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Protein

Mothers against decapentaplegic homolog

Gene

smad4.1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homologUniRule annotation
Short name:
MAD homologUniRule annotation
Short name:
Mothers against DPP homologUniRule annotation
Alternative name(s):
SMAD family memberUniRule annotation
Gene namesi
Name:smad4.1Imported
Synonyms:MGC79910Imported, XSmad4aImported, xsmad4aImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865543. smad4.1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

IntActiQ9W639. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9W639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 139MH1InterPro annotationAdd BLAST125
Domaini320 – 549MH2InterPro annotationAdd BLAST230

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 61Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOVERGENiHBG053353.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiView protein in InterPro
IPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD-like_dom_sf.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_dom_sf.
IPR036578. SMAD_MH1_sf.
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiView protein in Pfam
PF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
SMARTiView protein in SMART
SM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiView protein in PROSITE
PS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9W639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITNTPTSN DACLSIVHSL MCHRQGGESE TFAKRAIESL VKKLKEKKDE
60 70 80 90 100
LDSLITAITT NGAHPSKCVT IQRTLDGRLQ VAGRKGFPHV IYARLWRWPD
110 120 130 140 150
LHKNELKHVK YCQYAFDLKC DSVCVNPYHY ERVVSPGIDL SGLTLQSSAP
160 170 180 190 200
SGLLVKDEYG HDYAEGQQSI SAGDGLSIQT IQHPPSSRSS TETYSNPALL
210 220 230 240 250
VPSEPSTPNP TSFSSIPVPS TSQPASLLAA THNDGLLSIA PVPPQGTQNG
260 270 280 290 300
FSAQPATYHH NSTTTWTGSR TAAYTPNMSH HPNGHLQHHP PMPHPGHYWP
310 320 330 340 350
VHNELAFQPP ISNHPAPDYW CSIAYFEMDV QVGETFKVPS SCPIVTVDGY
360 370 380 390 400
VDPSGGDRFC LGQLSNVHRT EAIERARLHI GKGVQLECKG EGDVWVRCLS
410 420 430 440 450
DHAVFVQSYY LDREAGRAPG DAVHKIYPSA YIKVFDLRQC HRQMQQQAAT
460 470 480 490 500
AQAAAAAQAA AVAGNIPGPG SVGGIAPAIS LSAAAGIGVD DLRRLCILRM
510 520 530 540
SFVKGWGPDY PRQSIKETPC WIEIHLHRAL QLLDEVLHTM PIADPQPLD
Length:549
Mass (Da):59,856
Last modified:November 1, 1999 - v1
Checksum:i72431FD6AC674150
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084196 mRNA. Translation: AAH84196.1.
BC169681 mRNA. Translation: AAI69681.1.
AB022721 mRNA. Translation: BAA77514.1.
RefSeqiNP_001090261.1. NM_001096792.1.
NP_001090536.1. NM_001097067.1.
UniGeneiXl.60482.
Xl.885.

Genome annotation databases

GeneIDi779167.
780764.

Similar proteinsi

Entry informationi

Entry nameiQ9W639_XENLA
AccessioniPrimary (citable) accession number: Q9W639
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)