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Protein

Probable chitinase 3

Gene

Cht3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1087Proton donorPROSITE-ProRule annotation1
Active sitei1531Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

  • chitinase activity Source: UniProtKB
  • chitin binding Source: GO_Central

GO - Biological processi

  • chitin catabolic process Source: UniProtKB
  • polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Keywords - Ligandi

Chitin-binding

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.
GH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chitinase 3 (EC:3.2.1.14)
Alternative name(s):
Probable chitinase 1
Gene namesi
Name:Cht3
Synonyms:Cht1
ORF Names:CG18140
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0250907. Cht3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000007705121 – 2286Probable chitinase 3Add BLAST2266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi721 ↔ 734PROSITE-ProRule annotation
Disulfide bondi827 ↔ 840PROSITE-ProRule annotation
Disulfide bondi897 ↔ 910PROSITE-ProRule annotation
Disulfide bondi1857 ↔ 1868PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9W5U2.
PRIDEiQ9W5U2.

Expressioni

Gene expression databases

BgeeiFBgn0250907.
ExpressionAtlasiQ9W5U2. baseline.
GenevisibleiQ9W5U2. DM.

Interactioni

Protein-protein interaction databases

BioGridi78241. 2 interactors.
DIPiDIP-19404N.
MINTiMINT-815820.
STRINGi7227.FBpp0110419.

Structurei

3D structure databases

ProteinModelPortaliQ9W5U2.
SMRiQ9W5U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini689 – 744Chitin-binding type-2 1PROSITE-ProRule annotationAdd BLAST56
Domaini797 – 850Chitin-binding type-2 2PROSITE-ProRule annotationAdd BLAST54
Domaini866 – 920Chitin-binding type-2 3PROSITE-ProRule annotationAdd BLAST55
Domaini1826 – 1878Chitin-binding type-2 4PROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 4 chitin-binding type-2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
InParanoidiQ9W5U2.
KOiK01183.
OMAiAVMTYDY.
OrthoDBiEOG091G014W.
PhylomeDBiQ9W5U2.

Family and domain databases

Gene3Di2.170.140.10. 4 hits.
3.10.50.10. 4 hits.
3.20.20.80. 8 hits.
InterProiIPR002557. Chitin-bd_dom.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01607. CBM_14. 4 hits.
PF00704. Glyco_hydro_18. 4 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 4 hits.
SM00636. Glyco_18. 4 hits.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 8 hits.
SSF54556. SSF54556. 4 hits.
SSF57625. SSF57625. 4 hits.
PROSITEiPS50940. CHIT_BIND_II. 4 hits.
PS01095. CHITINASE_18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W5U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPYVPSVLV VVVLAISVKA HIRVDKLQIH SESNYKPAFI RSAVESIPLD
60 70 80 90 100
IDAILLLRNS TKPEFGDAFL PLRSAVESIP KLYQSNTSRF RKNPDVRSFV
110 120 130 140 150
RDSVESLPND EDGLEHIEIF TKYYNSVSDV AGVDLKSKKL THVNLDPGTI
160 170 180 190 200
SDKYAAFIAR GNSEDYYPKS YRAGSPHQEL LKMMNIEHTD KLDRYSDLQH
210 220 230 240 250
QQSYGALGLA NRNDLKMTKK VLCYMSNWAF YRSGEAHFVP EQIDPNLCSA
260 270 280 290 300
IIYSFASLDP DHLTIREFDS WVDLDNQYYR RVTSLGVPVL IALGGWTDSS
310 320 330 340 350
GSKYSRLVSD NLKRRVFISS VSSFLLRHGF SGLHLDWNYP KCWQSDCSRG
360 370 380 390 400
PVTDRPNLTK LLRELRTEFQ SVDPKFQLGV AISGYKEIIK EAYDFPALSD
410 420 430 440 450
IVDYMTVMTY DYHGAWEQKT GHVSPLYGLS SDTYPQYNTN YTMQLLLKMG
460 470 480 490 500
ARREKLVLSI PFYGQSFTLA TAHQILAGPG VAASGPGDAG ELTKQPGMLA
510 520 530 540 550
YYEICQRLTK FNWISDRNLN VIFGPFAMLN DQWVGYEDPT SAQAKARYAA
560 570 580 590 600
NNNFAGVAAW TIDLDDFRNL CCNESYPLLR AINRALGRLD SEPPTQPNCK
610 620 630 640 650
RPTLLATPVP PQMTTISSDG SGGLGQNHDH TTSLPSGQIS SSPVSTTITS
660 670 680 690 700
TFPWWSSTTK RPREPTKTTA QPTHTTILIP AGINPVVQPS NCKSGEFFAD
710 720 730 740 750
SNNCNAYYHC FFAGELQQQF CPSGLHWNNE AKGCDWPSSA QCSLKLDQHL
760 770 780 790 800
STSYPNPIQT SKKPETTLKP NKKPSEISTH HQVNSTSSRP QYMRPTILEC
810 820 830 840 850
TEGDYYPHRN CRKYYICVNK ALVPSECGGD LHWDGIKKLC DWPENVQCVT
860 870 880 890 900
SKKYLKIIKS SSANEEDPCK GEKRVPYPGN CSKYLFCLWN RLQASDCPPG
910 920 930 940 950
LHYNERIGNC DWPAAAKCNP KGSESSEEAE LNAMPKPPTP QTPSSHLRPT
960 970 980 990 1000
YPTEKPVPKP RDSHYKVICY FTNWAWYRKG IGRFTPDDIN TELCTHVIYG
1010 1020 1030 1040 1050
FAVLDYSELV LRTHDSWADV ENNFYTRVTS LKSKGIKVSL ALGGWNDSQG
1060 1070 1080 1090 1100
DKYSRLVRSP MARSRFVRHA LEFIEKYGFE GLDLDWEYPV CWQTECNKGS
1110 1120 1130 1140 1150
TEEKDGFTAW VQELSEAFRP RGLMLSTAVS PSRKIIDAGY DIPQLSRYFD
1160 1170 1180 1190 1200
WIAVMTYDFH GHWDKKTGHV APLYHHPDDD FEYFNVNYSI NYWMEKGAPS
1210 1220 1230 1240 1250
QKLVMGIPLY GQSFTLENTN SSGLNAKAPA PGEAGEFTRA AGFLAYYEIC
1260 1270 1280 1290 1300
ERVNRQGWQV VHDEFGRMGP YAYKGTQWVS YDSPDMVRKK SLLVRSLKLG
1310 1320 1330 1340 1350
GGMVWALDLD DFKNRCGNGV HPLLTEIHNV LKDPPSLMEI PGPIETTPTE
1360 1370 1380 1390 1400
YPGMEEEIHE SNGEGPEVQP IEAVMQTCEN EGEEHEGILD PNHVLEEENI
1410 1420 1430 1440 1450
EATEMATEFK IICYFTNWAW YRQGGGKFLP EDIDSDLCTH IIYGFAVLSR
1460 1470 1480 1490 1500
DNLTIQPHDS WADLDNKFYE RIVAYRKKGA KVTVAIGGWN DSAGDKYSRL
1510 1520 1530 1540 1550
VRNPEARSRF IRNVLDFIEE YNFDGLDLDW EYPVCWQVDC KKGTAEEKIG
1560 1570 1580 1590 1600
FSALVRELFY AFQPRGLILS AAVSPNKKVI DAGYEVAELS HYFSWISVMA
1610 1620 1630 1640 1650
YDYHGQWDKK TGHVAPMYSH PEGTANFNAN FSMNYWISMG ADRRKLVMGI
1660 1670 1680 1690 1700
PLYGQSFSLA ETTKHQLNAP TYGGGEAGEA TRARGFLAYY EICLKIRHHR
1710 1720 1730 1740 1750
WNVVRDTKGR IGPFAYHGDQ WVSFDDVPMI RHKSEYIKAM GLGGAMIWAL
1760 1770 1780 1790 1800
DLDDFKNVCE CESYPLLKAI NRVLRGFGGP QPKCLLENPK STMKPNIKPP
1810 1820 1830 1840 1850
FRPTINAPSG PNLDSPTQNV SLNVLSIKCH SKNYLAHEWD CTKYYICEHG
1860 1870 1880 1890 1900
TYVERSCPLG LQWNKTYCDW PTNVQSSLGS NQRTQEPAVH RPNPTSVITE
1910 1920 1930 1940 1950
PPIINNSYKV VCYFTSWAWY RSSQGKFVPE DIDANLCTHL IYGFAVLDSK
1960 1970 1980 1990 2000
SLTIKTHDSW TDIDNRFYER VVEYKQRGLR VMLAIGGWND SLGSKYARLV
2010 2020 2030 2040 2050
LNSQSRRRFV ASVISFLEQH GFEGLDLAWE FPVCWQVNCN RGNPTEKDGF
2060 2070 2080 2090 2100
VALVKELSEA FKENGLILSA AVSPSKMVID AGYNVFELSP YFDWVAVMTY
2110 2120 2130 2140 2150
DFHGHWDMRT GQIAPLFHRG GDENLYLNGN FSIHYWLERG IPNDKLVMGM
2160 2170 2180 2190 2200
PMYGQTFTLA DQNRRSLNDK TVGPGKAGTF TRADGFLAYY EICEKVVNDD
2210 2220 2230 2240 2250
WKVVRDEEGI FGSYAYSGNQ WISYDDVTTI RRKSQFIKSL QLGGGMIWAL
2260 2270 2280
DLDDFRGLCG CGKHPLLRTL SQELLGIPGQ KAKDCI
Length:2,286
Mass (Da):258,777
Last modified:November 25, 2008 - v2
Checksum:iB4FC42CE4719F12A
GO

Sequence cautioni

The sequence AAM50881 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: EAA46011.1.
BT021372 mRNA. Translation: AAX33520.1.
AF026500 Genomic DNA. Translation: AAB81858.1.
AF026502 Genomic DNA. Translation: AAB81860.1.
AY119021 mRNA. Translation: AAM50881.1. Different initiation.
RefSeqiNP_001036422.1. NM_001042957.2.
NP_001260697.1. NM_001273768.1.
NP_001260698.1. NM_001273769.1.
UniGeneiDm.14448.

Genome annotation databases

EnsemblMetazoaiFBtr0111127; FBpp0110419; FBgn0250907.
FBtr0331165; FBpp0303592; FBgn0250907.
FBtr0331166; FBpp0303593; FBgn0250907.
GeneIDi3355116.
KEGGidme:Dmel_CG18140.
UCSCiCG18140-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: EAA46011.1.
BT021372 mRNA. Translation: AAX33520.1.
AF026500 Genomic DNA. Translation: AAB81858.1.
AF026502 Genomic DNA. Translation: AAB81860.1.
AY119021 mRNA. Translation: AAM50881.1. Different initiation.
RefSeqiNP_001036422.1. NM_001042957.2.
NP_001260697.1. NM_001273768.1.
NP_001260698.1. NM_001273769.1.
UniGeneiDm.14448.

3D structure databases

ProteinModelPortaliQ9W5U2.
SMRiQ9W5U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78241. 2 interactors.
DIPiDIP-19404N.
MINTiMINT-815820.
STRINGi7227.FBpp0110419.

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.
GH18. Glycoside Hydrolase Family 18.

Proteomic databases

PaxDbiQ9W5U2.
PRIDEiQ9W5U2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0111127; FBpp0110419; FBgn0250907.
FBtr0331165; FBpp0303592; FBgn0250907.
FBtr0331166; FBpp0303593; FBgn0250907.
GeneIDi3355116.
KEGGidme:Dmel_CG18140.
UCSCiCG18140-RA. d. melanogaster.

Organism-specific databases

CTDi3355116.
FlyBaseiFBgn0250907. Cht3.

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
InParanoidiQ9W5U2.
KOiK01183.
OMAiAVMTYDY.
OrthoDBiEOG091G014W.
PhylomeDBiQ9W5U2.

Miscellaneous databases

GenomeRNAii3355116.
PROiQ9W5U2.

Gene expression databases

BgeeiFBgn0250907.
ExpressionAtlasiQ9W5U2. baseline.
GenevisibleiQ9W5U2. DM.

Family and domain databases

Gene3Di2.170.140.10. 4 hits.
3.10.50.10. 4 hits.
3.20.20.80. 8 hits.
InterProiIPR002557. Chitin-bd_dom.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01607. CBM_14. 4 hits.
PF00704. Glyco_hydro_18. 4 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 4 hits.
SM00636. Glyco_18. 4 hits.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 8 hits.
SSF54556. SSF54556. 4 hits.
SSF57625. SSF57625. 4 hits.
PROSITEiPS50940. CHIT_BIND_II. 4 hits.
PS01095. CHITINASE_18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHIT3_DROME
AccessioniPrimary (citable) accession number: Q9W5U2
Secondary accession number(s): O17420
, O17422, Q7PL80, Q8MS85, Q9W5U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.