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Q9W6V5

- PTPRJ_CHICK

UniProt

Q9W6V5 - PTPRJ_CHICK

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Protein
Receptor-type tyrosine-protein phosphatase eta
Gene
PTPRJ
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates. Plays a role in cell adhesion, migration, proliferation and differentiation By similarity. May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1274 – 12741Substrate By similarity
Active sitei1308 – 13081Phosphocysteine intermediate By similarity
Binding sitei1352 – 13521Substrate By similarity

GO - Molecular functioni

  1. phosphatase activity Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. negative regulation of MAP kinase activity Source: UniProtKB
  2. negative regulation of T cell receptor signaling pathway Source: UniProtKB
  3. negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  4. negative regulation of protein kinase B signaling Source: UniProtKB
  5. platelet-derived growth factor receptor signaling pathway Source: UniProtKB
  6. positive regulation of cell adhesion Source: UniProtKB
  7. positive regulation of focal adhesion assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase eta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase eta
Short name:
R-PTP-eta
Alternative name(s):
HPTP eta
Protein-tyrosine phosphatase receptor type J
Short name:
R-PTP-J
Supporting-cell antigen
Gene namesi
Name:PTPRJ
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 10441020Extracellular Reviewed prediction
Add
BLAST
Transmembranei1045 – 106521Helical; Reviewed prediction
Add
BLAST
Topological domaini1066 – 1406341Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
  4. ruffle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 14061382Receptor-type tyrosine-protein phosphatase eta
PRO_5000065173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi124 – 1241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi243 – 2431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi275 – 2751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi332 – 3321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi364 – 3641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi385 – 3851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi453 – 4531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi459 – 4591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi484 – 4841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi547 – 5471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi568 – 5681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi630 – 6301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi636 – 6361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi651 – 6511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi657 – 6571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi719 – 7191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi745 – 7451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi750 – 7501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi766 – 7661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi776 – 7761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi804 – 8041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi828 – 8281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1010 – 10101N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Found on the apical surfaces of retinal Mueller cells, renal tubule cells and intestinal brush border cells.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9W6V5.
SMRiQ9W6V5. Positions 1088-1380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17089Fibronectin type-III 1
Add
BLAST
Domaini171 – 25989Fibronectin type-III 2
Add
BLAST
Domaini260 – 34384Fibronectin type-III 3
Add
BLAST
Domaini346 – 43792Fibronectin type-III 4
Add
BLAST
Domaini438 – 52386Fibronectin type-III 5
Add
BLAST
Domaini524 – 61491Fibronectin type-III 6
Add
BLAST
Domaini615 – 70389Fibronectin type-III 7
Add
BLAST
Domaini704 – 79390Fibronectin type-III 8
Add
BLAST
Domaini794 – 88895Fibronectin type-III 9
Add
BLAST
Domaini887 – 97993Fibronectin type-III 10
Add
BLAST
Domaini1110 – 1367258Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1308 – 13147Substrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1066 – 10694Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053761.
KOiK05698.
PhylomeDBiQ9W6V5.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 8 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W6V5-1 [UniParc]FASTAAdd to Basket

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MRRLPLLPPC PLLLLLLLPA EVRCTTACTD DCSLKNVTEE MGTSSNDELS     50
VNATSGNRRL SEDVSLPGRA MSDQNSVAQP RAVLDLKTEY VGVTSVNLTW 100
TVNDTASDSY TYRIEVRNGS SINNKTSDIT DAEITGLIPG TLYTFTVFAV 150
AADGQTAGEG ASISLYTKPS PVLDLKAEYV GVTSVNLTWT VNDTASASYT 200
YRIEVTSDSS IDSLTSSVTM AEITGLIPGT LYSFKVFAVA ADNRTEADGA 250
SISLYTKPSP VLDLKAEYVG VTSVNLTWTV NGTALTAYTY RIEVRNATSI 300
RNETSNINKI EITGLIPGTS YNFKVFATPV NNTTEEEGLS LNLYTKPSPV 350
LRVVTEYVGV TSVNLTWMVD DTASDSYTYR IEVRNGSSIN NKTSDITDAE 400
ITGLIPGTLY TFTVFAVAAD GQTAGEGASI SLYTKPSPVL DLKAEYVGVT 450
SVNLTWTVND TASASYTYRI EVTSDSSIDS LTSNVTMAEI TGLIPGTLYN 500
FTVFAVAADN RTEADGAFTS LYTKPTPVTD LKAEHGVTSV SLNWMVNDTA 550
SDSYTYRIEV RNGHSVNNKT SNIPETEITG LNPGTLYTFT VFAVAADGET 600
EGEGASISVY TKPRAVLHLK TEYVGVTSVN LTWTVNDTDS ASYTYRIEVR 650
NGSSINNKTS DITDAEITGL DPGTLYIFTV FAVAADGQTA GEGASISLYT 700
KPSMVLNLKA EYVTMTSVNL TWMVNDAESA SYTYRIEVAH ESLINETMSN 750
VTKSIVTYLI PGTSYNFTVF AIAADNQTEG EGASISQNTV PSSVNAFQCE 800
AVANMSYLTL KWNCPYGGYS GFDIEIFNGT WTKKQQSQFC GREGSEEIFK 850
TEPLDYYKTY TVSVTTVSDG LTSLPVQKIC KTSITDPPVP NKAPLVKAVS 900
HNSLSVEFPD FESVNGPLKA YAVMIVTEAE GCLPSKSDLD YTYNDFKQKM 950
TATYVTYVID VEEISSSSHS QNGHNIVDVG KGNTMYGYEN GPLIPLHSYR 1000
ASVAGFTNIN FTVANKIMGE QSYVSFSPCS EVVSLPQDPG VIAGAVIGCL 1050
LAILAVVAIG GYIFWRRRRK DKRNTEVSFS PIKIKKSKMI KVENFESYFK 1100
KQQADSNCGF AEEYEELKSA GVHQPKFAAE IAENRGKNRY NNVLPYDISR 1150
VKLSNPSCTT DDYINANYMP GYSSKKAFIA AQGPLPNTIE DFWRMIWEKN 1200
IYSIVMLTKC VEQARTKCEQ YWPDKQSKSY GDIIVTMVSE VVLPEWTIRD 1250
FNVENADTME SHTVRQFHFT SWPDHGVPET TDLLINFRHL VHEYSSQNPI 1300
DSPILVHCSA GVGRTGTFIA IDRLIQQIEM ENTVDVYGVV YDLRMHRPLM 1350
VQTEDQYVFL NQCVMDIIRS QKEKKTDLIY QNTTAMAIYE NFTPGPAFGK 1400
ANGYHA 1406
Length:1,406
Mass (Da):154,214
Last modified:October 1, 2001 - v2
Checksum:i2D609885CC0F367B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238216 mRNA. Translation: CAB41885.2.
RefSeqiNP_989952.1. NM_204621.1.
UniGeneiGga.966.

Genome annotation databases

GeneIDi395330.
KEGGigga:395330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238216 mRNA. Translation: CAB41885.2 .
RefSeqi NP_989952.1. NM_204621.1.
UniGenei Gga.966.

3D structure databases

ProteinModelPortali Q9W6V5.
SMRi Q9W6V5. Positions 1088-1380.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395330.
KEGGi gga:395330.

Organism-specific databases

CTDi 5795.

Phylogenomic databases

HOVERGENi HBG053761.
KOi K05698.
PhylomeDBi Q9W6V5.

Miscellaneous databases

NextBioi 20815415.
PROi Q9W6V5.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 8 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear."
    Kruger R.P., Goodyear R.J., Legan P.K., Warchol M.E., Raphael Y., Cotanche D.A., Richardson G.P.
    J. Neurosci. 19:4815-4827(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Intestine.

Entry informationi

Entry nameiPTPRJ_CHICK
AccessioniPrimary (citable) accession number: Q9W6V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2001
Last modified: June 11, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi