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Protein

Neurobeachin

Gene

rg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body.5 Publications

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

GO - Biological processi

  • compound eye cone cell differentiation Source: FlyBase
  • eye photoreceptor cell development Source: UniProtKB
  • mushroom body development Source: FlyBase
  • neuromuscular junction development Source: FlyBase
  • olfactory learning Source: FlyBase
  • protein localization Source: FlyBase
  • short-term memory Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9W4E2.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurobeachin
Alternative name(s):
A-kinase anchor protein 550
Short name:
AKAP 550
Protein rugose
dAKAP550
Gene namesi
Name:rg
Synonyms:Akap550
ORF Names:CG44835
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0266098. rg.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • neuronal cell body Source: FlyBase
  • perikaryon Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants are viable and fertile but display a rough eye surface phenotype, impaired short-term memory, aberrant associative odor learning, aberrant neuromuscular junction morphology with increased numbers of synaptic boutons, and defective axonal morphology of the Kenyon cells, the neurons of the mushroom body.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34663466NeurobeachinPRO_0000051093Add
BLAST

Proteomic databases

PaxDbiQ9W4E2.
PRIDEiQ9W4E2.

Expressioni

Tissue specificityi

In early embryos, ubiquitous expression with elevated levels in ventral furrow and flanking mesectodermal cells, neuroblasts and mesoderm. Late embryos show reduced expression in epidermis and skeletal muscle and elevated in nervous system, gut endothelium, tracheal system and salivary gland. Larvae show expression in imaginal disks and many neural cells. Developing eye imaginal disk shows expression throughout the disk and in the region of the morphogenetic furrow. Ubiquitous expression in adults with higher levels in head region. Expressed in larval neurons but not in larval glia.3 Publications

Developmental stagei

All stages of development.1 Publication

Gene expression databases

BgeeiFBgn0086911.
GenevisibleiQ9W4E2. DM.

Interactioni

Subunit structurei

Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways.4 Publications

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

Protein-protein interaction databases

BioGridi69112. 12 interactions.
DIPiDIP-17945N.
IntActiQ9W4E2. 2 interactions.
STRINGi7227.FBpp0288527.

Structurei

3D structure databases

ProteinModelPortaliQ9W4E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1846 – 188843WD 1Sequence analysisAdd
BLAST
Domaini2666 – 2774109BEACH-type PHPROSITE-ProRule annotationAdd
BLAST
Domaini2793 – 3082290BEACHPROSITE-ProRule annotationAdd
BLAST
Repeati3241 – 328444WD 2Sequence analysisAdd
BLAST
Repeati3298 – 333841WD 3Sequence analysisAdd
BLAST
Repeati3380 – 341940WD 4Sequence analysisAdd
BLAST
Repeati3422 – 346140WD 5Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi419 – 546128Ala-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi559 – 5646Poly-SerSequence analysis
Compositional biasi1363 – 140543Asn-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi1419 – 1695277Glu-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi2163 – 219432Thr-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi2298 – 231215Gln-richPROSITE-ProRule annotationAdd
BLAST

Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.1 Publication

Sequence similaritiesi

Belongs to the WD repeat neurobeachin family.Curated
Contains 1 BEACH domain.PROSITE-ProRule annotation
Contains 1 BEACH-type PH domain.PROSITE-ProRule annotation
Contains 5 WD repeats.Sequence analysis

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1787. Eukaryota.
ENOG410XNQC. LUCA.
InParanoidiQ9W4E2.
OrthoDBiEOG091G024D.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 2 hits.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NImported (identifier: Q9W4E2-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADIMRPPYS EIKRPDEIVR MTTADNLKFA VLIGLIEVGQ VTNREVVNTV
60 70 80 90 100
LHLLVGGEFD MELNFVIQDA QNIKHMLELL DHCPPNLQAE IWSVFIAILR
110 120 130 140 150
KSVRNLQACT DVGLIEHVLV RLQRSETVVA DLLIEMLGVL ASYSITVKEL
160 170 180 190 200
KLLFGTMKAT NGKWPRHSAK LLNVLRQMPH RNGPDVFFSF PGRKGSAMVL
210 220 230 240 250
PPLAKWPYEN GFTFTTWFRL DPINSVNIER EKPYLYCFKT SKGVGYTAHF
260 270 280 290 300
VGNCLVLTSM KVKGKGFQHC VKYEFQPRKW YMIAIVYIYN RWTKSEIKCL
310 320 330 340 350
VNGQLASSTE MAWFVSTNDP FDKCYIGATP ELDEERVFCG QMSAIYLFSE
360 370 380 390 400
ALTTQQICAM HRLGPGYKSQ FRFDNECYLN LPDNHKRVSH FQLLPATLGA
410 420 430 440 450
SALSGGSGSG TGSGTGNDAS AAAAAAVAAG QQQQLQLQFQ ILAAEQEARA
460 470 480 490 500
IDWSDEKLDL NAAFVKIRAV LTARNAVTLA GSSSTGTTAV ATAAAAAAAA
510 520 530 540 550
GAGAGTTAAA TSAAAAAAAT QNENDAAVGQ QQHATHHHAT AATGSADDPL
560 570 580 590 600
GHLPTGNASS SSSSFEQLRR MSSVSSLNSM VGSADTEEVN QLKAVLYDGK
610 620 630 640 650
LSNAIVFMYN PVATDGQLCL QSSPKGNVSY FVHTPHALML QDVKAVVTHS
660 670 680 690 700
IHCTLNSIGG IQVLFPLFSQ LDMAHEGLGD IKRDPTLCSK LLGFICELVE
710 720 730 740 750
TSQTVQQHMI QNRGFLVISF MLQRSSREHL TLEVLGSFLN LTKYLVTCLS
760 770 780 790 800
ANSDLLLKQL FCFSFLTWQL LDHVLFNPAL WIYTPANVQA RLYSYLATEF
810 820 830 840 850
LSDTQIYSNV RRVSTVLQTV HTLKYYYWVV NPRAKSGIIP KGLDGPRPAQ
860 870 880 890 900
KDILAIRAYI LLFLKQLIMI GNGVKEDELQ SILNYLTTMH EDENLHDVLQ
910 920 930 940 950
MLISLMSEHP SSMVPAFDVK HGVRSIFKLL AAESQLIRLQ ALKLLGFFLS
960 970 980 990 1000
RSTHKRKYDV MSPHNLYTLL AERLLLYEES LSLPTYNVLY EIMTEHISQQ
1010 1020 1030 1040 1050
ILYTRHPEPE SHYRLENPMI LKVVATLIRQ SKQTESLIDV KKLFLQDMTL
1060 1070 1080 1090 1100
LCNSNRENRR TVLQMSVWQE WLIAMAYIHP KSSEEQKISD MVYSLFRMLL
1110 1120 1130 1140 1150
HHAIKHEYGG WRVWVDTLAI VHSKVSYEEF KLQFAQMYEH YERQRTDNIT
1160 1170 1180 1190 1200
DPALRQARPI STISGWEREE LHQQQNGGSA AAVATNQTAA VKGSVSIASL
1210 1220 1230 1240 1250
EDVPPVVEEE VEELELEEVE IQEGPITEET EQKSVIANIS DVYNEQLKTD
1260 1270 1280 1290 1300
ATCNGNLEDV KEEEPVQQQI GDLEKQPEPS TPLGALRETL QLGDDMDVEE
1310 1320 1330 1340 1350
LELATAKDAL NAEQHVSRVL QASEAALNDC KMAVDDVLQE SSSVLKDEEI
1360 1370 1380 1390 1400
ELAVNEVVQG VLNNEKKTQS QDNKDNKEQP GEQDVNVSLL NSKNLLNNNN
1410 1420 1430 1440 1450
NNNNNSPSPT PTTATATAET EAETEVNANE IVSSTEAPKA ETETSVAPEV
1460 1470 1480 1490 1500
ETPETAKPSP IVPSPVLATN QKTEDAANKL NNNEKLAEIS ASPEPPIVVE
1510 1520 1530 1540 1550
TPEADLLQLS DSETKPNKET EAEDSVALAV RDIVEQLIDK VIDATEAESA
1560 1570 1580 1590 1600
SETKTETNNN EIPKKEKQTS EEPEDVETAE TLAAAAKEIV QEVVEAALVM
1610 1620 1630 1640 1650
VQEESTQEKP EKGANSEEEK NEIGKEEILL QLEEKPASTE VQETKIEGDL
1660 1670 1680 1690 1700
KKPEDPKGHS SVEPKTPNLE EPKPQETEQQ KSQEVAEELP QKPEEQVVAI
1710 1720 1730 1740 1750
VNQVLDTLVD DTVKAVAAEQ TTQTSPAPEE QSPQILAMES PATSVRVKPT
1760 1770 1780 1790 1800
EVDSTTQTTP KNEAGSSLLV EQVQQVLQED DAQQSAGMTI EDEDYSNQQA
1810 1820 1830 1840 1850
AAAVENANSS QLDANHYGPG NPESKQQQQR SKSGSTRPMF SPGPTRPPFR
1860 1870 1880 1890 1900
IPEFKWSYIH QRLLSDVLFS LETDIQVWRS HSTKSVLDFV NSSENAIFVV
1910 1920 1930 1940 1950
NTVHLISQLA DNLIIACGGL LPLLASATSP NSELDVLEPT QGMPLEVAVS
1960 1970 1980 1990 2000
FLQRLVNMAD VLIFATSLNF GELEAEKNMS SGGILRQCLR LVCTCAVRNC
2010 2020 2030 2040 2050
LECKERTRYN VGALARDVPG AAHLQALIRG AQASPKNIVE SITGQLSPVK
2060 2070 2080 2090 2100
DPEKLLQDMD VNRLRAVIYR DVEETKQAQF LSLAIVYFIS VLMVSKYRDI
2110 2120 2130 2140 2150
LEPPAEPQIQ RQSPVLQRTA GGGGRQIQDS DYEIIVVDEN NPSVLADNDS
2160 2170 2180 2190 2200
HSSGPPSIKA NQTTTIATTT TTTATTHINN NNTKTTTSNA PTATIKIQQQ
2210 2220 2230 2240 2250
PLSPPKPLVP QKLPKSVDSD VGSLNMNSTE NEVPEVESSS EILIDDHKPS
2260 2270 2280 2290 2300
HSNDESWTDV NLNEDAAVQA ASAGIVVGLV DNRGNVISDK HDPSHHNQQQ
2310 2320 2330 2340 2350
QQQAGIIGQQ QQHGSLGHSE RGDKPDSEIS VVRVPDGYGG AGSGGGVNSG
2360 2370 2380 2390 2400
QGQGVPSNQR PRPEELPMKA PALVAQLPLT TPSREASLTQ KLEIALGPVC
2410 2420 2430 2440 2450
PLLREIMVDF APFLSKTLVG SHGQELLMEG KGLTTFKNSH SVVELVMLLC
2460 2470 2480 2490 2500
SQEWQNSLQK HAGLAFIELI NEGRLLSHAM KDHIVRVANE AEFILNRMRA
2510 2520 2530 2540 2550
DDVLKHADFE SQCAQTLLER REEERMCDHL ITAARRRDNV IASRLLEKVR
2560 2570 2580 2590 2600
NIMCNRHGAW GDSSSTSSGG AIVGAVQKSP YWKLDAWEDD ARRRKRMVQN
2610 2620 2630 2640 2650
PRGSSHPQAT LKAALENGGP EDAILQTRDE FHTQIAVSRT HPSGQHNGEL
2660 2670 2680 2690 2700
LDDAELLIED RELDLDLTGP VNISTKARLI APGLVAPGTV SITSTEMFFE
2710 2720 2730 2740 2750
VDEEHPEFQK IDGEVLKYCD HLHGKWYFSE VRAIFSRRYL LQNVALEIFL
2760 2770 2780 2790 2800
ASRTSILFAF PDQHTVKKVI KALPRVGVGI KYGIPQTRRA SMMSPRQLMR
2810 2820 2830 2840 2850
NSNMTQKWQR REISNFEYLM FLNTIAGRTY NDLNQYPIFP WVLTNYESKD
2860 2870 2880 2890 2900
LDLSLPSNYR DLSKPIGALN PSRRAYFEER YESWDSDTIP PFHYGTHYST
2910 2920 2930 2940 2950
AAFTLNWLVR VEPFTTMFLA LQGGKFDYPD RLFSSVSLSW KNCQRDTSDV
2960 2970 2980 2990 3000
KELIPEWYFL PEMFYNSSGY RLGHREDGAL VDDIELPPWA KSPEEFVRIN
3010 3020 3030 3040 3050
RMALESEFVS CQLHQWIDLI FGYKQRGPEA IRATNVFYYL TYEGSVDLDG
3060 3070 3080 3090 3100
VLDPVMREAV ENQIRNFGQT PSQLLMEPHP PRSSAMHLSP MMFSAMPEDL
3110 3120 3130 3140 3150
CQMLKFYQNS PVIHISANTY PQLSLPSVVT VTAGHQFAVN RWNCNYTASV
3160 3170 3180 3190 3200
QSPSYAESPQ SPGSNQPLTI DPVLAVHGTN NNSNAASRRH LGDNFSQMLK
3210 3220 3230 3240 3250
IRSNCFVTTV DSRFLIACGF WDNSFRVFAT ETAKIVQIVF GHFGVVTCMA
3260 3270 3280 3290 3300
RSECNITSDC YIASGSADCT VLLWHWNART QSIVGEGDVP TPRATLTGHE
3310 3320 3330 3340 3350
QAVTSVVISA ELGLVVSGSS NGPVLIHTTF GDLLRSLDPP AEFHSPELIT
3360 3370 3380 3390 3400
MSREGFIVIN YDKGNVAAYT INGKKLRHET HNDNLQCMLL SRDGEYLMTA
3410 3420 3430 3440 3450
GDRGIVEVWR TFNLAPLYAF PACNAGIRSL ALTHDQKYLL AGLSTGSIIV
3460
FHIDFNRWHH EYQQRY
Length:3,466
Mass (Da):384,513
Last modified:March 16, 2016 - v4
Checksum:i152AEB5152C8F37C
GO
Isoform RImported (identifier: Q9W4E2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-53: ADIMRPPYSE...REVVNTVLHL → DSLERLMRAA...QCLVFLKAFS
     388-594: Missing.
     759-768: Missing.
     2159-2214: Missing.

Show »
Length:3,239
Mass (Da):361,045
Checksum:iE8B0215DAAF39BB1
GO

Sequence cautioni

The sequence AAB83959 differs from that shown.Intron retention. In addition to the intron retained at the N-terminus, there are other discrepancies towards the C-terminus.Curated
The sequence AAK93020 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAC18799 differs from that shown.Intron retention. In addition, there are retained or missing exons which cannot be reconciled with any described isoform.Curated
The sequence CAC18800 differs from that shown.Intron retention. In addition, there are retained or missing exons which cannot be reconciled with any described isoform.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181F → C in CAC18799 (PubMed:11102458).Curated
Sequence conflicti218 – 2181F → C in CAC18800 (PubMed:11102458).Curated
Sequence conflicti218 – 2181F → C in AAB83959 (PubMed:9334242).Curated
Sequence conflicti237 – 2371C → S in CAC18799 (PubMed:11102458).Curated
Sequence conflicti237 – 2371C → S in CAC18800 (PubMed:11102458).Curated
Sequence conflicti237 – 2371C → S in AAB83959 (PubMed:9334242).Curated
Sequence conflicti411 – 4111T → A in CAC18799 (PubMed:11102458).Curated
Sequence conflicti411 – 4111T → A in AAB83959 (PubMed:9334242).Curated
Sequence conflicti415 – 4151T → S in CAC18799 (PubMed:11102458).Curated
Sequence conflicti415 – 4151T → S in AAB83959 (PubMed:9334242).Curated
Sequence conflicti552 – 5521H → D in CAC18799 (PubMed:11102458).Curated
Sequence conflicti552 – 5521H → D in AAB83959 (PubMed:9334242).Curated
Sequence conflicti590 – 5901N → D in CAC18799 (PubMed:11102458).Curated
Sequence conflicti590 – 5901N → D in AAB83959 (PubMed:9334242).Curated
Sequence conflicti1702 – 17021N → T in CAC18799 (PubMed:11102458).Curated
Sequence conflicti1702 – 17021N → T in CAC18800 (PubMed:11102458).Curated
Sequence conflicti1702 – 17021N → T in AAB83959 (PubMed:9334242).Curated
Sequence conflicti2230 – 223910ENEVPEVESS → GKTKCPRWSHP in CAC18799 (PubMed:11102458).Curated
Sequence conflicti2230 – 223910ENEVPEVESS → GKTKCPRWSHP in CAC18800 (PubMed:11102458).Curated
Sequence conflicti2230 – 223910ENEVPEVESS → GKTKCPRWSHP in AAB83959 (PubMed:9334242).Curated
Sequence conflicti2576 – 25761V → G in CAC18799 (PubMed:11102458).Curated
Sequence conflicti2576 – 25761V → G in CAC18800 (PubMed:11102458).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 5352ADIMR…TVLHL → DSLERLMRAAPLPRMLTSGV VATAAAAASAAAGKGMVSVG GGATAIAAGGGQQRALVHAS LAAATVGRKGRHLTGTFCLT GDTMEGIIQCLVFLKAFS in isoform R. VSP_058161Add
BLAST
Alternative sequencei388 – 594207Missing in isoform R. VSP_058162Add
BLAST
Alternative sequencei759 – 76810Missing in isoform R. VSP_058163
Alternative sequencei2159 – 221456Missing in isoform R. VSP_058164Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46011.4.
AE014298 Genomic DNA. Translation: AAN09135.1.
Y18278 mRNA. Translation: CAC18799.1. Sequence problems.
Y18278 mRNA. Translation: CAC18800.1. Sequence problems.
AF003622 mRNA. Translation: AAB83959.1. Sequence problems.
AY051596 mRNA. Translation: AAK93020.1. Different initiation.
PIRiT03094.
RefSeqiNP_001138158.2. NM_001144686.2. [Q9W4E2-5]
NP_726978.2. NM_167028.3. [Q9W4E2-6]

Genome annotation databases

GeneIDi44531.
KEGGidme:Dmel_CG44835.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46011.4.
AE014298 Genomic DNA. Translation: AAN09135.1.
Y18278 mRNA. Translation: CAC18799.1. Sequence problems.
Y18278 mRNA. Translation: CAC18800.1. Sequence problems.
AF003622 mRNA. Translation: AAB83959.1. Sequence problems.
AY051596 mRNA. Translation: AAK93020.1. Different initiation.
PIRiT03094.
RefSeqiNP_001138158.2. NM_001144686.2. [Q9W4E2-5]
NP_726978.2. NM_167028.3. [Q9W4E2-6]

3D structure databases

ProteinModelPortaliQ9W4E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69112. 12 interactions.
DIPiDIP-17945N.
IntActiQ9W4E2. 2 interactions.
STRINGi7227.FBpp0288527.

Proteomic databases

PaxDbiQ9W4E2.
PRIDEiQ9W4E2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi44531.
KEGGidme:Dmel_CG44835.

Organism-specific databases

CTDi44531.
FlyBaseiFBgn0266098. rg.

Phylogenomic databases

eggNOGiKOG1787. Eukaryota.
ENOG410XNQC. LUCA.
InParanoidiQ9W4E2.
OrthoDBiEOG091G024D.

Enzyme and pathway databases

SignaLinkiQ9W4E2.

Miscellaneous databases

GenomeRNAii44531.
PROiQ9W4E2.

Gene expression databases

BgeeiFBgn0086911.
GenevisibleiQ9W4E2. DM.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 2 hits.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNBEA_DROME
AccessioniPrimary (citable) accession number: Q9W4E2
Secondary accession number(s): O16024
, Q8IRR9, Q961G8, Q9GP69, Q9GP70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 16, 2016
Last modified: September 7, 2016
This is version 143 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.