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Protein

Receptor-type tyrosine-protein phosphatase eta

Gene

PTPRJ

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates. Plays a role in cell adhesion, migration, proliferation and differentiation (By similarity). May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells.By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1274SubstrateBy similarity1
Active sitei1308Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1352SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase eta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase eta
Short name:
R-PTP-eta
Alternative name(s):
HPTP eta
Protein-tyrosine phosphatase receptor type J
Short name:
R-PTP-J
Supporting-cell antigen
Gene namesi
Name:PTPRJ
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1044ExtracellularSequence analysisAdd BLAST1020
Transmembranei1045 – 1065HelicalSequence analysisAdd BLAST21
Topological domaini1066 – 1406CytoplasmicSequence analysisAdd BLAST341

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500006517325 – 1406Receptor-type tyrosine-protein phosphatase etaAdd BLAST1382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi281N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Glycosylationi332N-linked (GlcNAc...)Sequence analysis1
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi453N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1
Glycosylationi510N-linked (GlcNAc...)Sequence analysis1
Glycosylationi547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Glycosylationi636N-linked (GlcNAc...)Sequence analysis1
Glycosylationi651N-linked (GlcNAc...)Sequence analysis1
Glycosylationi657N-linked (GlcNAc...)Sequence analysis1
Glycosylationi719N-linked (GlcNAc...)Sequence analysis1
Glycosylationi745N-linked (GlcNAc...)Sequence analysis1
Glycosylationi750N-linked (GlcNAc...)Sequence analysis1
Glycosylationi766N-linked (GlcNAc...)Sequence analysis1
Glycosylationi776N-linked (GlcNAc...)Sequence analysis1
Glycosylationi804N-linked (GlcNAc...)Sequence analysis1
Glycosylationi828N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1010N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Found on the apical surfaces of retinal Mueller cells, renal tubule cells and intestinal brush border cells.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9W6V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 170Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini171 – 259Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini260 – 343Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST84
Domaini346 – 437Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST92
Domaini438 – 523Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST86
Domaini524 – 614Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini615 – 703Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST89
Domaini704 – 793Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST90
Domaini794 – 888Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST95
Domaini887 – 979Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST93
Domaini1110 – 1367Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1308 – 1314Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1066 – 1069Poly-Arg4

Sequence similaritiesi

Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053761.
InParanoidiQ9W6V5.
KOiK05698.
PhylomeDBiQ9W6V5.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 9 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W6V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLPLLPPC PLLLLLLLPA EVRCTTACTD DCSLKNVTEE MGTSSNDELS
60 70 80 90 100
VNATSGNRRL SEDVSLPGRA MSDQNSVAQP RAVLDLKTEY VGVTSVNLTW
110 120 130 140 150
TVNDTASDSY TYRIEVRNGS SINNKTSDIT DAEITGLIPG TLYTFTVFAV
160 170 180 190 200
AADGQTAGEG ASISLYTKPS PVLDLKAEYV GVTSVNLTWT VNDTASASYT
210 220 230 240 250
YRIEVTSDSS IDSLTSSVTM AEITGLIPGT LYSFKVFAVA ADNRTEADGA
260 270 280 290 300
SISLYTKPSP VLDLKAEYVG VTSVNLTWTV NGTALTAYTY RIEVRNATSI
310 320 330 340 350
RNETSNINKI EITGLIPGTS YNFKVFATPV NNTTEEEGLS LNLYTKPSPV
360 370 380 390 400
LRVVTEYVGV TSVNLTWMVD DTASDSYTYR IEVRNGSSIN NKTSDITDAE
410 420 430 440 450
ITGLIPGTLY TFTVFAVAAD GQTAGEGASI SLYTKPSPVL DLKAEYVGVT
460 470 480 490 500
SVNLTWTVND TASASYTYRI EVTSDSSIDS LTSNVTMAEI TGLIPGTLYN
510 520 530 540 550
FTVFAVAADN RTEADGAFTS LYTKPTPVTD LKAEHGVTSV SLNWMVNDTA
560 570 580 590 600
SDSYTYRIEV RNGHSVNNKT SNIPETEITG LNPGTLYTFT VFAVAADGET
610 620 630 640 650
EGEGASISVY TKPRAVLHLK TEYVGVTSVN LTWTVNDTDS ASYTYRIEVR
660 670 680 690 700
NGSSINNKTS DITDAEITGL DPGTLYIFTV FAVAADGQTA GEGASISLYT
710 720 730 740 750
KPSMVLNLKA EYVTMTSVNL TWMVNDAESA SYTYRIEVAH ESLINETMSN
760 770 780 790 800
VTKSIVTYLI PGTSYNFTVF AIAADNQTEG EGASISQNTV PSSVNAFQCE
810 820 830 840 850
AVANMSYLTL KWNCPYGGYS GFDIEIFNGT WTKKQQSQFC GREGSEEIFK
860 870 880 890 900
TEPLDYYKTY TVSVTTVSDG LTSLPVQKIC KTSITDPPVP NKAPLVKAVS
910 920 930 940 950
HNSLSVEFPD FESVNGPLKA YAVMIVTEAE GCLPSKSDLD YTYNDFKQKM
960 970 980 990 1000
TATYVTYVID VEEISSSSHS QNGHNIVDVG KGNTMYGYEN GPLIPLHSYR
1010 1020 1030 1040 1050
ASVAGFTNIN FTVANKIMGE QSYVSFSPCS EVVSLPQDPG VIAGAVIGCL
1060 1070 1080 1090 1100
LAILAVVAIG GYIFWRRRRK DKRNTEVSFS PIKIKKSKMI KVENFESYFK
1110 1120 1130 1140 1150
KQQADSNCGF AEEYEELKSA GVHQPKFAAE IAENRGKNRY NNVLPYDISR
1160 1170 1180 1190 1200
VKLSNPSCTT DDYINANYMP GYSSKKAFIA AQGPLPNTIE DFWRMIWEKN
1210 1220 1230 1240 1250
IYSIVMLTKC VEQARTKCEQ YWPDKQSKSY GDIIVTMVSE VVLPEWTIRD
1260 1270 1280 1290 1300
FNVENADTME SHTVRQFHFT SWPDHGVPET TDLLINFRHL VHEYSSQNPI
1310 1320 1330 1340 1350
DSPILVHCSA GVGRTGTFIA IDRLIQQIEM ENTVDVYGVV YDLRMHRPLM
1360 1370 1380 1390 1400
VQTEDQYVFL NQCVMDIIRS QKEKKTDLIY QNTTAMAIYE NFTPGPAFGK

ANGYHA
Length:1,406
Mass (Da):154,214
Last modified:October 1, 2001 - v2
Checksum:i2D609885CC0F367B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238216 mRNA. Translation: CAB41885.2.
RefSeqiNP_989952.1. NM_204621.1.
UniGeneiGga.966.

Genome annotation databases

GeneIDi395330.
KEGGigga:395330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238216 mRNA. Translation: CAB41885.2.
RefSeqiNP_989952.1. NM_204621.1.
UniGeneiGga.966.

3D structure databases

ProteinModelPortaliQ9W6V5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395330.
KEGGigga:395330.

Organism-specific databases

CTDi5795.

Phylogenomic databases

HOVERGENiHBG053761.
InParanoidiQ9W6V5.
KOiK05698.
PhylomeDBiQ9W6V5.

Miscellaneous databases

PROiQ9W6V5.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 9 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRJ_CHICK
AccessioniPrimary (citable) accession number: Q9W6V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.