Q9W596 (FUTSC_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated protein futsch

Gene names

Name:	futsch
ORF Names:	CG34387

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	5495 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by Fmr1. Ref.1 Ref.5 Ref.6
Subunit structure	Interacts with Fmr1. Ref.6
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton. Note: Microtubule-associated. Ref.1 Ref.5
Tissue specificity	Neuronal cells within the PNS and CNS. Ref.1 Ref.5
Developmental stage	All stages. Ref.1
Miscellaneous	'Futsch' means 'gone' in German. Ref.1
Sequence caution	The sequence CAA20006.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Repeat
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	axon cargo transport Inferred from mutant phenotype. Source: FlyBase axonogenesis Inferred from mutant phenotype Ref.1. Source: FlyBase compound eye development Non-traceable author statement. Source: FlyBase dendrite morphogenesis Inferred from mutant phenotype Ref.1. Source: FlyBase microtubule cytoskeleton organization Inferred from mutant phenotype Ref.5. Source: FlyBase negative regulation of neuron apoptosis Inferred from mutant phenotype. Source: FlyBase neurofilament cytoskeleton organization Inferred from mutant phenotype. Source: FlyBase neuromuscular junction development Non-traceable author statement. Source: FlyBase olfactory learning Inferred from mutant phenotype. Source: FlyBase regulation of synaptic growth at neuromuscular junction Inferred from mutant phenotype Ref.5. Source: FlyBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from direct assay Ref.5. Source: UniProtKB
Molecular function	kinase binding Inferred from physical interaction. Source: BHF-UCL microtubule binding Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 5495	5495	Microtubule-associated protein futsch		PRO_0000087388
Regions
	Repeat	1469 – 1502	34	1
	Repeat	1513 – 1539	27	2
	Repeat	1622 – 1649	28	3
	Repeat	1660 – 1686	27	4
	Repeat	1690 – 1718	29	5
	Repeat	1755 – 1782	28	6
	Repeat	1790 – 1818	29	7
	Repeat	1837 – 1865	29	8
	Repeat	1874 – 1902	29	9
	Repeat	1911 – 1939	29	10
	Repeat	1948 – 1976	29	11
	Repeat	1985 – 2013	29	12
	Repeat	2022 – 2050	29	13
	Repeat	2059 – 2087	29	14
	Repeat	2096 – 2124	29	15
	Repeat	2133 – 2161	29	16
	Repeat	2170 – 2198	29	17
	Repeat	2215 – 2243	29	18
	Repeat	2262 – 2292	31	19
	Repeat	2355 – 2391	37	20
	Repeat	2703 – 2726	24	21
	Repeat	2761 – 2787	27	22
	Repeat	2820 – 2846	27	23
	Repeat	2864 – 2892	29	24
	Repeat	2907 – 2933	27	25
	Repeat	2956 – 2987	32	26
	Repeat	3006 – 3034	29	27
	Repeat	3049 – 3075	27	28
	Repeat	3089 – 3117	29	29
	Repeat	3131 – 3158	28	30
	Repeat	3200 – 3224	25	31
	Repeat	3228 – 3256	29	32
	Repeat	3265 – 3293	29	33
	Repeat	3302 – 3330	29	34
	Repeat	3339 – 3367	29	35
	Repeat	3376 – 3404	29	36
	Repeat	3413 – 3441	29	37
	Repeat	3450 – 3478	29	38
	Repeat	3487 – 3515	29	39
	Repeat	3524 – 3552	29	40
	Repeat	3561 – 3589	29	41
	Repeat	3598 – 3626	29	42
	Repeat	3635 – 3663	29	43
	Repeat	3672 – 3700	29	44
	Repeat	3709 – 3737	29	45
	Repeat	3746 – 3774	29	46
	Repeat	3783 – 3811	29	47
	Repeat	3820 – 3848	29	48
	Repeat	3867 – 3894	28	49
	Repeat	3895 – 3921	27	50
	Repeat	3931 – 3958	28	51
	Repeat	3968 – 3995	28	52
	Repeat	4005 – 4032	28	53
	Region	1469 – 4032	2564	53 X approximate repeat
Amino acid modifications
	Modified residue	3067	1	Phosphoserine Ref.7
	Modified residue	3071	1	Phosphoserine Ref.7
	Modified residue	3075	1	Phosphoserine Ref.7
Experimental info
	Sequence conflict	647 – 648	2	Missing in CAA20006. Ref.4
	Sequence conflict	732	1	A → T in CAA20006. Ref.4
	Sequence conflict	799	1	T → A in CAA20006. Ref.4
	Sequence conflict	1322	1	G → N in CAA20006. Ref.4
	Sequence conflict	2312	1	T → S in CAA20006. Ref.4
	Sequence conflict	2887	1	C → S in CAA20006. Ref.4
	Sequence conflict	3080	1	M → V in CAA20006. Ref.4
	Sequence conflict	3557	1	E → K in CAA20006. Ref.4
	Sequence conflict	3571	1	R → S in CAA20006. Ref.4
	Sequence conflict	3620	1	S → Y in CAA20006. Ref.4
	Sequence conflict	3844	1	K → E in CAA20006. Ref.4
	Sequence conflict	3902	1	E → V in CAA20006. Ref.4
	Sequence conflict	4439	1	T → A in CAA20006. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9W596 [UniParc]. Last modified May 5, 2009. Version 4. Checksum: 4CBCB11D44981FB1	FASTA	5,495	592,078
	10 20 30 40 50 60 MGDQPKATTT ATGGAAGPVP EGDAVMATTN QDALAKGAGD GPAQDAAQEP GQAEHGEPGD 70 80 90 100 110 120 GGDGGDDGAT DAGASSLPPS EIGGRAPLDT ACSDADGGAP SSLAGGIVGP PSPLTGCYLL 130 140 150 160 170 180 IVLGEPHSEE HKDNILQHLL KGFLSWDVSD CHVDLEEELN TITQHAPEGE EARHGERLIQ 190 200 210 220 230 240 YASENLVTEV LIHPQYNTLI QCMRNLLSSF TRHRHIIHAG YTFSGNGSWI LQDGTFSVAD 250 260 270 280 290 300 FSEAFQEHDV QRVIRAYADT ITMNIHCADA GLWHTLPEKA FARQCRIRIN PVDVLDTSSE 310 320 330 340 350 360 CINGFIDYLA PMVMPTSLRE LLETSDVVGN IRFTHPTLYV FPGGQGDAAL FGINGFNMLV 370 380 390 400 410 420 DGGFNRKACF WDFARHLDRL DAVLMTRLNN SNVQGLGAVV SRKRDAHVYP QIGHFFGNVP 430 440 450 460 470 480 DRKGLPSPDG DKDRDPLLID LFERGHGIVS DLKALDLKPQ CCYRNQEPVN LYHKVGHGTL 490 500 510 520 530 540 DMYVISPARD SKEVKEFLQK WHAGDQRLFA ARDSRDFNFP LQNLVSICAL LVWQPANPDD 550 560 570 580 590 600 TITRILFPGS TPDFKIQEGL EKLKHLEFMK HSTCTAKSIA PAIQTVTSTR KSLKSAIEAT 610 620 630 640 650 660 PAPPSASYKT TKFSPVASAA LAVQHPQQQD NKAKEAAAAA AAAAAAAASA ATIARAKADS 670 680 690 700 710 720 MDTDAEPEHE ADPEPADTGD EAAPTEQEPE AETEPEPEHE PEAEQDKDVG EEKKVEVLIM 730 740 750 760 770 780 KPQQATPAVI AASGKDGVDA ASADATPTGK LSKASAKGKA DKPRAEVKPV VRSRIDTKPP 790 800 810 820 830 840 KSMDRKLAKR DEKKSSPTTT PAARAPVAQN AKPKVLSRPA TKSSPSSTPA KSAKEANNRK 850 860 870 880 890 900 VLESKQQAAR VQATSTVSRR VTSTASERRV QQQAEAKTAA TGATQATQRK PISRRPRGVS 910 920 930 940 950 960 PSKRAPAPGS PVKQAKPKAA DLKKTRLDKG GTTDSSLVST PSADEATAAK KLQDLTASQE 970 980 990 1000 1010 1020 LDAEKQRELD DLKEEQEVVR EIEAVFSRDE MKRQQHQQIK AELREMPAEG TGDGENEPDE 1030 1040 1050 1060 1070 1080 EEEYLIIEKE EVEQYTEDSI VEQESSMTKE EEIQKHQRDS QESEKKRKKS AEEEIEAAIA 1090 1100 1110 1120 1130 1140 KVEAAERKAR LEGASARQDE SELDVEPEQS KIKAEVQDII ATAKDIAKSR TEEQLAKPAE 1150 1160 1170 1180 1190 1200 EELSSPTPEE KLSKKTSDTK DDQIGAPVDV LPVNLQESLP EEKFSATIES GATTAPTLPE 1210 1220 1230 1240 1250 1260 DERIPLDQIK EDLVIEEKYV KEETKEAEAI VVATVQTLPE AAPLAIDTIL ASATKDAPKD 1270 1280 1290 1300 1310 1320 ANAEALGELP DSGERVLPMK MTFEAQQNLL RDVIKTPDEV ADLPVHEEAD LGLYEKDSQD 1330 1340 1350 1360 1370 1380 AGAKSISHKE ESAKEEKETD DEKENKVGEI ELGDEPNKVD ISHVLLKESV QEVAEKVVVI 1390 1400 1410 1420 1430 1440 ETTVEKKQEE IVEATTVITQ ENQEDLMEQV KDKEEHEQKI ESGIITEKEA KKSASTPEEK 1450 1460 1470 1480 1490 1500 ETSDITSDDE LPAQLADPTT VPPKSAKDRE DTGSIESPPT IEEAIEVEVQ AKQEAQKPVP 1510 1520 1530 1540 1550 1560 APEEAIKTEK SPLASKETSR PESATGSVKE DTEQTKSKKS PVPSRPESEA KDKKSPFASG 1570 1580 1590 1600 1610 1620 EASRPESVAE SVKDEAGKAE SRRESIAKTH KDESSLDKAK EQESRRESLA ESIKPESGID 1630 1640 1650 1660 1670 1680 EKSALASKEA SRPESVTDKS KEPSRRESIA ESLKAESTKD EKSAPPSKEA SRPGSVVESV 1690 1700 1710 1720 1730 1740 KDETEKSKEP SRRESIAESA KPPIEFREVS RPESVIDGIK DESAKPESRR DSPLASKEAS 1750 1760 1770 1780 1790 1800 RPESVLESVK DEPIKSTEKS RRESVAESFK ADSTKDEKSP LTSKDISRPE SAVENVMDAV 1810 1820 1830 1840 1850 1860 GSAERSQPES VTASRDVSRP ESVAESEKDD TDKPESVVES VIPASDVVEI EKGAADKEKG 1870 1880 1890 1900 1910 1920 VFVSLEIGKP DSPSEVISRP GPVVESVKPE SRRESSTEIV LPCHAEDSKE PSRPESKVEC 1930 1940 1950 1960 1970 1980 LKDESEVLKG STRRESVAES DKSSQPFKET SRPESAVGSM KDESMSKEPS RRESVKDGAA 1990 2000 2010 2020 2030 2040 QSRETSRPAS VAESAKDGAD DLKELSRPES TTQSKEAGSI KDEKSPLASE EASRPASVAE 2050 2060 2070 2080 2090 2100 SVKDEAEKSK EESRRESVAE KSPLPSKEAS RPASVAESIK DEAEKSKEES RRESVAEKSP 2110 2120 2130 2140 2150 2160 LPSKEASRPA SVAESIKDEA EKSKEESRRE SVAEKSPLPS KEASRPASVA ESIKDEAEKS 2170 2180 2190 2200 2210 2220 KEESRRESVA EKSPLPSKEA SRPASVAESI KDEAEKSKEE SRRESVAEKS PLPSKEASRP 2230 2240 2250 2260 2270 2280 ASVAESIKDE AEKSKEESRR ESVAEKSPLP SKEASRPASV AESIKDEAEK SKEESRRESV 2290 2300 2310 2320 2330 2340 AEKSPLPSKE ASRPASVAES IKDEAEKSKE ETRRESVAEK SPLPSKEASR PASVAESIKD 2350 2360 2370 2380 2390 2400 EAEKSKEESR RESAAEKSPL PSKEASRPAS VAESVKDEAD KSKEESRRES MAESGKAQSI 2410 2420 2430 2440 2450 2460 KGDQSPLKEV SRPESVAESV KDDPVKSKEP SRRESVAGSV TADSARDDQS PLESKGASRP 2470 2480 2490 2500 2510 2520 ESVVDSVKDE AEKQESRRES KTESVIPPKA KDDKSPKEVL QPVSMTETIR EDADQPMKPS 2530 2540 2550 2560 2570 2580 QAESRRESIA ESIKASSPRD EKSPLASKEA SRPGSVAESI KYDLDKPQII KDDKSTEHSR 2590 2600 2610 2620 2630 2640 RESLEDKSAV TSEKSVSRPL SVASDHEAAV AIEDDAKSSI SPKDKSRPGF VAETVSSPIE 2650 2660 2670 2680 2690 2700 EATMEFSKIE VVEKSSLALS LQGGSGGKLQ TDSSPVDVAE GDFSHAVASV STVTPTLTKP 2710 2720 2730 2740 2750 2760 AELAQIGAAK TVSSPLDEAL RTPSAPEHIS RADSPAECAS EEIASQDKSP QVLKESSRPA 2770 2780 2790 2800 2810 2820 WVAESKDDAA QLKSSVEDLR SPVASTEISR PASAGETASS PIEEAPKDFA EFEQAEKAVL 2830 2840 2850 2860 2870 2880 PLTIELKGNL PTLSSPVDVA HGDFPQTSTP TSSPTVASVQ PAELSKVDIE KTASSPIDEA 2890 2900 2910 2920 2930 2940 PKSLIGCPAE ERPESPAESA KDAAESVEKS KDASRPPSVV ESTKADSTKG DISPSPESVL 2950 2960 2970 2980 2990 3000 EGPKDDVEKS KESSRPPSVS ASITGDSTKD VSRPASVVES VKDEHDKAES RRESIAKVES 3010 3020 3030 3040 3050 3060 VIDEAGKSDS KSSSQDSQKD EKSTLASKEA SRRESVVESS KDDAEKSESR PESVIASGEP 3070 3080 3090 3100 3110 3120 VPRESKSPLD SKDTSRPGSM VESVTAEDEK SEQQSRRESV AESVKADTKK DGKSQEASRP 3130 3140 3150 3160 3170 3180 SSVDELLKDD DEKQESRRQS ITGSHKAMST MGDESPMDKA DKSKEPSRPE SVAESIKHEN 3190 3200 3210 3220 3230 3240 TKDEESPLGS RRDSVAESIK SDITKGEKSP LPSKEVSRPE SVVGSIKDEK AESRRESVAE 3250 3260 3270 3280 3290 3300 SVKPESSKDA TSAPPSKEHS RPESVLGSLK DEGDKTTSRR VSVADSIKDE KSLLVSQEAS 3310 3320 3330 3340 3350 3360 RPESEAESLK DAAAPSQETS RPESVTESVK DGKSPVASKE ASRPASVAEN AKDSADESKE 3370 3380 3390 3400 3410 3420 QRPESLPQSK AGSIKDEKSP LASKDEAEKS KEESRRESVA EQFPLVSKEV SRPASVAESV 3430 3440 3450 3460 3470 3480 KDEAEKSKEE SPLMSKEASR PASVAGSVKD EAEKSKEESR RESVAEKSPL PSKEASRPAS 3490 3500 3510 3520 3530 3540 VAESVKDEAD KSKEESRRES GAEKSPLASK EASRPASVAE SIKDEAEKSK EESRRESVAE 3550 3560 3570 3580 3590 3600 KSPLPSKEAS RPTSVAESVK DEAEKSKEES RRDSVAEKSP LASKEASRPA SVAESVQDEA 3610 3620 3630 3640 3650 3660 EKSKEESRRE SVAEKSPLAS KEASRPASVA ESIKDEAEKS KEESRRESVA EKSPLASKEA 3670 3680 3690 3700 3710 3720 SRPTSVAESV KDEAEKSKEE SSRDSVAEKS PLASKEASRP ASVAESVQDE AEKSKEESRR 3730 3740 3750 3760 3770 3780 ESVAEKSPLA SKEASRPASV AESVKDDAEK SKEESRRESV AEKSPLASKE ASRPASVAES 3790 3800 3810 3820 3830 3840 VKDEAEKSKE ESRRESVAEK SPLPSKEASR PTSVAESVKD EAEKSKEESR RESVAEKSSL 3850 3860 3870 3880 3890 3900 ASKKASRPAS VAESVKDEAE KSKEESRRES VAEKSPLASK EASRPASVAE SVKDEAEKSK 3910 3920 3930 3940 3950 3960 EESRRESVAE KSPLPSKEAS RPTSVAESVK DEADKSKEES RRESGAEKSP LASMEASRPT 3970 3980 3990 4000 4010 4020 SVAESVKDET EKSKEESRRE SVTEKSPLPS KEASRPTSVA ESVKDEAEKS KEESRRESVA 4030 4040 4050 4060 4070 4080 EKSPLASKES SRPASVAESI KDEAEGTKQE SRRESMPESG KAESIKGDQS SLASKETSRP 4090 4100 4110 4120 4130 4140 DSVVESVKDE TEKPEGSAID KSQVASRPES VAVSAKDEKS PLHSRPESVA DKSPDASKEA 4150 4160 4170 4180 4190 4200 SRSLSVAETA SSPIEEGPRS IADLSLPLNL TGEAKGKLPT LSSPIDVAEG DFLEVKAESS 4210 4220 4230 4240 4250 4260 PRPAVLSKPA EFSQPDTGHT ASTPVDEASP VLEEIEVVEQ HTTSGVGATG ATAETDLLDL 4270 4280 4290 4300 4310 4320 TETKSETVTK QSETTLFETL TSKVESKVEV LESSVKQVEE KVQTSVKQAE TTVTDSLEQL 4330 4340 4350 4360 4370 4380 TKKSSEQLTE IKSVLDTNFE EVAKIVADVA KVLKSDKDIT DIIPDFDERQ LEEKLKSTAD 4390 4400 4410 4420 4430 4440 TEEESDKSTR DEKSLEISVK VEIESEKSSP DQKSGPISIE EKDKIEQSEK AQLRQGILTS 4450 4460 4470 4480 4490 4500 SRPESVASQP ESVPSPSQSA ASHEHKEVEL SESHKAEKSS RPESVASQVS EKDMKTSRPA 4510 4520 4530 4540 4550 4560 SSTSQFSTKE GDEETTESLL HSLTTTETVE TKQMEEKSSF ESVSTSVTKS TVLSSQSTVQ 4570 4580 4590 4600 4610 4620 LREESTSESL SSSLKVEDSS RRESLSSLLA EKGGIATNTS LKEDTSASAS QLEELLVQSE 4630 4640 4650 4660 4670 4680 ECSSESIVSE IQTSIAQKSN KEIKDARETK VTSQFTTTTS SATKDDSLKE TVAEFLATEK 4690 4700 4710 4720 4730 4740 IVSAKEAFST EATKSADDCL KKTTASAVSS TSASQRALFV GTDESRRESL LSQASESRLT 4750 4760 4770 4780 4790 4800 HSDPEDEEPA DDVDERSSVK ESRSKSIATI MMTSIYKPSE DMEPISKLVE EEHEHVEELA 4810 4820 4830 4840 4850 4860 QEVTSTSKTT TLLQSSEQSS TTTSSTSKTG ASRVESITLT QMDQQTSQSQ GDPADRKTPP 4870 4880 4890 4900 4910 4920 TAPVSPGVKA MSSTGSAGSV IGAGAGAVAA GGKCESSAAS IVSSSGPMSP KDISGKSSPG 4930 4940 4950 4960 4970 4980 ALTSESQSIP TPLGRESHTD TPESSPKPTS PFPRVSKDEL KSLEMQHHSQ EQMLAGAAAA 4990 5000 5010 5020 5030 5040 AGAECEGDIP ELHELRGLEC TTALSGSTDK IITTTITTVT KVISADGKEI VTEQKTVTTT 5050 5060 5070 5080 5090 5100 DSSEPDSEKV VVTTTRTTSE SERDQLLPKE VALLRGLYRA STPGSEDDED LLLGSPRSAT 5110 5120 5130 5140 5150 5160 SYELQHSSSG VSKRSDLDAD GDESQDDIPP QYGSEEHSTA RSILLPRTAD PMATSFYGAL 5170 5180 5190 5200 5210 5220 PDSFDVVMKP STEPIPIQGA PSGDSQSSES VESSSQTWAG HKFLDQADKD FQRALEEHVQ 5230 5240 5250 5260 5270 5280 ARGAEVMSSV TAKYSYSPSK AEEMEQIVSG TAERQRFPLS DVQRARVAES GFATVGSVAS 5290 5300 5310 5320 5330 5340 QQQQQEKGGE VEQAVPTTTA VTASTTATAS STGALPKDRL EEWGKPLGLP SPAPLPVEGG 5350 5360 5370 5380 5390 5400 ADIRTTPKKE RRLVATKTRL NNEKNLRRRS ESPNKAGKKP APVYVDLTYV PHNGNSYYAH 5410 5420 5430 5440 5450 5460 VDFFKRVRAR YYVFSGTEPS RQVYDALLEA KQTWEDKELE VTIIPTYDTD VLGYWVAENE 5470 5480 5490 ELLAKHRIDL SPSASRCTIN LQDHETSCSA YRLEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development." Hummel T., Krukkert K., Roos J., Davis G., Klambt C. Neuron 26:357-370(2000) [PubMed: 10839355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: Oregon-R.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oregon-R.
[5]	"Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth." Roos J., Hummel T., Ng N., Klambt C., Davis G.W. Neuron 26:371-382(2000) [PubMed: 10839356] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]	"Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function." Zhang Y.Q., Bailey A.M., Matthies H.J.G., Renden R.B., Smith M.A., Speese S.D., Rubin G.M., Broadie K.S. Cell 107:591-603(2001) [PubMed: 11733059] [Abstract] Cited for: FUNCTION, INTERACTION WITH FMR1.
[7]	"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells." Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A. Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3067; SER-3071 AND SER-3075, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: ABW09325.1. AL031128 Genomic DNA. Translation: CAA20006.1. Sequence problems.
PIR	T13564.
RefSeq	NP_001096864.1. NM_001103394.2.
UniGene	Dm.6254.
3D structure databases
ProteinModelPortal	Q9W596.
SMR	Q9W596. Positions 347-402.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9W596. 1 interaction.
STRING	Q9W596.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0112628; FBpp0111540; FBgn0259108. FBtr0307597; FBpp0300235; FBgn0259108. FBtr0307598; FBpp0300236; FBgn0259108.
GeneID	5740544.
KEGG	dme:Dmel_CG34387.
NMPDR	fig|7227.3.peg.16056.
Organism-specific databases
CTD	5740544.
FlyBase	FBgn0259108. futsch.
Phylogenomic databases
eggNOG	inNOG07463.
GeneTree	EMGT00050000000593.
OrthoDB	EOG47SQVR.
PhylomeDB	Q9W596.
Gene expression databases
Bgee	Q9W596.
GermOnline	CG3064. Drosophila melanogaster.
Family and domain databases
InterPro	IPR009603. DUF1213. [Graphical view]
Pfam	PF06740. DUF1213. 53 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUTSC_DROME

Accession

Primary (citable) accession number: Q9W596
Secondary accession number(s): A8JTS2, O76891

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 81 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project