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Protein

Mimecan

Gene

OGN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-GGA-2022854. Keratan sulfate biosynthesis.
R-GGA-2022857. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Gene namesi
Name:OGN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003276220 – 294MimecanAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi251 ↔ 284By similarity
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The composition of the N-linked chains or the substitution of the N-linked sites is different between embryonic and adult tissues.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9W6H0.
PRIDEiQ9W6H0.

Expressioni

Developmental stagei

Levels decrease at each developmental time point and further decrease during maturation into adulthood.

Gene expression databases

BgeeiENSGALG00000026736.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007525.

Structurei

3D structure databases

ProteinModelPortaliQ9W6H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati108 – 127LRR 1Add BLAST20
Repeati128 – 151LRR 2Add BLAST24
Repeati152 – 175LRR 3Add BLAST24
Repeati176 – 195LRR 4Add BLAST20
Repeati196 – 221LRR 5Add BLAST26
Repeati222 – 242LRR 6Add BLAST21
Repeati243 – 273LRR 7Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 102Cys-richAdd BLAST13

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ9W6H0.
KOiK08126.
OMAiRMDEIRM.
OrthoDBiEOG091G0E49.
PhylomeDBiQ9W6H0.
TreeFamiTF351924.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W6H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLQAAFFL VAFVPLVKPA PPIQQDSPKF YEYVDADFAT GSLIQQDYEM
60 70 80 90 100
LPKDTIKDGT NVSLDTALRL QADDSELSAR PTKDTNLPTC LLCVCLSGSV
110 120 130 140 150
YCEEIDIEAV PPLPKETAYL YARFNKIKRI AVSDFADITT LRRIDFSGNM
160 170 180 190 200
IEEIEDGAFS KLLLLEELSL AENRLVKLPV LPPKLTTFNA NQNRIKSRGI
210 220 230 240 250
KNNAFKKLTN LAYLYLGHNA LESVPLNLPE SLRILHLQHN NITTINDDTF
260 270 280 290
CKSNNTRYIR TRMDEIRMEG NPILLAKHVN AFSCLRTLPV GTYY
Length:294
Mass (Da):33,179
Last modified:November 1, 1999 - v1
Checksum:i0386701A28A7A6EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126963 mRNA. Translation: AAD21085.1.
RefSeqiNP_989540.1. NM_204209.1.
UniGeneiGga.4194.

Genome annotation databases

EnsembliENSGALT00000045074; ENSGALP00000043060; ENSGALG00000026736.
ENSGALT00000078253; ENSGALP00000047361; ENSGALG00000026736.
GeneIDi374039.
KEGGigga:374039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126963 mRNA. Translation: AAD21085.1.
RefSeqiNP_989540.1. NM_204209.1.
UniGeneiGga.4194.

3D structure databases

ProteinModelPortaliQ9W6H0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007525.

Proteomic databases

PaxDbiQ9W6H0.
PRIDEiQ9W6H0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045074; ENSGALP00000043060; ENSGALG00000026736.
ENSGALT00000078253; ENSGALP00000047361; ENSGALG00000026736.
GeneIDi374039.
KEGGigga:374039.

Organism-specific databases

CTDi4969.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ9W6H0.
KOiK08126.
OMAiRMDEIRM.
OrthoDBiEOG091G0E49.
PhylomeDBiQ9W6H0.
TreeFamiTF351924.

Enzyme and pathway databases

ReactomeiR-GGA-2022854. Keratan sulfate biosynthesis.
R-GGA-2022857. Keratan sulfate degradation.

Miscellaneous databases

PROiQ9W6H0.

Gene expression databases

BgeeiENSGALG00000026736.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIME_CHICK
AccessioniPrimary (citable) accession number: Q9W6H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.