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Protein

Homeobox protein BarH-like 1

Gene

BARX1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor, which is involved in craniofacial development, in odontogenic region definition, and in stomach organogenesis. Binds to a regulatory module of the NCAM promoter.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi95 – 15460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 1
Gene namesi
Name:BARX1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 207›207Homeobox protein BarH-like 1PRO_0000048836Add
BLAST

Expressioni

Tissue specificityi

Expressed predominantly in the facial primordia, developing stomach, and proximal limbs.

Developmental stagei

First detectable in the facial primordia at stage 18 after neural crest migration. Expressed in regions derived from both mid- and hindbrain neural crest. Also expressed in the developing cartilage elements of the limb, first within a restricted population in the prechondrogenic mesenchyme and later in the rounded chondrocytes at the epiphyses of developing long bones.

Structurei

3D structure databases

ProteinModelPortaliQ9W6D8.
SMRiQ9W6D8. Positions 87-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG050665.
InParanoidiQ9W6D8.
PhylomeDBiQ9W6D8.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9W6D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ANERPPGSCS SSGCRRCCRP GPYHSHLAVL KAEQAAVFKF PLAPLGCSGL
60 70 80 90 100
GSALLAAGPG MPGPAGASHL PLELQLRGKL EAAGSGEPGS KAKKGRRSRT
110 120 130 140 150
VFTELQLMGL EKRFEKQKYL STPDRIDLAE SLGLSQLQVK TWYQNRRMKW
160 170 180 190 200
KKIVLQGGGL ESPTKPKGRP KKNSIPSSEQ LSEQERAKET EKPPESPGEP

SERQQEE
Length:207
Mass (Da):22,468
Last modified:November 1, 1999 - v1
Checksum:i3EDE64A91D3BCE84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116460 mRNA. Translation: AAD21043.1.
UniGeneiGga.44.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116460 mRNA. Translation: AAD21043.1.
UniGeneiGga.44.

3D structure databases

ProteinModelPortaliQ9W6D8.
SMRiQ9W6D8. Positions 87-152.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG050665.
InParanoidiQ9W6D8.
PhylomeDBiQ9W6D8.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of chick Barx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordia."
    Barlow A.J., Bogardi J.P., Ladher R., Francis-West P.H.
    Dev. Dyn. 214:291-302(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: FUNCTION.

Entry informationi

Entry nameiBARX1_CHICK
AccessioniPrimary (citable) accession number: Q9W6D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.