Q9W5R8 (RL5_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L5

Gene names

Name:	RpL5
Synonyms:	yip6
ORF Names:	CG17489

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein binds 5S RNA By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ribosomal protein L18P family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ribosomal large subunit assembly Inferred from sequence or structural similarity. Source: UniProtKB translation Inferred from electronic annotation. Source: InterPro
Cellular component	cytosolic large ribosomal subunit Non-traceable author statement. Source: FlyBase
Molecular function	5S rRNA binding Non-traceable author statement. Source: FlyBase protein binding Inferred from physical interaction. Source: FlyBase structural constituent of ribosome Non-traceable author statement. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	60S ribosomal protein L5		PRO_0000291559

Sequences

	Sequence		Length	Mass (Da)
	Q9W5R8 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: 523F50ED67E7841A	FASTA	299	34,037
	10 20 30 40 50 60 MGFVKVVKNK QYFKRYQVKF RRRREGKTDY YARKRLTFQD KNKYNTPKYR LIVRLSNKDI 70 80 90 100 110 120 TVQIAYARIE GDRVVCAAYS HELPKYGIQV GLTNYAAAYC TGLLVARRVL NKLGLDSLYA 130 140 150 160 170 180 GCTEVTGEEF NVEPVDDGPG AFRCFLDVGL ARTTTGARVF GAMKGAVDGG LNIPHSVKRF 190 200 210 220 230 240 PGYSAETKSF NADVHRAHIF GQHVADYMRS LEEEDEESFK RQFSRYIKLG IRADDLEDIY 250 260 270 280 290 KKAHQAIRND PTHKVTAKKS SAVTKKRWNA KKLTNEQRKT KIAAHKAAYV AKLQSETEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014134 Genomic DNA. Translation: EAA46016.1. AE014134 Genomic DNA. Translation: EAA46019.1. AY071305 mRNA. Translation: AAL48927.1.
RefSeq	NP_001036387.1. NM_001042922.2. NP_001036388.1. NM_001042923.2.
UniGene	Dm.7121.
3D structure databases
HSSP	HSSP built from PDB template 1S72 based on UniProtKB P14123.
ProteinModelPortal	Q9W5R8.
SMR	Q9W5R8. Positions 2-282.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-17125N.
IntAct	Q9W5R8. 3 interactions.
MINT	MINT-915617.
STRING	Q9W5R8.
Proteomic databases
PRIDE	Q9W5R8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0111129; FBpp0110421; FBgn0064225. FBtr0111132; FBpp0110424; FBgn0064225.
GeneID	3355124.
KEGG	dme:Dmel_CG17489.
Organism-specific databases
CTD	6125.
FlyBase	FBgn0064225. RpL5.
Phylogenomic databases
GeneTree	EMGT00050000015975.
InParanoid	Q9W5R8.
OMA	YNAEAHR.
OrthoDB	EOG4CJSZT.
PhylomeDB	Q9W5R8.
Gene expression databases
Bgee	Q9W5R8.
Family and domain databases
InterPro	IPR005484. Ribosomal_L18/L5. IPR005485. Ribosomal_L5_euk/arc. [Graphical view]
KO	K02932.
PANTHER	PTHR23410. Ribosomal_L5euk. 1 hit.
Pfam	PF00861. Ribosomal_L18p. 1 hit. [Graphical view]
PRINTS	PR00058. RIBOSOMALL5.
ProtoNet	Search...
Other
NextBio	850701.

Entry information

Entry name

RL5_DROME

Accession

Primary (citable) accession number: Q9W5R8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project