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Q9W683 (CP1A1_LIZSA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Gene names
Name:cyp1a1
OrganismLiza saliens (Leaping mullet)
Taxonomic identifier48192 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaMugilomorphaeMugilidaeLiza

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Cytochrome P450 1A1
PRO_0000051639

Sites

Metal binding4631Iron (heme axial ligand) By similarity
Binding site2291Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9W683 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 1C5DBF224A73C6A0

FASTA52158,944
        10         20         30         40         50         60 
MALMILPFIG ALSVSESLVA VVTVCLVYLI IKSFQDKIPE GLSRLPGPKP LPIIGNVLEV 

        70         80         90        100        110        120 
GSRPYLSLTE MGKRYGNVFQ IQIGMRPVVV LSGNETVRQA LIKQGDEFAG RPDLYSFRFI 

       130        140        150        160        170        180 
SEGKSLAFST DQAGVWRARR KLAYSALRSF STLEGTTPEY SCVLEEHISK EAKYLIQQLD 

       190        200        210        220        230        240 
TVMKADGSFD PFRYIVVSVA NVICGMCFGR RYDHHDQELL SLVNLSDEFG QVVGSGNPAD 

       250        260        270        280        290        300 
FIPILQYLPN KTMKKFVSIN DRFISFVQKI VSEHYATFNK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENANVQMSDE KVVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQEXLYQ ELKENVGLDR 

       370        380        390        400        410        420 
TPVLSDRNNL PLLESFILEI FRHSSFLPFT IPHCTTKDTS LNGYYIPKDT CVFINQWQIN 

       430        440        450        460        470        480 
HDPELWKEPS SFNPDRFLSA DGTEVNKVDG EKVMIFGMGK RRCIGEVIAR NEVYLFLAIL 

       490        500        510        520 
IQKLHFCNLP GEPLDMTPEY GLTMKHKRCQ LRATARVRSD H 

« Hide

References

[1]"Cloning and sequencing of mullet (Liza saliens) liver cytochrome P450 1A1."
Sen A., Buhler D.R., Wang-Buhler J.-L.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF072899 mRNA. Translation: AAD22398.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_LIZSA
AccessionPrimary (citable) accession number: Q9W683
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families