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Q9W6E3

- Q9W6E3_DANRE

UniProt

Q9W6E3 - Q9W6E3_DANRE

Protein
Submitted name:

Frizzled homolog 10

Gene

fzd10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. PDZ domain binding Source: RefGenome
    2. Wnt-activated receptor activity Source: ZFIN
    3. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. brain development Source: RefGenome
    2. canonical Wnt signaling pathway Source: RefGenome
    3. epiboly Source: ZFIN
    4. gonad development Source: RefGenome
    5. vasculature development Source: RefGenome
    6. Wnt signaling pathway Source: ZFIN

    Keywords - Molecular functioni

    Developmental proteinSAAS annotation, ReceptorSAAS annotation

    Keywords - Biological processi

    Wnt signaling pathwaySAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Frizzled homolog 10Imported
    Submitted name:
    Frizzled proteinImported
    Submitted name:
    Fzd10 proteinImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:fzd10Imported
    Synonyms:fz4Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 8

    Organism-specific databases

    ZFINiZDB-GENE-990415-220. fzd10.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: RefGenome
    2. cytoplasm Source: RefGenome
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains FZ (frizzled) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117488.
    HOVERGENiHBG006977.
    InParanoidiQ9W6E3.
    KOiK02842.
    OMAiQSWQNVC.
    OrthoDBiEOG7M3J01.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9W6E3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAAGVGLSL GLLCFAGFCS AISSIDPDRP GEGRCQEIAI PLCKDIGYNL    50
    TVMPNLMGHE DQNEAAIKLH EFAPLIEFGC HSHLKFFLCS LYAPMCTEQV 100
    STPIPACRVM CEQARQKCSP IMEQFNFHWP ESLDCSRLPN KNDPNYLCME 150
    APNNGTDEPP KGSHTQSPDS RPPRPGNSQE LPIKERVGKT TCSNPGKFHY 200
    VQKSESCAPK CYSNVDVYWS QGDKRFSMVW IAIWSILCFI SSAFTVLTFL 250
    IDPQRFKYPE RPIIFLSMSY CVYSVGFLVR LFVGVENVAC DRDTGVQYII 300
    QEGLESTGCT IVFLILYYFG MASSLWWVIL TLTWFLAAGK KWGHEAIEAN 350
    SSYFHLAAWA IPAIKTIMIL VMRKVAGDEL TGVCYVGSMD VKALTGFVLI 400
    PLSCYLIIGT SFLLSGFVAL FHIRKVMKTE GENTDKLEKL MVRIGVFSVL 450
    YTVPATCVIA CYFYERLNMD YWKILAGEQK CADDGKSGEE CVMKSSIPAV 500
    EIFMVKIFML LVVGITSGMW IWTSKTLQSW QNVFSRKLKK KTRRKAACVF 550
    TGSGPYLKPH PALKGHKTKY EPAGPPATCV 580
    Length:580
    Mass (Da):64,857
    Last modified:November 1, 1999 - v1
    Checksum:i8615F3555830B11C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU914776 Genomic DNA. No translation available.
    AF117388 mRNA. Translation: AAD25358.1.
    BC076546 mRNA. Translation: AAH76546.1.
    BC165721 mRNA. Translation: AAI65721.1.
    RefSeqiNP_570992.2. NM_130917.2.
    UniGeneiDr.80513.

    Genome annotation databases

    EnsembliENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
    GeneIDi30366.
    KEGGidre:30366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU914776 Genomic DNA. No translation available.
    AF117388 mRNA. Translation: AAD25358.1 .
    BC076546 mRNA. Translation: AAH76546.1 .
    BC165721 mRNA. Translation: AAI65721.1 .
    RefSeqi NP_570992.2. NM_130917.2.
    UniGenei Dr.80513.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000098520 ; ENSDARP00000089291 ; ENSDARG00000068213 .
    GeneIDi 30366.
    KEGGi dre:30366.

    Organism-specific databases

    CTDi 11211.
    ZFINi ZDB-GENE-990415-220. fzd10.

    Phylogenomic databases

    GeneTreei ENSGT00750000117488.
    HOVERGENi HBG006977.
    InParanoidi Q9W6E3.
    KOi K02842.
    OMAi QSWQNVC.
    OrthoDBi EOG7M3J01.
    TreeFami TF317907.

    Miscellaneous databases

    NextBioi 20806788.
    PROi Q9W6E3.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of zebrafish frizzled genes."
      Furutani-Seiki M.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: WholeImported.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescueImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    5. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiQ9W6E3_DANRE
    AccessioniPrimary (citable) accession number: Q9W6E3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3