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Q9W541

- Q9W541_DROME

UniProt

Q9W541 - Q9W541_DROME

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Protein
Submitted name: EIF2B-epsilon protein
Gene
eIF2B-epsilon, eIF-2b(epsilon), CG3806, Dmel_CG3806
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: FlyBase
  2. nucleotidyltransferase activity Source: UniProtKB-KW
  3. translation initiation factor activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. regulation of GTPase activity Source: GOC
  2. translational initiation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_210104. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Submitted name:
EIF2B-epsilon proteinImported
Submitted name:
LD41433pImported
Submitted name:
eIF2B-epsilon, isoform AImported (EC:2.7.7.-Imported)
Submitted name:
eIF2B-epsilon, isoform BImported (EC:2.7.7.-Imported)
Gene namesi
Name:eIF2B-epsilonImported
Synonyms:eIF-2b(epsilon)Imported
ORF Names:CG3806Imported, Dmel_CG3806Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023512. eIF2B-epsilon.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: FlyBase
  2. eukaryotic translation initiation factor 2B complex Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-1596941.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00510000047568.
InParanoidiQ9W541.
KOiK03240.
OMAiEGKGYIW.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep_transf.
IPR016021. MIF4-like_typ_1/2/3.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W541-1 [UniParc]FASTAAdd to Basket

« Hide

MAQFEKEIVQ AVLIADNNVW NFKPLSDEGS TALLPLVNVR MLDYALMALN    50
RSGVEEVFVY TSLYRSSIRE HIRAGIATDA AWSFKMTVHV IGGEGCRCFG 100
DAMRDLDNKA LIRGHFILLG ADTVTNADLR PVLEQHKRQA KFDKGTAATL 150
VFKECANNVR TGNEVLIAVD RRNDRLHYHQ RLRMHHKENR YQLPLDVFLG 200
NSCVALHHNL LDPQIAIGSP SMLSLFNDNF DFQTRDDFVR GLLINEELLD 250
SRIYVALLPA AQYAHKVNNW PAYQLVSRDI INRWAYPFVP DIGLYKLQQE 300
YVFHKDNIYK SPEAHVSKVA LLQNVVIEAG SHVDSGSVIS DSVIGANCRI 350
GKNCRLTNAF LMADVTVMDN CRLEHCVVGE GAIINEDCDV SAGCVLGAKS 400
VLPAKKTLAK TLITRTPSRR RSDDEVVVEL KSIGPHAYIV SDLTTGDPED 450
SECEDLLPQQ PLSIPKMGDL LAPLDEISYC SDFSEDDEDA SRAVTPLPDD 500
TNIFLGEVID SLTRGFREKS NPDFLVLEIN SSRYAYNMSL KEVNFNVVKA 550
VFGMQSIVEP ANDNVLVAIN AAFKQLGPVV SNYIKSEDSM MDCLKALEDV 600
YEENHLVRGK ISQIVHYLYD KDFVSESAIQ AWYAQLDEEE HAHLRQSLAK 650
LVAWLDQSSE EDDDEEDDD 669
Length:669
Mass (Da):75,019
Last modified:May 1, 2000 - v1
Checksum:iC25B1D7A1A516BA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAF45695.1.
AY095053 mRNA. Translation: AAM11381.1.
AE014298 Genomic DNA. Translation: AAS65247.1.
AJ344150 mRNA. Translation: CAC82995.1.
RefSeqiNP_569961.2. NM_130605.4.
NP_996329.1. NM_206606.2.
UniGeneiDm.3467.

Genome annotation databases

EnsemblMetazoaiFBtr0070350; FBpp0070336; FBgn0023512.
FBtr0070351; FBpp0089217; FBgn0023512.
GeneIDi31156.
KEGGidme:Dmel_CG3806.
UCSCiCG3806-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAF45695.1 .
AY095053 mRNA. Translation: AAM11381.1 .
AE014298 Genomic DNA. Translation: AAS65247.1 .
AJ344150 mRNA. Translation: CAC82995.1 .
RefSeqi NP_569961.2. NM_130605.4.
NP_996329.1. NM_206606.2.
UniGenei Dm.3467.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

MINTi MINT-1596941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0070350 ; FBpp0070336 ; FBgn0023512 .
FBtr0070351 ; FBpp0089217 ; FBgn0023512 .
GeneIDi 31156.
KEGGi dme:Dmel_CG3806.
UCSCi CG3806-RA. d. melanogaster.

Organism-specific databases

CTDi 31156.
FlyBasei FBgn0023512. eIF2B-epsilon.

Phylogenomic databases

GeneTreei ENSGT00510000047568.
InParanoidi Q9W541.
KOi K03240.
OMAi EGKGYIW.

Enzyme and pathway databases

Reactomei REACT_210104. Recycling of eIF2:GDP.

Miscellaneous databases

GenomeRNAii 31156.
NextBioi 772206.
PROi Q9W541.

Family and domain databases

Gene3Di 1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR001451. Hexapep_transf.
IPR016021. MIF4-like_typ_1/2/3.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR003307. W2_domain.
[Graphical view ]
Pfami PF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view ]
SMARTi SM00515. eIF5C. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEi PS51363. W2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Pomar N.
    Thesis (2001), Department of Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Characterization of the Drosophila melanogaster eIF2B."
    Pomar N., de Haro C.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  6. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  9. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  10. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  14. FlyBase
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9W541_DROME
AccessioniPrimary (citable) accession number: Q9W541
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi