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Q9W6E3 (Q9W6E3_DANRE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Frizzled protein EMBL AAD25358.1

Fzd10 protein EMBL AAI65721.1

Uncharacterized protein Ensembl ENSDARP00000089291
Gene names
Name:fzd10 Ensembl ENSDARP00000089291 ZFIN ZDB-GENE-990415-220 EMBL AAH76546.1
Synonyms:fz4 EMBL AAD25358.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains FZ (frizzled) domain. SAAS SAAS017981

Ontologies

Keywords
   Biological processWnt signaling pathway SAAS SAAS020067
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS020067
   Molecular functionDevelopmental protein SAAS SAAS020067
Receptor SAAS SAAS020067
   PTMDisulfide bond SAAS SAAS017981
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from mutant phenotype PubMed 12676325. Source: ZFIN

brain development

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

epiboly

Inferred from genetic interaction PubMed 23349976. Source: ZFIN

gonad development

Inferred from Biological aspect of Ancestor. Source: RefGenome

vasculature development

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcell projection

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

PDZ domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated receptor activity

Inferred from mutant phenotype PubMed 12676325. Source: ZFIN

Wnt-protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9W6E3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8615F3555830B11C

FASTA58064,857
        10         20         30         40         50         60 
MFAAGVGLSL GLLCFAGFCS AISSIDPDRP GEGRCQEIAI PLCKDIGYNL TVMPNLMGHE 

        70         80         90        100        110        120 
DQNEAAIKLH EFAPLIEFGC HSHLKFFLCS LYAPMCTEQV STPIPACRVM CEQARQKCSP 

       130        140        150        160        170        180 
IMEQFNFHWP ESLDCSRLPN KNDPNYLCME APNNGTDEPP KGSHTQSPDS RPPRPGNSQE 

       190        200        210        220        230        240 
LPIKERVGKT TCSNPGKFHY VQKSESCAPK CYSNVDVYWS QGDKRFSMVW IAIWSILCFI 

       250        260        270        280        290        300 
SSAFTVLTFL IDPQRFKYPE RPIIFLSMSY CVYSVGFLVR LFVGVENVAC DRDTGVQYII 

       310        320        330        340        350        360 
QEGLESTGCT IVFLILYYFG MASSLWWVIL TLTWFLAAGK KWGHEAIEAN SSYFHLAAWA 

       370        380        390        400        410        420 
IPAIKTIMIL VMRKVAGDEL TGVCYVGSMD VKALTGFVLI PLSCYLIIGT SFLLSGFVAL 

       430        440        450        460        470        480 
FHIRKVMKTE GENTDKLEKL MVRIGVFSVL YTVPATCVIA CYFYERLNMD YWKILAGEQK 

       490        500        510        520        530        540 
CADDGKSGEE CVMKSSIPAV EIFMVKIFML LVVGITSGMW IWTSKTLQSW QNVFSRKLKK 

       550        560        570        580 
KTRRKAACVF TGSGPYLKPH PALKGHKTKY EPAGPPATCV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional analysis of zebrafish frizzled genes."
Furutani-Seiki M.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Whole EMBL AAH76546.1.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PCR rescue EMBL AAI65721.1.
[4]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Tuebingen Ensembl ENSDARP00000089291.
[5]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen Ensembl ENSDARP00000089291.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU914776 Genomic DNA. No translation available.
AF117388 mRNA. Translation: AAD25358.1.
BC076546 mRNA. Translation: AAH76546.1.
BC165721 mRNA. Translation: AAI65721.1.
RefSeqNP_570992.2. NM_130917.2.
UniGeneDr.80513.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
GeneID30366.
KEGGdre:30366.

Organism-specific databases

CTD11211.
ZFINZDB-GENE-990415-220. fzd10.

Phylogenomic databases

GeneTreeENSGT00750000117488.
HOVERGENHBG006977.
InParanoidQ9W6E3.
KOK02842.
OMAQSWQNVC.
OrthoDBEOG7M3J01.
TreeFamTF317907.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806788.
PROQ9W6E3.

Entry information

Entry nameQ9W6E3_DANRE
AccessionPrimary (citable) accession number: Q9W6E3
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)