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Q9W6V5

- PTPRJ_CHICK

UniProt

Q9W6V5 - PTPRJ_CHICK

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Protein

Receptor-type tyrosine-protein phosphatase eta

Gene

PTPRJ

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates. Plays a role in cell adhesion, migration, proliferation and differentiation (By similarity). May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells.By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1274 – 12741SubstrateBy similarity
Active sitei1308 – 13081Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1352 – 13521SubstrateBy similarity

GO - Molecular functioni

  1. phosphatase activity Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  2. negative regulation of MAP kinase activity Source: UniProtKB
  3. negative regulation of protein kinase B signaling Source: UniProtKB
  4. negative regulation of T cell receptor signaling pathway Source: UniProtKB
  5. platelet-derived growth factor receptor signaling pathway Source: UniProtKB
  6. positive regulation of cell adhesion Source: UniProtKB
  7. positive regulation of focal adhesion assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase eta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase eta
Short name:
R-PTP-eta
Alternative name(s):
HPTP eta
Protein-tyrosine phosphatase receptor type J
Short name:
R-PTP-J
Supporting-cell antigen
Gene namesi
Name:PTPRJ
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionruffle membrane By similarity. Cell junction By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 10441020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1045 – 106521HelicalSequence AnalysisAdd
BLAST
Topological domaini1066 – 1406341CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: UniProtKB
  2. cell projection Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 14061382Receptor-type tyrosine-protein phosphatase etaPRO_5000065173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi745 – 7451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi750 – 7501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi766 – 7661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi828 – 8281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1010 – 10101N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Found on the apical surfaces of retinal Mueller cells, renal tubule cells and intestinal brush border cells.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9W6V5.
SMRiQ9W6V5. Positions 1088-1380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17089Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini171 – 25989Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini260 – 34384Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini346 – 43792Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini438 – 52386Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini524 – 61491Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini615 – 70389Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini704 – 79390Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini794 – 88895Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini887 – 97993Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1110 – 1367258Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1308 – 13147Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1066 – 10694Poly-Arg

Sequence similaritiesi

Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053761.
InParanoidiQ9W6V5.
KOiK05698.
PhylomeDBiQ9W6V5.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 8 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W6V5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRRLPLLPPC PLLLLLLLPA EVRCTTACTD DCSLKNVTEE MGTSSNDELS
60 70 80 90 100
VNATSGNRRL SEDVSLPGRA MSDQNSVAQP RAVLDLKTEY VGVTSVNLTW
110 120 130 140 150
TVNDTASDSY TYRIEVRNGS SINNKTSDIT DAEITGLIPG TLYTFTVFAV
160 170 180 190 200
AADGQTAGEG ASISLYTKPS PVLDLKAEYV GVTSVNLTWT VNDTASASYT
210 220 230 240 250
YRIEVTSDSS IDSLTSSVTM AEITGLIPGT LYSFKVFAVA ADNRTEADGA
260 270 280 290 300
SISLYTKPSP VLDLKAEYVG VTSVNLTWTV NGTALTAYTY RIEVRNATSI
310 320 330 340 350
RNETSNINKI EITGLIPGTS YNFKVFATPV NNTTEEEGLS LNLYTKPSPV
360 370 380 390 400
LRVVTEYVGV TSVNLTWMVD DTASDSYTYR IEVRNGSSIN NKTSDITDAE
410 420 430 440 450
ITGLIPGTLY TFTVFAVAAD GQTAGEGASI SLYTKPSPVL DLKAEYVGVT
460 470 480 490 500
SVNLTWTVND TASASYTYRI EVTSDSSIDS LTSNVTMAEI TGLIPGTLYN
510 520 530 540 550
FTVFAVAADN RTEADGAFTS LYTKPTPVTD LKAEHGVTSV SLNWMVNDTA
560 570 580 590 600
SDSYTYRIEV RNGHSVNNKT SNIPETEITG LNPGTLYTFT VFAVAADGET
610 620 630 640 650
EGEGASISVY TKPRAVLHLK TEYVGVTSVN LTWTVNDTDS ASYTYRIEVR
660 670 680 690 700
NGSSINNKTS DITDAEITGL DPGTLYIFTV FAVAADGQTA GEGASISLYT
710 720 730 740 750
KPSMVLNLKA EYVTMTSVNL TWMVNDAESA SYTYRIEVAH ESLINETMSN
760 770 780 790 800
VTKSIVTYLI PGTSYNFTVF AIAADNQTEG EGASISQNTV PSSVNAFQCE
810 820 830 840 850
AVANMSYLTL KWNCPYGGYS GFDIEIFNGT WTKKQQSQFC GREGSEEIFK
860 870 880 890 900
TEPLDYYKTY TVSVTTVSDG LTSLPVQKIC KTSITDPPVP NKAPLVKAVS
910 920 930 940 950
HNSLSVEFPD FESVNGPLKA YAVMIVTEAE GCLPSKSDLD YTYNDFKQKM
960 970 980 990 1000
TATYVTYVID VEEISSSSHS QNGHNIVDVG KGNTMYGYEN GPLIPLHSYR
1010 1020 1030 1040 1050
ASVAGFTNIN FTVANKIMGE QSYVSFSPCS EVVSLPQDPG VIAGAVIGCL
1060 1070 1080 1090 1100
LAILAVVAIG GYIFWRRRRK DKRNTEVSFS PIKIKKSKMI KVENFESYFK
1110 1120 1130 1140 1150
KQQADSNCGF AEEYEELKSA GVHQPKFAAE IAENRGKNRY NNVLPYDISR
1160 1170 1180 1190 1200
VKLSNPSCTT DDYINANYMP GYSSKKAFIA AQGPLPNTIE DFWRMIWEKN
1210 1220 1230 1240 1250
IYSIVMLTKC VEQARTKCEQ YWPDKQSKSY GDIIVTMVSE VVLPEWTIRD
1260 1270 1280 1290 1300
FNVENADTME SHTVRQFHFT SWPDHGVPET TDLLINFRHL VHEYSSQNPI
1310 1320 1330 1340 1350
DSPILVHCSA GVGRTGTFIA IDRLIQQIEM ENTVDVYGVV YDLRMHRPLM
1360 1370 1380 1390 1400
VQTEDQYVFL NQCVMDIIRS QKEKKTDLIY QNTTAMAIYE NFTPGPAFGK

ANGYHA
Length:1,406
Mass (Da):154,214
Last modified:October 1, 2001 - v2
Checksum:i2D609885CC0F367B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238216 mRNA. Translation: CAB41885.2.
RefSeqiNP_989952.1. NM_204621.1.
UniGeneiGga.966.

Genome annotation databases

GeneIDi395330.
KEGGigga:395330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238216 mRNA. Translation: CAB41885.2 .
RefSeqi NP_989952.1. NM_204621.1.
UniGenei Gga.966.

3D structure databases

ProteinModelPortali Q9W6V5.
SMRi Q9W6V5. Positions 1088-1380.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395330.
KEGGi gga:395330.

Organism-specific databases

CTDi 5795.

Phylogenomic databases

HOVERGENi HBG053761.
InParanoidi Q9W6V5.
KOi K05698.
PhylomeDBi Q9W6V5.

Miscellaneous databases

NextBioi 20815415.
PROi Q9W6V5.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 8 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear."
    Kruger R.P., Goodyear R.J., Legan P.K., Warchol M.E., Raphael Y., Cotanche D.A., Richardson G.P.
    J. Neurosci. 19:4815-4827(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Intestine.

Entry informationi

Entry nameiPTPRJ_CHICK
AccessioniPrimary (citable) accession number: Q9W6V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3