Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ataxin-3

Gene

ATXN3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14NucleophilePROSITE-ProRule annotation1
Active sitei119Proton acceptorPROSITE-ProRule annotation1
Active sitei134PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-GGA-5689877. Josephin domain DUBs.

Protein family/group databases

MEROPSiC86.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-3 (EC:3.4.19.12)
Alternative name(s):
Machado-Joseph disease protein 1 homolog
Gene namesi
Name:ATXN3
Synonyms:MDJ1, MJD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538341 – 363Ataxin-3Add BLAST363

Proteomic databases

PaxDbiQ9W689.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSGALG00000010766.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017488.

Structurei

3D structure databases

ProteinModelPortaliQ9W689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 180JosephinPROSITE-ProRule annotationAdd BLAST180
Domaini227 – 246UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini247 – 266UIM 2PROSITE-ProRule annotationAdd BLAST20
Domaini337 – 356UIM 3PROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi294 – 297Poly-Arg4
Compositional biasi304 – 311Poly-Gln8

Sequence similaritiesi

Contains 1 Josephin domain.PROSITE-ProRule annotation
Contains 3 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2935. Eukaryota.
ENOG4111G4B. LUCA.
GeneTreeiENSGT00390000001830.
HOGENOMiHOG000006034.
HOVERGENiHBG025648.
InParanoidiQ9W689.
KOiK11863.
OMAiMLQAAMN.
OrthoDBiEOG091G0OC6.
PhylomeDBiQ9W689.
TreeFamiTF314228.

Family and domain databases

InterProiIPR033865. Ataxin-3.
IPR006155. Josephin.
IPR003903. UIM_dom.
[Graphical view]
PANTHERiPTHR14159. PTHR14159. 1 hit.
PfamiPF02099. Josephin. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM01246. Josephin. 1 hit.
SM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
PS50330. UIM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESIFHERQE GSLCAQHCLN NLLQGEYFSP VELSSIAQQL DEEERMRMAE
60 70 80 90 100
GGVSSEEYRT FLQQPSVNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ
110 120 130 140 150
RLGIDPINEK SFICNYKEHW FTVRKLGKQW FNLNSLLMGP ELISDTYLAL
160 170 180 190 200
FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQVQRPK LIGEETAQSR
210 220 230 240 250
DQRLPRSDVD QAIEVSHPFD GTGMLDEDEE NFQRALALSR QEIDMEDEEA
260 270 280 290 300
DLRRAIQLSM QGSRQSEFSN SLPQNASQPP HTSQTDSLSS EDLRRRRQAY
310 320 330 340 350
FEKQQQQLQQ QDLTLNLHDK PTINSSTLEA DPGGDMSEED MLQAAMNMSL
360
ESARNHLSTE EKK
Length:363
Mass (Da):41,608
Last modified:November 1, 1999 - v1
Checksum:i15C81537096DE8C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085247 mRNA. Translation: AAD21923.1.
RefSeqiNP_989688.1. NM_204357.1.
UniGeneiGga.44490.

Genome annotation databases

EnsembliENSGALT00000017509; ENSGALP00000017488; ENSGALG00000010766.
GeneIDi378424.
KEGGigga:378424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085247 mRNA. Translation: AAD21923.1.
RefSeqiNP_989688.1. NM_204357.1.
UniGeneiGga.44490.

3D structure databases

ProteinModelPortaliQ9W689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017488.

Protein family/group databases

MEROPSiC86.001.

Proteomic databases

PaxDbiQ9W689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000017509; ENSGALP00000017488; ENSGALG00000010766.
GeneIDi378424.
KEGGigga:378424.

Organism-specific databases

CTDi4287.

Phylogenomic databases

eggNOGiKOG2935. Eukaryota.
ENOG4111G4B. LUCA.
GeneTreeiENSGT00390000001830.
HOGENOMiHOG000006034.
HOVERGENiHBG025648.
InParanoidiQ9W689.
KOiK11863.
OMAiMLQAAMN.
OrthoDBiEOG091G0OC6.
PhylomeDBiQ9W689.
TreeFamiTF314228.

Enzyme and pathway databases

ReactomeiR-GGA-5689877. Josephin domain DUBs.

Miscellaneous databases

PROiQ9W689.

Gene expression databases

BgeeiENSGALG00000010766.

Family and domain databases

InterProiIPR033865. Ataxin-3.
IPR006155. Josephin.
IPR003903. UIM_dom.
[Graphical view]
PANTHERiPTHR14159. PTHR14159. 1 hit.
PfamiPF02099. Josephin. 1 hit.
PF02809. UIM. 3 hits.
[Graphical view]
SMARTiSM01246. Josephin. 1 hit.
SM00726. UIM. 3 hits.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
PS50330. UIM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATX3_CHICK
AccessioniPrimary (citable) accession number: Q9W689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.