transducer activity Source: InterPro
    3. thyroid hormone receptor binding Source: UniProtKB
    4. thyroid hormone receptor coactivator activity Source: UniProtKB

    GO - Biological processi

    1. embryo development Source: UniProtKB
    2. intracellular signal transduction Source: UniProtKB
    3. positive regulation of receptor activity Source: GOC
    4. regulation of transcription, DNA-templated Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor coactivator 2
    Short name:
    NCoA-2
    Alternative name(s):
    Transcriptional intermediary factor 2
    Short name:
    xTIF2
    Gene namesi
    Name:ncoa2
    Synonyms:tif2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-864856. ncoa2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15161516Nuclear receptor coactivator 2PRO_0000094405Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed homogeneously during late blastula-early gastrula stages, becoming highly expressed in the notochord in the late gastrula and neurula stages. At hatching, restricted to a few areas including the blood precursor region, prospective pronephros and retina.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9W705.
    SMRiQ9W705. Positions 1056-1100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 8058bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini116 – 18065PASPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi628 – 6325LXXLL motif 1
    Motifi680 – 6845LXXLL motif 2
    Motifi735 – 7395LXXLL motif 3
    Motifi1064 – 10729LLXXLXXXL motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1237 – 127337Poly-GlnAdd
    BLAST

    Domaini

    Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and, at least in part, functionally redundant (By similarity).By similarity
    The LLXXLXXXL motif is involved in transcriptional coactivation and crebbp/cbp binding.By similarity

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG052583.
    KOiK11255.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    4.10.630.10. 2 hits.
    InterProiIPR011598. bHLH_dom.
    IPR010011. DUF1518.
    IPR028822. NCOA2.
    IPR009110. Nuc_rcpt_coact.
    IPR014920. Nuc_rcpt_coact_Ncoa-typ.
    IPR017426. Nuclear_rcpt_coactivator.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR014935. SRC-1.
    IPR008955. Src1_rcpt_coact.
    [Graphical view]
    PANTHERiPTHR10684. PTHR10684. 1 hit.
    PTHR10684:SF2. PTHR10684:SF2. 1 hit.
    PfamiPF07469. DUF1518. 2 hits.
    PF08815. Nuc_rec_co-act. 1 hit.
    PF00989. PAS. 1 hit.
    PF08832. SRC-1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
    SMARTiSM00353. HLH. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9W705-1 [UniParc]FASTAAdd to Basket

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    MGENLSDPSR AEPRKRKESL DQLGPSPKRS TEKRNREQEN KYIEELAELI     50
    FANFNDIDNL NFKPDKCAIL KETVKQIRQI KEHEKTAAAN EDEVQKADVS 100
    STGQSVIDKD ALGPMMLEAL DGFFFVVNRE GNVVFVSENV TQYLRYNQEE 150
    LMNTSVYSIL HVGDHSEFIK NLLPKSLVNG VPRRNSHTFN CRMLVKPMME 200
    CEEERHDGQE THQKYESMQC FAVSQPKSIK EEGEDFQSCL ICVARRVPVK 250
    ERPVPPPSES FTTRQDFQGK ITSLDTTSMR ALMRPGWEDM VRRCIQRFHS 300
    QHDGEISYSR RHHQEVLRQG HATSPFYRFS LSDGTTVVAQ TKSRLMRSQT 350
    NNEPPLVLSL HVLQREQNVC GLNQDLAGQA MGKTLNPVQS SSPAHQAMYG 400
    GNPGQDTTIS SNMNYAISGP KEQMGLATGR FVGSGGMNHI SSLQATTPQG 450
    NNYALKMNSP SHGSPGMGQG QPNSMLSPRH RVSPGVAGSP RIAPSPFSPA 500
    GSLHSPVSVC SSTGNSHSYT NSSLNALQAL SEGQGPLAPP LSSPDLKGGN 550
    LQHSPGNMNP PQLRKMGSID SKESFGLYEE QPESATGQGE SGCHSNEQKD 600
    CGENLSSVVD KTEGQSRLLD GKGQQKLLKL LTTKSDQMEP STLPSNTLGD 650
    MNKDSLSNFA SNSMSASAHG TSLKEKHKIL HRLLQDSSSP VDLAKLTAEA 700
    TGKELSQESN STGPGSEVTI KQEPVSPKKK EHALLRYLLD KDDTTDNVAD 750
    ITPKLERADN KVDPSSCPKL SAVKAEKEEP NFGHTDQPGS DFDNLDEILD 800
    DLQNSQLSQL FSDTRHDGNS ADKQAIMNDL MQLAGENSTG LPAWAQKQRM 850
    LRMQQNNGFN SQLAAQLGRL PNQNLPLDIH FQSQASAGSF AQMRSSGPYT 900
    TVPQSGVINN QAMMGSQGNV RNSSPGIVGV NGPRPPLKPG DWGSQASAVR 950
    PACPTTSTAM NRHDMSRSPT ASIPMRPGSQ VCPRQVLQSA VMNMGSSELD 1000
    MNISGPQYTQ QQAPPNQTAP WPNRILTIEQ PSFNNQNRQP FGSPADDLIC 1050
    QPIVSESPAD DGNLLDQLYM ALRNFDGLEE IDRALGIPEM VSQGQAVEQE 1100
    SFGSPESNLM MEQKPPVYNH AYANQGQMAQ NSYQPMQDPG FNPMGQRPSY 1150
    GILRMQNRPG LRPTGMVQNQ PNQLRLQLQH RLQAQNRQQL MNPINNVSNM 1200
    NLAMRPGVPG QLREQGPINA QMLAQRQREI LSQHLRQKQL QQQQQQQQQQ 1250
    QQQQQQQQQQ QQQQQQQQQQ QQQHRAMMMR SQGLAMPPNM VGSGGIPASI 1300
    NSPRIPQGST QQFPFPPNYG TGIPSPPPFT SPFSPVPPSP GSQSLSHSSL 1350
    HGSQMNLANQ GIMGSMGGQY GPVMNPQMQH NAFQFANSGM SQQSDPGFTG 1400
    ATTPQSPIMS PRMGHIQSSM MQQSQANPAY QSELNGWAQG NPAGNSMFSQ 1450
    QSPPHFGQQS GTSMYNSNNM NISVSMAANG NGMNNMNQMT GQINMTSVTS 1500
    VPTSGLSSMG PEQKYC 1516
    Length:1,516
    Mass (Da):166,156
    Last modified:November 1, 1999 - v1
    Checksum:i09851C00AB439A4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243119 mRNA. Translation: CAB45389.1.
    RefSeqiNP_001081139.1. NM_001087670.1.
    UniGeneiXl.4857.

    Genome annotation databases

    GeneIDi394405.
    KEGGixla:394405.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243119 mRNA. Translation: CAB45389.1 .
    RefSeqi NP_001081139.1. NM_001087670.1.
    UniGenei Xl.4857.

    3D structure databases

    ProteinModelPortali Q9W705.
    SMRi Q9W705. Positions 1056-1100.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 394405.
    KEGGi xla:394405.

    Organism-specific databases

    CTDi 10499.
    Xenbasei XB-GENE-864856. ncoa2.

    Phylogenomic databases

    HOVERGENi HBG052583.
    KOi K11255.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    4.10.630.10. 2 hits.
    InterProi IPR011598. bHLH_dom.
    IPR010011. DUF1518.
    IPR028822. NCOA2.
    IPR009110. Nuc_rcpt_coact.
    IPR014920. Nuc_rcpt_coact_Ncoa-typ.
    IPR017426. Nuclear_rcpt_coactivator.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR014935. SRC-1.
    IPR008955. Src1_rcpt_coact.
    [Graphical view ]
    PANTHERi PTHR10684. PTHR10684. 1 hit.
    PTHR10684:SF2. PTHR10684:SF2. 1 hit.
    Pfami PF07469. DUF1518. 2 hits.
    PF08815. Nuc_rec_co-act. 1 hit.
    PF00989. PAS. 1 hit.
    PF08832. SRC-1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038181. Nuclear_receptor_coactivator. 1 hit.
    SMARTi SM00353. HLH. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    SSF69125. SSF69125. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "XTIF2, a Xenopus homologue of the human transcription intermediary factor, is required for a nuclear receptor pathway that also interacts with CBP to suppress Brachyury and XMyoD."
      de la Calle-Mustienes E., Gomez-Skarmeta J.L.
      Mech. Dev. 91:119-129(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNCOA2_XENLA
    AccessioniPrimary (citable) accession number: Q9W705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3