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Q9W6V5 (PTPRJ_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase eta
Short name=Protein-tyrosine phosphatase eta
Short name=R-PTP-eta
EC=3.1.3.48
Alternative name(s):
HPTP eta
Protein-tyrosine phosphatase receptor type J
Short name=R-PTP-J
Supporting-cell antigen
Gene names
Name:PTPRJ
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length1406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates. Plays a role in cell adhesion, migration, proliferation and differentiation By similarity. May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells. Ref.1

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell projection › ruffle membrane By similarity. Cell junction By similarity.

Tissue specificity

Found on the apical surfaces of retinal Mueller cells, renal tubule cells and intestinal brush border cells. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

Contains 10 fibronectin type-III domains.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Cell projection
Membrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Protein phosphatase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of MAP kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of T cell receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of epidermal growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein kinase B signaling cascade

Inferred from sequence or structural similarity. Source: UniProtKB

peptidyl-tyrosine dephosphorylation

Inferred from electronic annotation. Source: GOC

platelet-derived growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of focal adhesion assembly

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcell-cell junction

Inferred from sequence or structural similarity. Source: UniProtKB

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

ruffle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 14061382Receptor-type tyrosine-protein phosphatase eta
PRO_5000065173

Regions

Topological domain25 – 10441020Extracellular Potential
Transmembrane1045 – 106521Helical; Potential
Topological domain1066 – 1406341Cytoplasmic Potential
Domain80 – 16788Fibronectin type-III 1
Domain169 – 25688Fibronectin type-III 2
Domain258 – 34588Fibronectin type-III 3
Domain347 – 43488Fibronectin type-III 4
Domain436 – 52388Fibronectin type-III 5
Domain525 – 61187Fibronectin type-III 6
Domain613 – 70088Fibronectin type-III 7
Domain702 – 78988Fibronectin type-III 8
Domain791 – 88292Fibronectin type-III 9
Domain887 – 97993Fibronectin type-III 10
Domain1110 – 1367258Tyrosine-protein phosphatase
Region1308 – 13147Substrate binding By similarity
Compositional bias1066 – 10694Poly-Arg

Sites

Active site13081Phosphocysteine intermediate By similarity
Binding site12741Substrate By similarity
Binding site13521Substrate By similarity

Amino acid modifications

Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation2751N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Glycosylation3321N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation3851N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4531N-linked (GlcNAc...) Potential
Glycosylation4591N-linked (GlcNAc...) Potential
Glycosylation4841N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential
Glycosylation5101N-linked (GlcNAc...) Potential
Glycosylation5471N-linked (GlcNAc...) Potential
Glycosylation5681N-linked (GlcNAc...) Potential
Glycosylation6301N-linked (GlcNAc...) Potential
Glycosylation6361N-linked (GlcNAc...) Potential
Glycosylation6511N-linked (GlcNAc...) Potential
Glycosylation6571N-linked (GlcNAc...) Potential
Glycosylation7191N-linked (GlcNAc...) Potential
Glycosylation7451N-linked (GlcNAc...) Potential
Glycosylation7501N-linked (GlcNAc...) Potential
Glycosylation7661N-linked (GlcNAc...) Potential
Glycosylation7761N-linked (GlcNAc...) Potential
Glycosylation8041N-linked (GlcNAc...) Potential
Glycosylation8281N-linked (GlcNAc...) Potential
Glycosylation10101N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9W6V5 [UniParc].

Last modified October 1, 2001. Version 2.
Checksum: 2D609885CC0F367B

FASTA1,406154,214
        10         20         30         40         50         60 
MRRLPLLPPC PLLLLLLLPA EVRCTTACTD DCSLKNVTEE MGTSSNDELS VNATSGNRRL 

        70         80         90        100        110        120 
SEDVSLPGRA MSDQNSVAQP RAVLDLKTEY VGVTSVNLTW TVNDTASDSY TYRIEVRNGS 

       130        140        150        160        170        180 
SINNKTSDIT DAEITGLIPG TLYTFTVFAV AADGQTAGEG ASISLYTKPS PVLDLKAEYV 

       190        200        210        220        230        240 
GVTSVNLTWT VNDTASASYT YRIEVTSDSS IDSLTSSVTM AEITGLIPGT LYSFKVFAVA 

       250        260        270        280        290        300 
ADNRTEADGA SISLYTKPSP VLDLKAEYVG VTSVNLTWTV NGTALTAYTY RIEVRNATSI 

       310        320        330        340        350        360 
RNETSNINKI EITGLIPGTS YNFKVFATPV NNTTEEEGLS LNLYTKPSPV LRVVTEYVGV 

       370        380        390        400        410        420 
TSVNLTWMVD DTASDSYTYR IEVRNGSSIN NKTSDITDAE ITGLIPGTLY TFTVFAVAAD 

       430        440        450        460        470        480 
GQTAGEGASI SLYTKPSPVL DLKAEYVGVT SVNLTWTVND TASASYTYRI EVTSDSSIDS 

       490        500        510        520        530        540 
LTSNVTMAEI TGLIPGTLYN FTVFAVAADN RTEADGAFTS LYTKPTPVTD LKAEHGVTSV 

       550        560        570        580        590        600 
SLNWMVNDTA SDSYTYRIEV RNGHSVNNKT SNIPETEITG LNPGTLYTFT VFAVAADGET 

       610        620        630        640        650        660 
EGEGASISVY TKPRAVLHLK TEYVGVTSVN LTWTVNDTDS ASYTYRIEVR NGSSINNKTS 

       670        680        690        700        710        720 
DITDAEITGL DPGTLYIFTV FAVAADGQTA GEGASISLYT KPSMVLNLKA EYVTMTSVNL 

       730        740        750        760        770        780 
TWMVNDAESA SYTYRIEVAH ESLINETMSN VTKSIVTYLI PGTSYNFTVF AIAADNQTEG 

       790        800        810        820        830        840 
EGASISQNTV PSSVNAFQCE AVANMSYLTL KWNCPYGGYS GFDIEIFNGT WTKKQQSQFC 

       850        860        870        880        890        900 
GREGSEEIFK TEPLDYYKTY TVSVTTVSDG LTSLPVQKIC KTSITDPPVP NKAPLVKAVS 

       910        920        930        940        950        960 
HNSLSVEFPD FESVNGPLKA YAVMIVTEAE GCLPSKSDLD YTYNDFKQKM TATYVTYVID 

       970        980        990       1000       1010       1020 
VEEISSSSHS QNGHNIVDVG KGNTMYGYEN GPLIPLHSYR ASVAGFTNIN FTVANKIMGE 

      1030       1040       1050       1060       1070       1080 
QSYVSFSPCS EVVSLPQDPG VIAGAVIGCL LAILAVVAIG GYIFWRRRRK DKRNTEVSFS 

      1090       1100       1110       1120       1130       1140 
PIKIKKSKMI KVENFESYFK KQQADSNCGF AEEYEELKSA GVHQPKFAAE IAENRGKNRY 

      1150       1160       1170       1180       1190       1200 
NNVLPYDISR VKLSNPSCTT DDYINANYMP GYSSKKAFIA AQGPLPNTIE DFWRMIWEKN 

      1210       1220       1230       1240       1250       1260 
IYSIVMLTKC VEQARTKCEQ YWPDKQSKSY GDIIVTMVSE VVLPEWTIRD FNVENADTME 

      1270       1280       1290       1300       1310       1320 
SHTVRQFHFT SWPDHGVPET TDLLINFRHL VHEYSSQNPI DSPILVHCSA GVGRTGTFIA 

      1330       1340       1350       1360       1370       1380 
IDRLIQQIEM ENTVDVYGVV YDLRMHRPLM VQTEDQYVFL NQCVMDIIRS QKEKKTDLIY 

      1390       1400 
QNTTAMAIYE NFTPGPAFGK ANGYHA

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References

[1]"The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear."
Kruger R.P., Goodyear R.J., Legan P.K., Warchol M.E., Raphael Y., Cotanche D.A., Richardson G.P.
J. Neurosci. 19:4815-4827(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ238216 mRNA. Translation: CAB41885.2.
IPIIPI00584299.
RefSeqNP_989952.1. NM_204621.1.
UniGeneGga.966.

3D structure databases

HSSPHSSP built from PDB template 2CFV based on UniProtKB Q12913.
ProteinModelPortalQ9W6V5.
SMRQ9W6V5. Positions 1088-1380.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395330.
KEGGgga:395330.

Organism-specific databases

CTD5795.

Phylogenomic databases

HOVERGENHBG053761.
KOK05698.

Family and domain databases

Gene3D2.60.40.10. 9 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 8 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 9 hits.
PROSITEPS50853. FN3. 10 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815415.

Entry information

Entry namePTPRJ_CHICK
AccessionPrimary (citable) accession number: Q9W6V5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2001
Last modified: April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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