Reviewed, UniProtKB/Swiss-Prot Q9W552 (VPS26_DROME)

Names and origin

Protein names

Recommended name:
    Vacuolar protein sorting-associated protein 26
Alternative name(s):
    VPS26 protein homolog

Gene names

ORF Names:

CG14804

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in vesicular protein sorting, similar to the yeast retromer proteins By similarity.
Sequence similarities	Belongs to the VPS26 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW vacuolar transport Inferred from electronic annotation. Source: InterPro
Cellular component	retromer complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Vacuolar protein sorting-associated protein 26		PRO_0000073011
Experimental info
	Sequence conflict	94	1	R → G in CAA15940. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9W552-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F9F9E108A8B60B26	FASTA	478	52,656
	10 20 30 40 50 60 MNFLGFGQSA DIEIVFDGAE HKTAEVKGED GKVEKMLLFY DGETVSGKVN VTLKKPGSKL 70 80 90 100 110 120 EHQGIKIEFI GQIELYYDRG NHHEFKCLAK ALARPGDLIQ NNSYPFDFPK VEKQFEVYAG 130 140 150 160 170 180 SNVRLRYFLR ATIVRRISDI TKEVDIAVHT LCSYPEMNNP IKMEVGIEDC LHIEFEYNKS 190 200 210 220 230 240 KYHLRDTIIG KIYFLLVRIK IKHMEIAIIK KESTGTGPTM FNENETIAKY EIMDGAPVKG 250 260 270 280 290 300 ESIPIRVFLA GYNLTPTMRD INKKFSVKYF LNLVLMDTED RRYFKQQEIT LWRKADKPRY 310 320 330 340 350 360 HGAQQHQQQQ HQHVPLHAPP HLVSGPAAPT VAHSLISSST DSGEVGGAPT APGTAGSESK 370 380 390 400 410 420 MGLFTRESPN QEFSQQQMDS PPLTPTPSTA SVAVAVPTAA SSVSEPAPER GIGDGAAAAT 430 440 450 460 470 TSASPVAMLS SSPPPLLPVS PLSRSETEAS EQVQPEDEDL DAITPNTKKT GATPLATD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oregon-R.
[4]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-478. Strain: Berkeley. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014298 Genomic DNA. Translation: AAF45679.1. AL021106 Genomic DNA. Translation: CAA15940.1. BT023502 mRNA. Translation: AAY84902.1. AY060842 mRNA. Translation: AAL28390.1. Different initiation.
PIR	T12683.
RefSeq	NP_569952.2.
UniGene	Dm.11603
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9W552.
Genome annotation databases
Ensembl	FBgn0014411. Drosophila melanogaster. [Contig view]
GeneID	31144.
KEGG	dme:Dmel_CG14804.
NMPDR	fig|7227.3.peg.16124.
Organism-specific databases
FlyBase	FBgn0014411. CG14804.
Phylogenomic databases
HOGENOM	Q9W552.
OMA	Q9W552. VVRKSMS.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-000248-MON.
Gene expression databases
ArrayExpress	Q9W552.
GermOnline	CG14804. Drosophila melanogaster.
Family and domain databases
InterPro	IPR005377. Vps26. [Graphical view]
PANTHER	PTHR12233:SF1. Vps26. 1 hit.
Pfam	PF03643. Vps26. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	772132.

Entry information

Entry name

VPS26_DROME

Accession

Primary (citable) accession number: Q9W552
Secondary accession number(s): O46088, Q4QQB4, Q95SD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project