Reviewed, UniProtKB/Swiss-Prot Q9W6S5 (ALLC_XENLA)

Names and origin

Protein names

Recommended name:
    Allantoicase
    EC=3.5.3.4
Alternative name(s):
    Allantoate amidinohydrolase

Gene names

Name:

allc

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Utilization of purines as secondary nitrogen sources, when primary sources are limiting. Ref.1
Catalytic activity	Allantoate + H2O = (S)-ureidoglycolate + urea.
Pathway	Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
Tissue specificity	Abundantly expressed in kidney and liver, but at much lower level is also present in brain, testis, intestine and lung. Ref.1
Sequence similarities	Belongs to the allantoicase family.

Ontologies

Keywords
Biological process	Purine metabolism
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	allantoicase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Allantoicase		PRO_0000205910
Experimental info
	Sequence conflict	111	1	I → V in AAH60404. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9W6S5-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: C62EBC2AD3A2875F	FASTA	389	43,764
	10 20 30 40 50 60 MFAHPKENIA LPVPEFLQMN NLACESVGGK VLFATDDWFA PAEHLLKKTE PEFKVGLFTE 70 80 90 100 110 120 FGKWMDGWET RRKRIPGHDW CIIQLGVPGI IHGFEADTRF FTGNYAPRIS IQAACLKPEE 130 140 150 160 170 180 ITLQPREDKI GTAASDEEFK AADKLKSEKW SHLLKMTELK PGYAESSHSY FQVNSKERWT 190 200 210 220 230 240 HLRLNIYPDG GIARFKVYGI GQRDWTSCGP NDFEDLLSMV NGGVCLGFSD AHYGHPRNLI 250 260 270 280 290 300 GNGRACDMGD GWETARRLDR PPILKADSKG ILQVPGFEWA VLKLGHPGLV THIEIDTNHF 310 320 330 340 350 360 KGNSPNSCKI DACALKPTEQ EEVKGHGNFE QGYNWKPLLP VTQIHPHKRH FMESTSLALH 370 380 QVISHVKITI APDGGVSRIR LWGFPRPLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Xenopus allantoicase: molecular cloning, enzymatic activity and developmental expression." Vigetti D., Monetti C., Pollegioni L., Taramelli R., Bernardini G. Arch. Biochem. Biophys. 379:90-96(2000) [PubMed: 10864446] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Brain, Kidney and Liver.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF153230 mRNA. Translation: AAD34169.1. BC060404 mRNA. Translation: AAH60404.1.
RefSeq	NP_001083467.1.
UniGene	Xl.653
3D structure databases
SMR	Q9W6S5. Positions 16-384.
ModBase	Search...
Genome annotation databases
GeneID	398942.
KEGG	xla:398942.
Organism-specific databases
Xenbase	XB-FEAT-1002642. allc.
Phylogenomic databases
HOVERGEN	Q9W6S5.
Enzyme and pathway databases
BRENDA	3.5.3.4. 648.
Family and domain databases
InterPro	IPR005164. Allantoicase. IPR015908. Allantoicase_dom. IPR008979. Galactose-bd-like. [Graphical view]
PANTHER	PTHR12045. Allantoicase. 1 hit.
Pfam	PF03561. Allantoicase. 2 hits. [Graphical view]
PIRSF	PIRSF016516. Allantoicase. 1 hit.
TIGRFAMs	TIGR02961. allantoicase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALLC_XENLA

Accession

Primary (citable) accession number: Q9W6S5
Secondary accession number(s): Q6PA96

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project