Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Lefty2

Gene

lft2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell growth Source: InterPro
  • heart field specification Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Lefty2Imported
Submitted name:
Signaling molecule lefty2Imported
Gene namesi
Name:lft2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990630-11. lft2.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 362343Sequence analysisPRO_5005372283Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064677.

Structurei

3D structure databases

ProteinModelPortaliQ9W6I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini254 – 355102TGF_BETA_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000113317.
HOVERGENiHBG074429.
KOiK04668.
PhylomeDBiQ9W6I7.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR003942. LRDF.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037402. TGFb4. 1 hit.
PRINTSiPR01427. TGFBETA4.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W6I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFIQLFIL TTAISLTQGF QHEDIKQALL QKLGLTEPPR IQKRDLENLV
60 70 80 90 100
VPAHIKSKYL SMLKLHHQRR RRSLPSLAGI LRGIHGNADI TGEIKYSDTT
110 120 130 140 150
RQRLVFDMEA RLQENTEVTM AELKLFQTAA QSPSKPERRH HRPINHARVS
160 170 180 190 200
IYWVEVLENG SNRTSLLDSR LVPIHESGWR SFDVTQAIHY WSKSQKKAPL
210 220 230 240 250
HLEVWTEGER PGSYAAEMAK RVRFATQDPK ENTLEKDMGA PELVLYTLDL
260 270 280 290 300
DEYGSQGNCN SSPNSSKCCR EEHFINFREL TWTQYWIIEP AGYQAFRCAG
310 320 330 340 350
GCKQPKRGFY GYGQRTCAVM ESAPLPMMYL VKKGDYTEIE VAEFPNMIVE
360
KCGCSMDKIP PV
Length:362
Mass (Da):41,460
Last modified:November 1, 1999 - v1
Checksum:i0C12BBCB3CEB6007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132445 mRNA. Translation: AAD34389.1.
BC097092 mRNA. Translation: AAH97092.1.
RefSeqiNP_571036.1. NM_130961.1.
UniGeneiDr.80504.

Genome annotation databases

GeneIDi30146.
KEGGidre:30146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132445 mRNA. Translation: AAD34389.1.
BC097092 mRNA. Translation: AAH97092.1.
RefSeqiNP_571036.1. NM_130961.1.
UniGeneiDr.80504.

3D structure databases

ProteinModelPortaliQ9W6I7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30146.
KEGGidre:30146.

Organism-specific databases

CTDi30146.
ZFINiZDB-GENE-990630-11. lft2.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000113317.
HOVERGENiHBG074429.
KOiK04668.
PhylomeDBiQ9W6I7.

Miscellaneous databases

NextBioi20806621.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR003942. LRDF.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037402. TGFb4. 1 hit.
PRINTSiPR01427. TGFBETA4.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of midline development by antagonism of lefty and nodal signaling."
    Bisgrove B.W., Essner J.J., Yost H.J.
    Development 126:3253-3262(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiQ9W6I7_DANRE
AccessioniPrimary (citable) accession number: Q9W6I7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.