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Q9W4S9

- PDE4C_DROME

UniProt

Q9W4S9 - PDE4C_DROME

Protein

cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G

Gene

dnc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity. Vital for female fertility. Required for learning/memory By similarity.By similarity

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei645 – 6451Proton donorBy similarity
    Metal bindingi649 – 6491Divalent metal cation 1By similarity
    Metal bindingi685 – 6851Divalent metal cation 1By similarity
    Metal bindingi686 – 6861Divalent metal cation 1By similarity
    Metal bindingi686 – 6861Divalent metal cation 2By similarity
    Binding sitei686 – 6861cAMPBy similarity
    Metal bindingi803 – 8031Divalent metal cation 1By similarity
    Binding sitei803 – 8031cAMPBy similarity
    Sitei806 – 8061Binds AMP, but not cAMPBy similarity
    Binding sitei854 – 8541cAMPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi645 – 6495cAMPBy similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. associative learning Source: FlyBase
    2. axon extension Source: FlyBase
    3. behavioral response to ethanol Source: FlyBase
    4. cAMP catabolic process Source: UniProtKB-UniPathway
    5. cAMP-mediated signaling Source: FlyBase
    6. circadian rhythm Source: FlyBase
    7. conditioned taste aversion Source: FlyBase
    8. courtship behavior Source: FlyBase
    9. lateral inhibition Source: FlyBase
    10. learning Source: FlyBase
    11. learning or memory Source: FlyBase
    12. locomotor rhythm Source: FlyBase
    13. mating behavior Source: FlyBase
    14. memory Source: FlyBase
    15. nonassociative learning Source: FlyBase
    16. olfactory learning Source: FlyBase
    17. oogenesis Source: FlyBase
    18. regulation of protein kinase A signaling Source: FlyBase
    19. reproduction Source: FlyBase
    20. short-term memory Source: FlyBase
    21. synaptic transmission Source: FlyBase
    22. thermosensory behavior Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_209420. G alpha (s) signalling events.
    REACT_213958. DARPP-32 events.
    UniPathwayiUPA00762; UER00747.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G (EC:3.1.4.53)
    Alternative name(s):
    Learning/memory process protein
    Protein dunce
    Gene namesi
    Name:dncImported
    ORF Names:CG32498
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0000479. dnc.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 983983cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/GPRO_0000198818Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ9W4S9.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi57834. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9W4S9.
    SMRiQ9W4S9. Positions 465-499, 574-896.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi212 – 28978Ser-richAdd
    BLAST
    Compositional biasi933 – 98250Gly-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00660000095451.
    InParanoidiQ9W4S9.
    KOiK01120.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequences (12)i

    Sequence statusi: Complete.

    This entry describes 12 isoformsi produced by alternative splicing. Align

    Isoform N1 Publication (identifier: Q9W4S9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIATLFIIFA FIRAFPWSRK RGRPALALTL MPEGGEDHRG DLNQKGENNN    50
    RPRPSISLAN NGEAMAPRTR RKSSKFHEVT FSGSVGGGDS DGGGEAINGG 100
    NLDVSPSKRH SLSTTTSNSS SAPYRYLSGS SRSRGSRGDC HEYYQLQQHS 150
    SSLSNGNRGN RGLSQRSDTM ATEAEGEEFD VDPMDEDDED QTYDRETEEF 200
    YSNIQDAAGT GSSSRSKRSS LFSRSDSSAT TTSSSGGGTF TGGKRRSAAS 250
    ILSSSMCSDL MTSDRRSSTA TEYSVKSVTT GNTSQRRSSG RIRRYVSRMT 300
    IAGARRRTTG SFDVENGQGA RSPLEGGSPS AGLVLQNLPQ RRESFLYRSD 350
    SDFEMSPKSM SRNSSIASES HGEDLIVTPF AQILASLRSV RNNLLSLTNV 400
    PASNKSRRPN QSSSASRSGN PPGAPLSQGE EAYTRLATDT IEELDWCLDQ 450
    LETIQTHRSV SDMASLKFKR MLNKELSHFS ESSRSGNQIS EYICSTFLDK 500
    QQEFDLPSLR VEDNPELVAA NAAAGQQSAG QYARSRSPRG PPMSQISGVK 550
    RPLSHTNSFT GERLPTFGVE TPRENELGTL LGELDTWGIQ IFSIGEFSVN 600
    RPLTCVAYTI FQSRELLTSL MIPPKTFLNF MSTLEDHYVK DNPFHNSLHA 650
    ADVTQSTNVL LNTPALEGVF TPLEVGGALF AACIHDVDHP GLTNQFLVNS 700
    SSELALMYND ESVLENHHLA VAFKLLQNQG CDIFCNMQKK QRQTLRKMVI 750
    DIVLSTDMSK HMSLLADLKT MVETKKVAGS GVLLLDNYTD RIQVLENLVH 800
    CADLSNPTKP LPLYKRWVAL LMEEFFLQGD KERESGMDIS PMCDRHNATI 850
    EKSQVGFIDY IVHPLWETWA DLVHPDAQDI LDTLEENRDY YQSMIPPSPP 900
    PSGVDENPQE DRIRFQVTLE ESDQENLAEL EEGDESGGES TTTGTTGTTA 950
    ASALSGAGGG GGGGGGMAPR TGGCQNQPQH GGM 983

    Note: No experimental confirmation available.Curated

    Length:983
    Mass (Da):107,341
    Last modified:July 5, 2004 - v2
    Checksum:i374785B501D6D73E
    GO
    Isoform G1 Publication (identifier: Q9W4S9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-169: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:814
    Mass (Da):89,085
    Checksum:i9185480204813E89
    GO
    Isoform F1 Publication (identifier: Q8IRU4-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q8IRU4.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.Curated

    Length:662
    Mass (Da):72,954
    GO
    Isoform IBy similarity (identifier: Q9W4T4-1) [UniParc]FASTAAdd to Basket

    Also known as: B1 Publication

    , S

    The sequence of this isoform can be found in the external entry Q9W4T4.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,209
    Mass (Da):129,413
    GO
    Isoform IIBy similarity (identifier: P12252-1) [UniParc]FASTAAdd to Basket

    Also known as: I1 Publication

    , J1 Publication

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,070
    Mass (Da):115,079
    GO
    Isoform III (identifier: P12252-7) [UniParc]FASTAAdd to Basket

    Also known as: E, P

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by alternative initiation at Met-429 of isoform II.

    Length:642
    Mass (Da):70,625
    GO
    Isoform IVBy similarity (identifier: P12252-3) [UniParc]FASTAAdd to Basket

    Also known as: A1 Publication

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:701
    Mass (Da):77,193
    GO
    Isoform VBy similarity (identifier: P12252-4) [UniParc]FASTAAdd to Basket

    Also known as: C1 Publication

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,057
    Mass (Da):113,506
    GO
    Isoform VIBy similarity (identifier: P12252-5) [UniParc]FASTAAdd to Basket

    Also known as: D1 Publication

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,068
    Mass (Da):114,836
    GO
    Isoform VIIBy similarity (identifier: P12252-6) [UniParc]FASTAAdd to Basket

    Also known as: L1 Publication

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:521
    Mass (Da):57,358
    GO
    Isoform R (identifier: P12252-8) [UniParc] [UniParc]FASTAAdd to Basket

    Also known as: Q

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:703
    Mass (Da):77,368
    GO
    Isoform U (identifier: P12252-9) [UniParc]FASTAAdd to Basket

    Also known as: T

    The sequence of this isoform can be found in the external entry P12252.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:715
    Mass (Da):78,887
    GO

    Sequence cautioni

    The sequence CAB57995.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 169169Missing in isoform G. 1 PublicationVSP_051775Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF45863.2.
    AE014298 Genomic DNA. Translation: AAN09605.2.
    AL121800 Genomic DNA. Translation: CAB57995.1. Sequence problems.
    RefSeqiNP_726856.1. NM_166968.3. [Q9W4S9-1]
    NP_726858.2. NM_166970.2. [Q9W4S9-2]
    UniGeneiDm.4817.

    Genome annotation databases

    EnsemblMetazoaiFBtr0070519; FBpp0070495; FBgn0000479. [Q9W4S9-1]
    GeneIDi31309.
    KEGGidme:Dmel_CG32498.
    UCSCiCG32498-RA. d. melanogaster. [Q9W4S9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF45863.2 .
    AE014298 Genomic DNA. Translation: AAN09605.2 .
    AL121800 Genomic DNA. Translation: CAB57995.1 . Sequence problems.
    RefSeqi NP_726856.1. NM_166968.3. [Q9W4S9-1 ]
    NP_726858.2. NM_166970.2. [Q9W4S9-2 ]
    UniGenei Dm.4817.

    3D structure databases

    ProteinModelPortali Q9W4S9.
    SMRi Q9W4S9. Positions 465-499, 574-896.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 57834. 7 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0070519 ; FBpp0070495 ; FBgn0000479 . [Q9W4S9-1 ]
    GeneIDi 31309.
    KEGGi dme:Dmel_CG32498.
    UCSCi CG32498-RA. d. melanogaster. [Q9W4S9-1 ]

    Organism-specific databases

    CTDi 31309.
    FlyBasei FBgn0000479. dnc.

    Phylogenomic databases

    GeneTreei ENSGT00660000095451.
    InParanoidi Q9W4S9.
    KOi K01120.

    Enzyme and pathway databases

    UniPathwayi UPA00762 ; UER00747 .
    Reactomei REACT_209420. G alpha (s) signalling events.
    REACT_213958. DARPP-32 events.

    Miscellaneous databases

    ChiTaRSi dnc. drosophila.
    GenomeRNAii 31309.
    NextBioi 772953.

    Gene expression databases

    Bgeei Q9W4S9.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 170-479.
      Strain: Oregon-R.

    Entry informationi

    Entry nameiPDE4C_DROME
    AccessioniPrimary (citable) accession number: Q9W4S9
    Secondary accession number(s): Q8IRU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3