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Protein
Submitted name:

Frizzled homolog 10

Gene

fzd10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GO_Central
  • Wnt-activated receptor activity Source: ZFIN
  • Wnt-protein binding Source: GO_Central

GO - Biological processi

  • canonical Wnt signaling pathway Source: GO_Central
  • epiboly Source: ZFIN
  • multicellular organism development Source: UniProtKB-KW
  • non-canonical Wnt signaling pathway Source: GO_Central
  • Wnt signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotation, ReceptorSAAS annotation

Keywords - Biological processi

Wnt signaling pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Frizzled homolog 10Imported
Submitted name:
Frizzled proteinImported
Submitted name:
Fzd10 proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:fzd10Imported
Synonyms:fz4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-990415-220. fzd10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei228 – 25124HelicalSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33626HelicalSequence analysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Transmembranei396 – 42328HelicalSequence analysisAdd
BLAST
Transmembranei444 – 46522HelicalSequence analysisAdd
BLAST
Transmembranei502 – 52221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 580559Sequence analysisPRO_5007719003Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089291.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 151122FZ (frizzled)InterPro annotationAdd
BLAST
Domaini227 – 529303G_PROTEIN_RECEP_F2_4InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation
Contains FZ (frizzled) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOVERGENiHBG006977.
KOiK02842.
OMAiEYGCHGH.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W6E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAAGVGLSL GLLCFAGFCS AISSIDPDRP GEGRCQEIAI PLCKDIGYNL
60 70 80 90 100
TVMPNLMGHE DQNEAAIKLH EFAPLIEFGC HSHLKFFLCS LYAPMCTEQV
110 120 130 140 150
STPIPACRVM CEQARQKCSP IMEQFNFHWP ESLDCSRLPN KNDPNYLCME
160 170 180 190 200
APNNGTDEPP KGSHTQSPDS RPPRPGNSQE LPIKERVGKT TCSNPGKFHY
210 220 230 240 250
VQKSESCAPK CYSNVDVYWS QGDKRFSMVW IAIWSILCFI SSAFTVLTFL
260 270 280 290 300
IDPQRFKYPE RPIIFLSMSY CVYSVGFLVR LFVGVENVAC DRDTGVQYII
310 320 330 340 350
QEGLESTGCT IVFLILYYFG MASSLWWVIL TLTWFLAAGK KWGHEAIEAN
360 370 380 390 400
SSYFHLAAWA IPAIKTIMIL VMRKVAGDEL TGVCYVGSMD VKALTGFVLI
410 420 430 440 450
PLSCYLIIGT SFLLSGFVAL FHIRKVMKTE GENTDKLEKL MVRIGVFSVL
460 470 480 490 500
YTVPATCVIA CYFYERLNMD YWKILAGEQK CADDGKSGEE CVMKSSIPAV
510 520 530 540 550
EIFMVKIFML LVVGITSGMW IWTSKTLQSW QNVFSRKLKK KTRRKAACVF
560 570 580
TGSGPYLKPH PALKGHKTKY EPAGPPATCV
Length:580
Mass (Da):64,857
Last modified:November 1, 1999 - v1
Checksum:i8615F3555830B11C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450819 Genomic DNA. No translation available.
AF117388 mRNA. Translation: AAD25358.1.
BC076546 mRNA. Translation: AAH76546.1.
BC165721 mRNA. Translation: AAI65721.1.
RefSeqiNP_570992.2. NM_130917.2.
UniGeneiDr.80513.

Genome annotation databases

EnsembliENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
GeneIDi30366.
KEGGidre:30366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR450819 Genomic DNA. No translation available.
AF117388 mRNA. Translation: AAD25358.1.
BC076546 mRNA. Translation: AAH76546.1.
BC165721 mRNA. Translation: AAI65721.1.
RefSeqiNP_570992.2. NM_130917.2.
UniGeneiDr.80513.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089291.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000098520; ENSDARP00000089291; ENSDARG00000068213.
GeneIDi30366.
KEGGidre:30366.

Organism-specific databases

CTDi11211.
ZFINiZDB-GENE-990415-220. fzd10.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOVERGENiHBG006977.
KOiK02842.
OMAiEYGCHGH.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of zebrafish frizzled genes."
    Furutani-Seiki M.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: WholeImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  5. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ9W6E3_DANRE
AccessioniPrimary (citable) accession number: Q9W6E3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.