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Protein
Submitted name:

Frizzled homolog 10

Gene

fzd10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GO_Central
  2. Wnt-activated receptor activity Source: ZFIN
  3. Wnt-protein binding Source: GO_Central

GO - Biological processi

  1. canonical Wnt signaling pathway Source: GO_Central
  2. epiboly Source: ZFIN
  3. G-protein coupled receptor signaling pathway Source: GOC
  4. multicellular organismal development Source: UniProtKB-KW
  5. non-canonical Wnt signaling pathway Source: GO_Central
  6. Wnt signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotation, ReceptorSAAS annotation

Keywords - Biological processi

Wnt signaling pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Frizzled homolog 10Imported
Submitted name:
Frizzled proteinImported
Submitted name:
Fzd10 proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:fzd10Imported
Synonyms:fz4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-990415-220. fzd10.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118864.
HOVERGENiHBG006977.
KOiK02842.
OMAiQSWQNVC.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W6E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAAGVGLSL GLLCFAGFCS AISSIDPDRP GEGRCQEIAI PLCKDIGYNL
60 70 80 90 100
TVMPNLMGHE DQNEAAIKLH EFAPLIEFGC HSHLKFFLCS LYAPMCTEQV
110 120 130 140 150
STPIPACRVM CEQARQKCSP IMEQFNFHWP ESLDCSRLPN KNDPNYLCME
160 170 180 190 200
APNNGTDEPP KGSHTQSPDS RPPRPGNSQE LPIKERVGKT TCSNPGKFHY
210 220 230 240 250
VQKSESCAPK CYSNVDVYWS QGDKRFSMVW IAIWSILCFI SSAFTVLTFL
260 270 280 290 300
IDPQRFKYPE RPIIFLSMSY CVYSVGFLVR LFVGVENVAC DRDTGVQYII
310 320 330 340 350
QEGLESTGCT IVFLILYYFG MASSLWWVIL TLTWFLAAGK KWGHEAIEAN
360 370 380 390 400
SSYFHLAAWA IPAIKTIMIL VMRKVAGDEL TGVCYVGSMD VKALTGFVLI
410 420 430 440 450
PLSCYLIIGT SFLLSGFVAL FHIRKVMKTE GENTDKLEKL MVRIGVFSVL
460 470 480 490 500
YTVPATCVIA CYFYERLNMD YWKILAGEQK CADDGKSGEE CVMKSSIPAV
510 520 530 540 550
EIFMVKIFML LVVGITSGMW IWTSKTLQSW QNVFSRKLKK KTRRKAACVF
560 570 580
TGSGPYLKPH PALKGHKTKY EPAGPPATCV
Length:580
Mass (Da):64,857
Last modified:November 1, 1999 - v1
Checksum:i8615F3555830B11C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU914776 Genomic DNA. No translation available.
AF117388 mRNA. Translation: AAD25358.1.
BC076546 mRNA. Translation: AAH76546.1.
BC165721 mRNA. Translation: AAI65721.1.
RefSeqiNP_570992.2. NM_130917.2.
UniGeneiDr.80513.

Genome annotation databases

EnsembliENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
GeneIDi30366.
KEGGidre:30366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU914776 Genomic DNA. No translation available.
AF117388 mRNA. Translation: AAD25358.1.
BC076546 mRNA. Translation: AAH76546.1.
BC165721 mRNA. Translation: AAI65721.1.
RefSeqiNP_570992.2. NM_130917.2.
UniGeneiDr.80513.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
GeneIDi30366.
KEGGidre:30366.

Organism-specific databases

CTDi11211.
ZFINiZDB-GENE-990415-220. fzd10.

Phylogenomic databases

GeneTreeiENSGT00760000118864.
HOVERGENiHBG006977.
KOiK02842.
OMAiQSWQNVC.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Miscellaneous databases

NextBioi20806788.
PROiQ9W6E3.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of zebrafish frizzled genes."
    Furutani-Seiki M.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: WholeImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ9W6E3_DANRE
AccessioniPrimary (citable) accession number: Q9W6E3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: March 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.