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Q9W6E3

- Q9W6E3_DANRE

UniProt

Q9W6E3 - Q9W6E3_DANRE

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Protein
Submitted name:

Frizzled homolog 10

Gene
fzd10, fz4
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: ZFIN
  4. Wnt-protein binding Source: RefGenome

GO - Biological processi

  1. brain development Source: RefGenome
  2. canonical Wnt signaling pathway Source: RefGenome
  3. epiboly Source: ZFIN
  4. gonad development Source: RefGenome
  5. vasculature development Source: RefGenome
  6. Wnt signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotations, ReceptorSAAS annotations

Keywords - Biological processi

Wnt signaling pathwaySAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Frizzled homolog 10Imported
Submitted name:
Frizzled proteinImported
Submitted name:
Fzd10 proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:fzd10Imported
Synonyms:fz4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-990415-220. fzd10.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: RefGenome
  2. cytoplasm Source: RefGenome
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117488.
HOVERGENiHBG006977.
InParanoidiQ9W6E3.
KOiK02842.
OMAiQSWQNVC.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W6E3-1 [UniParc]FASTAAdd to Basket

« Hide

MFAAGVGLSL GLLCFAGFCS AISSIDPDRP GEGRCQEIAI PLCKDIGYNL    50
TVMPNLMGHE DQNEAAIKLH EFAPLIEFGC HSHLKFFLCS LYAPMCTEQV 100
STPIPACRVM CEQARQKCSP IMEQFNFHWP ESLDCSRLPN KNDPNYLCME 150
APNNGTDEPP KGSHTQSPDS RPPRPGNSQE LPIKERVGKT TCSNPGKFHY 200
VQKSESCAPK CYSNVDVYWS QGDKRFSMVW IAIWSILCFI SSAFTVLTFL 250
IDPQRFKYPE RPIIFLSMSY CVYSVGFLVR LFVGVENVAC DRDTGVQYII 300
QEGLESTGCT IVFLILYYFG MASSLWWVIL TLTWFLAAGK KWGHEAIEAN 350
SSYFHLAAWA IPAIKTIMIL VMRKVAGDEL TGVCYVGSMD VKALTGFVLI 400
PLSCYLIIGT SFLLSGFVAL FHIRKVMKTE GENTDKLEKL MVRIGVFSVL 450
YTVPATCVIA CYFYERLNMD YWKILAGEQK CADDGKSGEE CVMKSSIPAV 500
EIFMVKIFML LVVGITSGMW IWTSKTLQSW QNVFSRKLKK KTRRKAACVF 550
TGSGPYLKPH PALKGHKTKY EPAGPPATCV 580
Length:580
Mass (Da):64,857
Last modified:November 1, 1999 - v1
Checksum:i8615F3555830B11C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU914776 Genomic DNA. No translation available.
AF117388 mRNA. Translation: AAD25358.1.
BC076546 mRNA. Translation: AAH76546.1.
BC165721 mRNA. Translation: AAI65721.1.
RefSeqiNP_570992.2. NM_130917.2.
UniGeneiDr.80513.

Genome annotation databases

EnsembliENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
GeneIDi30366.
KEGGidre:30366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU914776 Genomic DNA. No translation available.
AF117388 mRNA. Translation: AAD25358.1 .
BC076546 mRNA. Translation: AAH76546.1 .
BC165721 mRNA. Translation: AAI65721.1 .
RefSeqi NP_570992.2. NM_130917.2.
UniGenei Dr.80513.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000098520 ; ENSDARP00000089291 ; ENSDARG00000068213 .
GeneIDi 30366.
KEGGi dre:30366.

Organism-specific databases

CTDi 11211.
ZFINi ZDB-GENE-990415-220. fzd10.

Phylogenomic databases

GeneTreei ENSGT00750000117488.
HOVERGENi HBG006977.
InParanoidi Q9W6E3.
KOi K02842.
OMAi QSWQNVC.
OrthoDBi EOG7M3J01.
TreeFami TF317907.

Miscellaneous databases

NextBioi 20806788.
PROi Q9W6E3.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of zebrafish frizzled genes."
    Furutani-Seiki M.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: WholeImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ9W6E3_DANRE
AccessioniPrimary (citable) accession number: Q9W6E3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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