Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9W683

- CP1A1_LIZSA

UniProt

Q9W683 - CP1A1_LIZSA

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Liza saliens (Leaping mullet)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiLiza saliens (Leaping mullet)
    Taxonomic identifieri48192 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaMugilomorphaeMugilidaeLiza

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051639Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9W683-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALMILPFIG ALSVSESLVA VVTVCLVYLI IKSFQDKIPE GLSRLPGPKP    50
    LPIIGNVLEV GSRPYLSLTE MGKRYGNVFQ IQIGMRPVVV LSGNETVRQA 100
    LIKQGDEFAG RPDLYSFRFI SEGKSLAFST DQAGVWRARR KLAYSALRSF 150
    STLEGTTPEY SCVLEEHISK EAKYLIQQLD TVMKADGSFD PFRYIVVSVA 200
    NVICGMCFGR RYDHHDQELL SLVNLSDEFG QVVGSGNPAD FIPILQYLPN 250
    KTMKKFVSIN DRFISFVQKI VSEHYATFNK DNIRDITDSL IDHCEDRKLD 300
    ENANVQMSDE KVVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQEXLYQ 350
    ELKENVGLDR TPVLSDRNNL PLLESFILEI FRHSSFLPFT IPHCTTKDTS 400
    LNGYYIPKDT CVFINQWQIN HDPELWKEPS SFNPDRFLSA DGTEVNKVDG 450
    EKVMIFGMGK RRCIGEVIAR NEVYLFLAIL IQKLHFCNLP GEPLDMTPEY 500
    GLTMKHKRCQ LRATARVRSD H 521
    Length:521
    Mass (Da):58,944
    Last modified:November 1, 1999 - v1
    Checksum:i1C5DBF224A73C6A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072899 mRNA. Translation: AAD22398.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072899 mRNA. Translation: AAD22398.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of mullet (Liza saliens) liver cytochrome P450 1A1."
      Sen A., Buhler D.R., Wang-Buhler J.-L.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_LIZSA
    AccessioniPrimary (citable) accession number: Q9W683
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3