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UniProtKB - Q9W6I6 (Q9W6I6_DANRE)

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Protein
Submitted name:

Lefty1

Gene

lft1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

  • BMP signaling pathway Source: GO_Central
  • cell development Source: GO_Central
  • cell growth Source: InterPro
  • determination of heart left/right asymmetry Source: ZFIN
  • determination of left/right asymmetry in diencephalon Source: ZFIN
  • determination of left/right asymmetry in lateral mesoderm Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • SMAD protein signal transduction Source: GO_Central
Complete GO annotation...

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Lefty1Imported
Submitted name:
Signaling molecule lefty1Imported
Gene namesi
Name:lft1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-990630-10. lft1.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501014985221 – 358Sequence analysisAdd BLAST338

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000019920.

Interactioni

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

DIPiDIP-46065N.
STRINGi7955.ENSDARP00000005312.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 351TGF_BETA_2InterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000010056.
HOVERGENiHBG074429.
OMAiETGWKSF.
OrthoDBiEOG091G09EN.
TreeFamiTF106462.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR003942. LRDF.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
PIRSFiPIRSF037402. TGFb4. 1 hit.
PRINTSiPR01427. TGFBETA4.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9W6I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVRAACLL CAALFAMARG FTHEDMKDAL LKKLGLNEIP QIHKRDLENL 
        60         70         80         90        100
VIPTNVKNKY ISMLKLHHSR KRRSLPSLAG ILRGIPGNAD ISGEFVYSDT 
       110        120        130        140        150
TRQRVVFEMT SRIPENSEVT MAELKLYKKA PHKRSIPERK GHRPVNNARV 
       160        170        180        190        200
SIYWVEPQKD GSNRTSLVDS RLIPIHETGW KSFDVTQAVQ YWSRSRMEMP 
       210        220        230        240        250
MHLEVWIEGE RPGSYAAEMA KCVHFTTQDP DDNTLGKPEL VLYTLNLEEF 
       260        270        280        290        300
GSSGDCENNK DREMCCREQY FINFRALTWT QYWIIEPSGY QAFRCKGGCR 
       310        320        330        340        350
QPKRNYGYGE RKCAVVESAP LPMMYLVKKG DYTEIEVAEF PNMIVEKCGC 

AMDNISVV
Length:358
Mass (Da):41,018
Last modified:November 1, 1999 - v1
Checksum:iF7A86FE828092AA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470246 Genomic DNA. No translation available.
AF132444 mRNA. Translation: AAD34388.1.
UniGeneiDr.81291.

Genome annotation databases

EnsembliENSDART00000019196; ENSDARP00000005312; ENSDARG00000019920.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9W6I6_DANRE
AccessioniPrimary (citable) accession number: Q9W6I6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported