AR - Androgen receptor - Haplochromis burtoni (Burton's mouthbrooder)

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	306 – 381	Nuclear receptorPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro
steroid hormone receptor activity Source: InterPro
transcription factor activity, sequence-specific DNA binding Source: InterPro
zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Androgen receptorImported
Gene namesⁱ	Name:ARImported
Organismⁱ	Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni)Imported
Taxonomic identifierⁱ	8153 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Osteoglossocephalai › Clupeocephala › Euteleosteomorpha › Neoteleostei › Eurypterygia › Ctenosquamata › Acanthomorphata › Euacanthomorphacea › Percomorphaceae › Ovalentaria › Cichlomorphae › Cichliformes › Cichlidae › African cichlids › Pseudocrenilabrinae › Haplochromini › Haplochromis

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Automatic assertion according to rulesⁱ
- PROSITE-ProRule:PRU00407
- RuleBase:RU004334
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00817906

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9W6F4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	306 – 381	Nuclear receptor DNA-bindingInterPro annotationAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOVERGENⁱ	HBG007583.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G032J.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000536. Nucl_hrmn_rcpt_lig-bd. IPR001723. Nuclear_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit.
PRINTSⁱ	PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMARTⁱ	View protein in SMART SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit.
SUPFAMⁱ	SSF48508. SSF48508. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9W6F4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSFHSVLEGT NSLTMNEGDR LDTTIYACPA YELSKAVSVS LGLDSVSSPP 
        60         70         80         90        100
NNMNQSSSSA FAECDSTVAD TSRGVPELRR TGNMNSDSSL LVLGDSSLRE 
       110        120        130        140        150
DDFGEVCQGI QQVSCMDLFG SGEMDGAQTV TRGSVISRYV CRESNVFMNP 
       160        170        180        190        200
TLELPATPQV AEVVPLKPPS SYYASSDLYR DFPPQMWCAN ERAYIDRSQP 
       210        220        230        240        250
QPQPQPQRGE SGEHNFLCKY CNCGQAPRGN RQECRCIWYG RGEKGGKGGM 
       260        270        280        290        300
RATAQGYGQM ESYPSAIPQG QSTFSTIKSE PSVWMNCTDR SLRHEDFFPG 
       310        320        330        340        350
VYLSERRVCQ VCGDDASGCH YGAVTCGSCK VFFKRAAAGK QNHLCASRND 
       360        370        380        390        400
CTIDKLRRKN CASCRLKRCF MSGMSLKGRR LKGTGQASNG EEEQQPASWG 
       410        420        430        440        450
HGEKEERAAK KDAVLESRNA AVRAQGASQA LVAAIPPPLH SCLSLLSILQ 
       460        470        480        490        500
AIEPALVNAG HDPAQPDSPV SLLTSLNELG ERQLVTVVHW AKAIPGFRDL 
       510        520        530        540        550
YVDDQMSLIQ LSWMGVMVFA LGWRSYTLTN SSMLYFAPDL VFNDQRMQVS 
       560        570        580        590        600
SMYEHCVRMK LLSQRLCMLK VTQEEFLCMK ALVLLSIMPV QGLKSQSCFD 
       610        620        630        640        650
KLRTSYIKEL DRLASHHGET TRTQRLFQLT QLLDYLQSVV RKLHQFTYDL 
       660        670        680        690 
FIQAQSMQMH VSFPEMISEI VSVHVPKILS GMVKPILFHN AA

Length:692

Mass (Da):76,698

Last modified:January 10, 2006 - v2

Checksum:ⁱ41C4728DBBEC0AD6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF121257 mRNA. Translation: AAD25074.2.
NCBI Reference Sequences More...RefSeqⁱ	NP_001273265.1. NM_001286336.1.

Genome annotation databases

GeneIDⁱ	102308855.

GeneIDⁱ

102308855.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF121257 mRNA. Translation: AAD25074.2.
NCBI Reference Sequences More...RefSeqⁱ	NP_001273265.1. NM_001286336.1.

3D structure databases

ProteinModelPortalⁱ	Q9W6F4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	102308855.

GeneIDⁱ

102308855.

Organism-specific databases

CTDⁱ	367.

CTDⁱ

367.

Phylogenomic databases

HOVERGENⁱ	HBG007583.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G032J.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000536. Nucl_hrmn_rcpt_lig-bd. IPR001723. Nuclear_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit.
PRINTSⁱ	PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMARTⁱ	View protein in SMART SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit.
SUPFAMⁱ	SSF48508. SSF48508. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9W6F4_HAPBU
Accessionⁱ	Q9W6F4Primary (citable) accession number: Q9W6F4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 1, 1999
	Last sequence update:	January 10, 2006
	Last modified:	June 7, 2017
	This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q9W6F4 (Q9W6F4_HAPBU)

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Androgen receptor

AR

Select a section on the left to see content.

Functionⁱ

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9W6F4 (Q9W6F4_HAPBU)

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Androgen receptor

AR

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ