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Protein

Homeobox protein BarH-like 1

Gene

BARX1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor, which is involved in craniofacial development, in odontogenic region definition, and in stomach organogenesis. Binds to a regulatory module of the NCAM promoter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi95 – 154HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 1
Gene namesi
Name:BARX1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000048836‹1 – 207Homeobox protein BarH-like 1Add BLAST›207

Expressioni

Tissue specificityi

Expressed predominantly in the facial primordia, developing stomach, and proximal limbs.

Developmental stagei

First detectable in the facial primordia at stage 18 after neural crest migration. Expressed in regions derived from both mid- and hindbrain neural crest. Also expressed in the developing cartilage elements of the limb, first within a restricted population in the prechondrogenic mesenchyme and later in the rounded chondrocytes at the epiphyses of developing long bones.

Structurei

3D structure databases

ProteinModelPortaliQ9W6D8
SMRiQ9W6D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG050665
InParanoidiQ9W6D8
PhylomeDBiQ9W6D8

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9W6D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ANERPPGSCS SSGCRRCCRP GPYHSHLAVL KAEQAAVFKF PLAPLGCSGL
60 70 80 90 100
GSALLAAGPG MPGPAGASHL PLELQLRGKL EAAGSGEPGS KAKKGRRSRT
110 120 130 140 150
VFTELQLMGL EKRFEKQKYL STPDRIDLAE SLGLSQLQVK TWYQNRRMKW
160 170 180 190 200
KKIVLQGGGL ESPTKPKGRP KKNSIPSSEQ LSEQERAKET EKPPESPGEP

SERQQEE
Length:207
Mass (Da):22,468
Last modified:November 1, 1999 - v1
Checksum:i3EDE64A91D3BCE84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116460 mRNA Translation: AAD21043.1
UniGeneiGga.44

Similar proteinsi

Entry informationi

Entry nameiBARX1_CHICK
AccessioniPrimary (citable) accession number: Q9W6D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health