UniProtKB - Q9W6I6 (Q9W6I6_DANRE)
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Protein
Submitted name:
Lefty1
Gene
lft1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: GO_Central
GO - Biological processi
- BMP signaling pathway Source: GO_Central
- cell development Source: GO_Central
- cell growth Source: InterPro
- determination of heart left/right asymmetry Source: ZFIN
- determination of left/right asymmetry in diencephalon Source: ZFIN
- determination of left/right asymmetry in lateral mesoderm Source: ZFIN
- determination of left/right symmetry Source: ZFIN
- dorsal/ventral pattern formation Source: ZFIN
- embryonic heart tube development Source: ZFIN
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- regulation of apoptotic process Source: GO_Central
- regulation of MAPK cascade Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Growth factorUniRule annotationSAAS annotation |
Enzyme and pathway databases
Reactomei | R-DRE-114608. Platelet degranulation. |
Names & Taxonomyi
Protein namesi | Submitted name: Lefty1ImportedSubmitted name: Signaling molecule lefty1Imported |
Gene namesi | Name:lft1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-990630-10. lft1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5014108479 | 21 – 358 | Sequence analysisAdd BLAST | 338 |
Keywords - PTMi
Disulfide bondSAAS annotationInteractioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: GO_Central
Protein-protein interaction databases
DIPi | DIP-46065N. |
IntActi | Q9W6I6. 1 interactor. |
STRINGi | 7955.ENSDARP00000005312. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 248 – 351 | TGF_BETA_2InterPro annotationAdd BLAST | 104 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3900. Eukaryota. ENOG410XT8Z. LUCA. |
GeneTreei | ENSGT00390000010056. |
HOVERGENi | HBG074429. |
OMAi | ETGWKSF. |
OrthoDBi | EOG091G09EN. |
TreeFami | TF106462. |
Family and domain databases
Gene3Di | 2.10.90.10. 1 hit. |
InterProi | View protein in InterPro IPR029034. Cystine-knot_cytokine. IPR003942. LRDF. IPR001839. TGF-b_C. IPR001111. TGF-b_propeptide. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. |
PANTHERi | PTHR11848. PTHR11848. 1 hit. |
Pfami | View protein in Pfam PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. |
PIRSFi | PIRSF037402. TGFb4. 1 hit. |
PRINTSi | PR01427. TGFBETA4. |
SMARTi | View protein in SMART SM00204. TGFB. 1 hit. |
SUPFAMi | SSF57501. SSF57501. 1 hit. |
PROSITEi | View protein in PROSITE PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9W6I6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSVRAACLL CAALFAMARG FTHEDMKDAL LKKLGLNEIP QIHKRDLENL
60 70 80 90 100
VIPTNVKNKY ISMLKLHHSR KRRSLPSLAG ILRGIPGNAD ISGEFVYSDT
110 120 130 140 150
TRQRVVFEMT SRIPENSEVT MAELKLYKKA PHKRSIPERK GHRPVNNARV
160 170 180 190 200
SIYWVEPQKD GSNRTSLVDS RLIPIHETGW KSFDVTQAVQ YWSRSRMEMP
210 220 230 240 250
MHLEVWIEGE RPGSYAAEMA KCVHFTTQDP DDNTLGKPEL VLYTLNLEEF
260 270 280 290 300
GSSGDCENNK DREMCCREQY FINFRALTWT QYWIIEPSGY QAFRCKGGCR
310 320 330 340 350
QPKRNYGYGE RKCAVVESAP LPMMYLVKKG DYTEIEVAEF PNMIVEKCGC
AMDNISVV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX470246 Genomic DNA. No translation available. AF132444 mRNA. Translation: AAD34388.1. |
UniGenei | Dr.81291. |
Genome annotation databases
Ensembli | ENSDART00000019196; ENSDARP00000005312; ENSDARG00000019920. |
Similar proteinsi
Entry informationi
Entry namei | Q9W6I6_DANRE | |
Accessioni | Q9W6I6Primary (citable) accession number: Q9W6I6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1999 |
Last sequence update: | November 1, 1999 | |
Last modified: | March 28, 2018 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |