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Q9W689 (ATX3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ataxin-3

EC=3.4.19.12
Alternative name(s):
Machado-Joseph disease protein 1 homolog
Gene names
Name:ATXN3
Synonyms:MDJ1, MJD
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Tissue specificity

Widely expressed.

Sequence similarities

Contains 1 Josephin domain.

Contains 3 UIM (ubiquitin-interacting motif) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Ataxin-3
PRO_0000053834

Regions

Domain1 – 180180Josephin
Repeat227 – 24620UIM 1
Repeat247 – 26620UIM 2
Repeat337 – 35620UIM 3
Compositional bias294 – 2974Poly-Arg
Compositional bias304 – 3118Poly-Gln

Sites

Active site141Nucleophile By similarity
Active site1191Proton acceptor By similarity
Active site1341 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9W689 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 15C81537096DE8C4

FASTA36341,608
        10         20         30         40         50         60 
MESIFHERQE GSLCAQHCLN NLLQGEYFSP VELSSIAQQL DEEERMRMAE GGVSSEEYRT 

        70         80         90        100        110        120 
FLQQPSVNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLGIDPINEK SFICNYKEHW 

       130        140        150        160        170        180 
FTVRKLGKQW FNLNSLLMGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM 

       190        200        210        220        230        240 
IRVQQVQRPK LIGEETAQSR DQRLPRSDVD QAIEVSHPFD GTGMLDEDEE NFQRALALSR 

       250        260        270        280        290        300 
QEIDMEDEEA DLRRAIQLSM QGSRQSEFSN SLPQNASQPP HTSQTDSLSS EDLRRRRQAY 

       310        320        330        340        350        360 
FEKQQQQLQQ QDLTLNLHDK PTINSSTLEA DPGGDMSEED MLQAAMNMSL ESARNHLSTE 


EKK 

« Hide

References

[1]"Conserved domains and lack of evidence for polyglutamine length polymorphism in the chicken homolog of the Machado-Joseph disease gene product ataxin-3."
Linhartova I., Repitz M., Draber P., Nemec M., Wiche G., Propst F.
Biochim. Biophys. Acta 1444:299-305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: SPAFAS.
[2]"Structural modeling of ataxin-3 reveals distant homology to adaptins."
Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF085247 mRNA. Translation: AAD21923.1.
RefSeqNP_989688.1. NM_204357.1.
UniGeneGga.44490.

3D structure databases

ProteinModelPortalQ9W689.
SMRQ9W689. Positions 1-185.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC86.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000017509; ENSGALP00000017488; ENSGALG00000010766.
GeneID378424.
KEGGgga:378424.

Organism-specific databases

CTD4287.

Phylogenomic databases

eggNOGNOG327234.
GeneTreeENSGT00390000001830.
HOGENOMHOG000006034.
HOVERGENHBG025648.
InParanoidQ9W689.
KOK11863.
OMALQAAMNM.
OrthoDBEOG779NZ3.
PhylomeDBQ9W689.
TreeFamTF314228.

Family and domain databases

InterProIPR006155. Josephin.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamPF02099. Josephin. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
PRINTSPR01233. JOSEPHIN.
SMARTSM00726. UIM. 3 hits.
[Graphical view]
PROSITEPS50957. JOSEPHIN. 1 hit.
PS50330. UIM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813765.
PROQ9W689.

Entry information

Entry nameATX3_CHICK
AccessionPrimary (citable) accession number: Q9W689
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families