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Q9W541

- Q9W541_DROME

UniProt

Q9W541 - Q9W541_DROME

Protein
Submitted name:

EIF2B-epsilon protein

Gene

eIF2B-epsilon

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: FlyBase
    2. nucleotidyltransferase activity Source: UniProtKB-KW
    3. translation initiation factor activity Source: FlyBase

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. translational initiation Source: FlyBase

    Keywords - Molecular functioni

    NucleotidyltransferaseImported, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_210104. Recycling of eIF2:GDP.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    EIF2B-epsilon proteinImported
    Submitted name:
    LD41433pImported
    Submitted name:
    eIF2B-epsilon, isoform AImported (EC:2.7.7.-Imported)
    Submitted name:
    eIF2B-epsilon, isoform BImported (EC:2.7.7.-Imported)
    Gene namesi
    Name:eIF2B-epsilonImported
    Synonyms:eIF-2b(epsilon)Imported
    ORF Names:CG3806Imported, Dmel_CG3806Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0023512. eIF2B-epsilon.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: FlyBase
    2. eukaryotic translation initiation factor 2B complex Source: FlyBase

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1596941.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00510000047568.
    InParanoidiQ9W541.
    KOiK03240.
    OMAiEGKGYIW.

    Family and domain databases

    Gene3Di1.25.40.180. 1 hit.
    3.90.550.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR001451. Hexapep_transf.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR003307. W2_domain.
    [Graphical view]
    PfamiPF00132. Hexapep. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view]
    SMARTiSM00515. eIF5C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF53448. SSF53448. 2 hits.
    PROSITEiPS51363. W2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9W541-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQFEKEIVQ AVLIADNNVW NFKPLSDEGS TALLPLVNVR MLDYALMALN    50
    RSGVEEVFVY TSLYRSSIRE HIRAGIATDA AWSFKMTVHV IGGEGCRCFG 100
    DAMRDLDNKA LIRGHFILLG ADTVTNADLR PVLEQHKRQA KFDKGTAATL 150
    VFKECANNVR TGNEVLIAVD RRNDRLHYHQ RLRMHHKENR YQLPLDVFLG 200
    NSCVALHHNL LDPQIAIGSP SMLSLFNDNF DFQTRDDFVR GLLINEELLD 250
    SRIYVALLPA AQYAHKVNNW PAYQLVSRDI INRWAYPFVP DIGLYKLQQE 300
    YVFHKDNIYK SPEAHVSKVA LLQNVVIEAG SHVDSGSVIS DSVIGANCRI 350
    GKNCRLTNAF LMADVTVMDN CRLEHCVVGE GAIINEDCDV SAGCVLGAKS 400
    VLPAKKTLAK TLITRTPSRR RSDDEVVVEL KSIGPHAYIV SDLTTGDPED 450
    SECEDLLPQQ PLSIPKMGDL LAPLDEISYC SDFSEDDEDA SRAVTPLPDD 500
    TNIFLGEVID SLTRGFREKS NPDFLVLEIN SSRYAYNMSL KEVNFNVVKA 550
    VFGMQSIVEP ANDNVLVAIN AAFKQLGPVV SNYIKSEDSM MDCLKALEDV 600
    YEENHLVRGK ISQIVHYLYD KDFVSESAIQ AWYAQLDEEE HAHLRQSLAK 650
    LVAWLDQSSE EDDDEEDDD 669
    Length:669
    Mass (Da):75,019
    Last modified:May 1, 2000 - v1
    Checksum:iC25B1D7A1A516BA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF45695.1.
    AY095053 mRNA. Translation: AAM11381.1.
    AE014298 Genomic DNA. Translation: AAS65247.1.
    AJ344150 mRNA. Translation: CAC82995.1.
    RefSeqiNP_569961.2. NM_130605.4.
    NP_996329.1. NM_206606.2.
    UniGeneiDm.3467.

    Genome annotation databases

    EnsemblMetazoaiFBtr0070350; FBpp0070336; FBgn0023512.
    FBtr0070351; FBpp0089217; FBgn0023512.
    GeneIDi31156.
    KEGGidme:Dmel_CG3806.
    UCSCiCG3806-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF45695.1 .
    AY095053 mRNA. Translation: AAM11381.1 .
    AE014298 Genomic DNA. Translation: AAS65247.1 .
    AJ344150 mRNA. Translation: CAC82995.1 .
    RefSeqi NP_569961.2. NM_130605.4.
    NP_996329.1. NM_206606.2.
    UniGenei Dm.3467.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1596941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0070350 ; FBpp0070336 ; FBgn0023512 .
    FBtr0070351 ; FBpp0089217 ; FBgn0023512 .
    GeneIDi 31156.
    KEGGi dme:Dmel_CG3806.
    UCSCi CG3806-RA. d. melanogaster.

    Organism-specific databases

    CTDi 31156.
    FlyBasei FBgn0023512. eIF2B-epsilon.

    Phylogenomic databases

    GeneTreei ENSGT00510000047568.
    InParanoidi Q9W541.
    KOi K03240.
    OMAi EGKGYIW.

    Enzyme and pathway databases

    Reactomei REACT_210104. Recycling of eIF2:GDP.

    Miscellaneous databases

    GenomeRNAii 31156.
    NextBioi 772206.
    PROi Q9W541.

    Family and domain databases

    Gene3Di 1.25.40.180. 1 hit.
    3.90.550.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR001451. Hexapep_transf.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR003307. W2_domain.
    [Graphical view ]
    Pfami PF00132. Hexapep. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view ]
    SMARTi SM00515. eIF5C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF53448. SSF53448. 2 hits.
    PROSITEi PS51363. W2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Pomar N.
      Thesis (2001), Department of Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Characterization of the Drosophila melanogaster eIF2B."
      Pomar N., de Haro C.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    5. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    6. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BerkeleyImported.
    9. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    10. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    11. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    14. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9W541_DROME
    AccessioniPrimary (citable) accession number: Q9W541
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3