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Protein
Submitted name:

EIF2B-epsilon protein

Gene

eIF2B-epsilon

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: FlyBase
  • nucleotidyltransferase activity Source: UniProtKB-KW
  • translation initiation factor activity Source: FlyBase

GO - Biological processi

  • translational initiation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Submitted name:
EIF2B-epsilon proteinImported
Submitted name:
LD41433pImported
Submitted name:
eIF2B-epsilon, isoform AImported (EC:2.7.7.-Imported)
Submitted name:
eIF2B-epsilon, isoform BImported
Gene namesi
Name:eIF2B-epsilonImported
Synonyms:eIF-2b(epsilon)Imported
ORF Names:CG3806Imported, Dmel_CG3806Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023512. eIF2B-epsilon.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: FlyBase
  • eukaryotic translation initiation factor 2B complex Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0023512.

Interactioni

Protein-protein interaction databases

MINTiMINT-1596941.
STRINGi7227.FBpp0089217.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini498 – 665W2InterPro annotationAdd BLAST168

Phylogenomic databases

eggNOGiKOG1461. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00510000047568.
KOiK03240.
OMAiNDMEDCY.
OrthoDBiEOG091G065U.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep.
IPR016021. MIF4-like.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFEKEIVQ AVLIADNNVW NFKPLSDEGS TALLPLVNVR MLDYALMALN
60 70 80 90 100
RSGVEEVFVY TSLYRSSIRE HIRAGIATDA AWSFKMTVHV IGGEGCRCFG
110 120 130 140 150
DAMRDLDNKA LIRGHFILLG ADTVTNADLR PVLEQHKRQA KFDKGTAATL
160 170 180 190 200
VFKECANNVR TGNEVLIAVD RRNDRLHYHQ RLRMHHKENR YQLPLDVFLG
210 220 230 240 250
NSCVALHHNL LDPQIAIGSP SMLSLFNDNF DFQTRDDFVR GLLINEELLD
260 270 280 290 300
SRIYVALLPA AQYAHKVNNW PAYQLVSRDI INRWAYPFVP DIGLYKLQQE
310 320 330 340 350
YVFHKDNIYK SPEAHVSKVA LLQNVVIEAG SHVDSGSVIS DSVIGANCRI
360 370 380 390 400
GKNCRLTNAF LMADVTVMDN CRLEHCVVGE GAIINEDCDV SAGCVLGAKS
410 420 430 440 450
VLPAKKTLAK TLITRTPSRR RSDDEVVVEL KSIGPHAYIV SDLTTGDPED
460 470 480 490 500
SECEDLLPQQ PLSIPKMGDL LAPLDEISYC SDFSEDDEDA SRAVTPLPDD
510 520 530 540 550
TNIFLGEVID SLTRGFREKS NPDFLVLEIN SSRYAYNMSL KEVNFNVVKA
560 570 580 590 600
VFGMQSIVEP ANDNVLVAIN AAFKQLGPVV SNYIKSEDSM MDCLKALEDV
610 620 630 640 650
YEENHLVRGK ISQIVHYLYD KDFVSESAIQ AWYAQLDEEE HAHLRQSLAK
660
LVAWLDQSSE EDDDEEDDD
Length:669
Mass (Da):75,019
Last modified:May 1, 2000 - v1
Checksum:iC25B1D7A1A516BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45695.1.
AY095053 mRNA. Translation: AAM11381.1.
AE014298 Genomic DNA. Translation: AAS65247.1.
AJ344150 mRNA. Translation: CAC82995.1.
RefSeqiNP_569961.2. NM_130605.5.
NP_996329.1. NM_206606.3.
UniGeneiDm.3467.

Genome annotation databases

EnsemblMetazoaiFBtr0070350; FBpp0070336; FBgn0023512.
FBtr0070351; FBpp0089217; FBgn0023512.
GeneIDi31156.
KEGGidme:Dmel_CG3806.
UCSCiCG3806-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45695.1.
AY095053 mRNA. Translation: AAM11381.1.
AE014298 Genomic DNA. Translation: AAS65247.1.
AJ344150 mRNA. Translation: CAC82995.1.
RefSeqiNP_569961.2. NM_130605.5.
NP_996329.1. NM_206606.3.
UniGeneiDm.3467.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1596941.
STRINGi7227.FBpp0089217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070350; FBpp0070336; FBgn0023512.
FBtr0070351; FBpp0089217; FBgn0023512.
GeneIDi31156.
KEGGidme:Dmel_CG3806.
UCSCiCG3806-RA. d. melanogaster.

Organism-specific databases

CTDi31156.
FlyBaseiFBgn0023512. eIF2B-epsilon.

Phylogenomic databases

eggNOGiKOG1461. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00510000047568.
KOiK03240.
OMAiNDMEDCY.
OrthoDBiEOG091G065U.

Enzyme and pathway databases

ReactomeiR-DME-72731. Recycling of eIF2:GDP.

Miscellaneous databases

ChiTaRSieIF2B-epsilon. fly.
GenomeRNAii31156.

Gene expression databases

BgeeiFBgn0023512.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep.
IPR016021. MIF4-like.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9W541_DROME
AccessioniPrimary (citable) accession number: Q9W541
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.