Unreviewed, UniProtKB/TrEMBL Q9W4C3 (Q9W4C3_DROME)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435V0
    EC=3.1.2.15

Gene names

ORF Names:

CG4165 FlyBase FBgn0029763, Dmel_CG4165 EMBL AAF46033.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1126 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. RuleBase RU004435V0
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434V0

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434V0
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434V0
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9W4C3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E57A10AF0A5E5849	FASTA	1,126	121,487
	10 20 30 40 50 60 MVKKRQADSR DHDCSTDSGN EDLHHRKGLG SPGQSDGATP TTASCQHIKK AVDAARLRRL 70 80 90 100 110 120 LKSTGLLYEC SQCQKLGKTA GSAAGAGASE GAVGPGGNPV TFEFDNTLWL CLKCGSQLCG 130 140 150 160 170 180 RARHKHALEH YQTPHSDSHA LAMNTRSFDI WCYECDMKIC SNLRKNLLEC VELVKKLAQK 190 200 210 220 230 240 PPTSTVTPST PTISYIEEKL KAALEHLTPI VPMTGGSFDD SSSRGSLAAA GGGGGVGSSR 250 260 270 280 290 300 NRQVAIPMPP PEPSSGLSTS DSLTSVPGMA KRIDQYSATT NGNTGNKRLL TLETPRIENE 310 320 330 340 350 360 RLPRVRGLTN LGNTCFFNAV MQCLAQTPFL LSVLKELSEP GEEFILPGGT FTIKDKGDIE 370 380 390 400 410 420 LPMIKGTLSS WGGLTAALAN ALEELQAGGS VFTPRKLFDR LCVKCPQFTG GDQHDAHELL 430 440 450 460 470 480 RQLLESVRNE DLKRYQRVIL QNLGYKDQDV NSVSEEMRQK CKIYGNQAGD RILRPEQVFR 490 500 510 520 530 540 GFLVSTLTCQ DCHNVSSRHE YFLDMSLPVA VEKPQPPQRR KPSPELSLTS SSSSVTPSTG 550 560 570 580 590 600 QPTINTKFTD GSVNFTASSP SFFLHAHEAA SLGPSKSQVK KEKERQRKAK RAAKKRQKSS 610 620 630 640 650 660 LNLNGNDSGN GNELAESVDQ DDASLASLGA GDGQANDGLE QTNGQTEDST TSSVTTSEHS 670 680 690 700 710 720 DADVEDNLVE DTAAPSTNNV PSSTASLTAP SKTYMDSNGN AQPPGEKRDD TPEHMDKDSL 730 740 750 760 770 780 EEDENDSGIA TSPAPTATNS STSTSATGNN NSVAGSGLSG SSGALEDPLA PASLVTAGLS 790 800 810 820 830 840 EKGASVIRQV SVGAEQGASN GTEDADGEAK AIEQPEKTPS QAQAMAQAQA RTKRVRTQSY 850 860 870 880 890 900 SDWSTTIAPR YQCEDGECSV QSCLNNFTAV ELMTGQNKVG CDSCTQRING SDPKAKSVNT 910 920 930 940 950 960 NATKQLLVSS PPAVLILHLK RFQLGPRCIF RKLTRPVSYP NLLDIAAFCG SKVKNLPNID 970 980 990 1000 1010 1020 RKQKKLLYAL YGVVEHSGGM YGGHYTAYVK VRPKVAPGDK RWKFLPHGSK AELDQDDDQL 1030 1040 1050 1060 1070 1080 KKLEELLAKE KAREQHLKVL DDSDDFSNSS SNSSTSDESQ TPATPLEEQQ TQQAQQPQQP 1090 1100 1110 1120 QQLEEAANVR APPGKWYYVS DSRVQEVSED TALKAQAYLL FYERIY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAK93270.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014298 Genomic DNA. Translation: AAF46033.1. AY051846 mRNA. Translation: AAK93270.1. AE014298 Genomic DNA. Translation: AAN09140.1. AE014298 Genomic DNA. Translation: AAN09141.1. AE014298 Genomic DNA. Translation: AAN09142.1.
RefSeq	NP_572220.1. NP_726993.1. NP_726994.1. NP_726995.1.
UniGene	Dm.7220
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9W4C3. 3 interactions.
Proteomic databases
PRIDE	Q9W4C3.
Genome annotation databases
Ensembl	FBgn0029763. Drosophila melanogaster. [Contig view]
GeneID	31458.
KEGG	dme:Dmel_CG4165.
Organism-specific databases
FlyBase	FBgn0029763. CG4165.
Phylogenomic databases
HOGENOM	Q9W4C3.
OMA	Q9W4C3. AVELMTG.
Gene expression databases
ArrayExpress	Q9W4C3.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR001607. Znf_UBP. [Graphical view]
Pfam	PF00443. UCH. 1 hit. PF02148. zf-UBP. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS50271. ZF_UBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	773741.

Entry information

Entry name

Q9W4C3_DROME

Accession

Primary (citable) accession number: Q9W4C3

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)