Q9W6E3 (Q9W6E3_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Frizzled homolog 10 EMBL AAH76546.1

Submitted name:
Frizzled protein EMBL AAD25358.1
Submitted name:
Uncharacterized protein Ensembl ENSDARP00000089291

Gene names

Name:	fzd10 Ensembl ENSDARP00000089291 ZFIN ZDB-GENE-990415-220 EMBL AAH76546.1
Synonyms:	fz4 EMBL AAD25358.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	580 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FZ (frizzled) domain. SAAS SAAS015526

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS015526
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS015526
Molecular function	Developmental protein SAAS SAAS015526 G-protein coupled receptor SAAS SAAS015526 Receptor Transducer
PTM	Disulfide bond SAAS SAAS015526
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 12676325. Source: ZFIN epiboly Inferred from genetic interaction PubMed 23349976. Source: ZFIN multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW Wnt-activated receptor activity Inferred from mutant phenotype PubMed 12676325. Source: ZFIN
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9W6E3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8615F3555830B11C	FASTA	580	64,857
	10 20 30 40 50 60 MFAAGVGLSL GLLCFAGFCS AISSIDPDRP GEGRCQEIAI PLCKDIGYNL TVMPNLMGHE 70 80 90 100 110 120 DQNEAAIKLH EFAPLIEFGC HSHLKFFLCS LYAPMCTEQV STPIPACRVM CEQARQKCSP 130 140 150 160 170 180 IMEQFNFHWP ESLDCSRLPN KNDPNYLCME APNNGTDEPP KGSHTQSPDS RPPRPGNSQE 190 200 210 220 230 240 LPIKERVGKT TCSNPGKFHY VQKSESCAPK CYSNVDVYWS QGDKRFSMVW IAIWSILCFI 250 260 270 280 290 300 SSAFTVLTFL IDPQRFKYPE RPIIFLSMSY CVYSVGFLVR LFVGVENVAC DRDTGVQYII 310 320 330 340 350 360 QEGLESTGCT IVFLILYYFG MASSLWWVIL TLTWFLAAGK KWGHEAIEAN SSYFHLAAWA 370 380 390 400 410 420 IPAIKTIMIL VMRKVAGDEL TGVCYVGSMD VKALTGFVLI PLSCYLIIGT SFLLSGFVAL 430 440 450 460 470 480 FHIRKVMKTE GENTDKLEKL MVRIGVFSVL YTVPATCVIA CYFYERLNMD YWKILAGEQK 490 500 510 520 530 540 CADDGKSGEE CVMKSSIPAV EIFMVKIFML LVVGITSGMW IWTSKTLQSW QNVFSRKLKK 550 560 570 580 KTRRKAACVF TGSGPYLKPH PALKGHKTKY EPAGPPATCV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of zebrafish frizzled genes." Furutani-Seiki M. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Whole EMBL AAH76546.1.
[3]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000089291.
[4]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000089291.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU914776 Genomic DNA. No translation available. AF117388 mRNA. Translation: AAD25358.1. BC076546 mRNA. Translation: AAH76546.1.
IPI	IPI00963229.
RefSeq	NP_570992.2. NM_130917.2.
UniGene	Dr.80513.
3D structure databases
HSSP	HSSP built from PDB template 1IJY based on UniProtKB Q61091.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
GeneID	30366.
KEGG	dre:30366.
Organism-specific databases
CTD	11211.
ZFIN	ZDB-GENE-990415-220. fzd10.
Phylogenomic databases
GeneTree	ENSGT00660000095421.
HOVERGEN	HBG006977.
InParanoid	Q9W6E3.
KO	K02842.
Family and domain databases
Gene3D	1.10.2000.10. 1 hit.
InterPro	IPR000539. Frizzled. IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR026549. FZD10. IPR017981. GPCR_2-like. [Graphical view]
PANTHER	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF24. PTHR11309:SF24. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806788.

Entry information

Entry name

Q9W6E3_DANRE

Accession

Primary (citable) accession number: Q9W6E3

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)