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Q9W4C3 (Q9W4C3_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435
EC=3.4.19.12 RuleBase RU004435
Gene names
ORF Names:CG4165 EMBL AAK93270.1 FlyBase FBgn0029763, Dmel_CG4165 EMBL AAF46033.1
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length1126 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SAAS SAAS018200 RuleBase RU004435

Sequence similarities

Belongs to the peptidase C19 family. RuleBase RU004434

Contains 1 UBP-type zinc finger. SAAS SAAS001394

Sequences

Sequence LengthMass (Da)Tools
Q9W4C3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E57A10AF0A5E5849

FASTA1,126121,487
        10         20         30         40         50         60 
MVKKRQADSR DHDCSTDSGN EDLHHRKGLG SPGQSDGATP TTASCQHIKK AVDAARLRRL 

        70         80         90        100        110        120 
LKSTGLLYEC SQCQKLGKTA GSAAGAGASE GAVGPGGNPV TFEFDNTLWL CLKCGSQLCG 

       130        140        150        160        170        180 
RARHKHALEH YQTPHSDSHA LAMNTRSFDI WCYECDMKIC SNLRKNLLEC VELVKKLAQK 

       190        200        210        220        230        240 
PPTSTVTPST PTISYIEEKL KAALEHLTPI VPMTGGSFDD SSSRGSLAAA GGGGGVGSSR 

       250        260        270        280        290        300 
NRQVAIPMPP PEPSSGLSTS DSLTSVPGMA KRIDQYSATT NGNTGNKRLL TLETPRIENE 

       310        320        330        340        350        360 
RLPRVRGLTN LGNTCFFNAV MQCLAQTPFL LSVLKELSEP GEEFILPGGT FTIKDKGDIE 

       370        380        390        400        410        420 
LPMIKGTLSS WGGLTAALAN ALEELQAGGS VFTPRKLFDR LCVKCPQFTG GDQHDAHELL 

       430        440        450        460        470        480 
RQLLESVRNE DLKRYQRVIL QNLGYKDQDV NSVSEEMRQK CKIYGNQAGD RILRPEQVFR 

       490        500        510        520        530        540 
GFLVSTLTCQ DCHNVSSRHE YFLDMSLPVA VEKPQPPQRR KPSPELSLTS SSSSVTPSTG 

       550        560        570        580        590        600 
QPTINTKFTD GSVNFTASSP SFFLHAHEAA SLGPSKSQVK KEKERQRKAK RAAKKRQKSS 

       610        620        630        640        650        660 
LNLNGNDSGN GNELAESVDQ DDASLASLGA GDGQANDGLE QTNGQTEDST TSSVTTSEHS 

       670        680        690        700        710        720 
DADVEDNLVE DTAAPSTNNV PSSTASLTAP SKTYMDSNGN AQPPGEKRDD TPEHMDKDSL 

       730        740        750        760        770        780 
EEDENDSGIA TSPAPTATNS STSTSATGNN NSVAGSGLSG SSGALEDPLA PASLVTAGLS 

       790        800        810        820        830        840 
EKGASVIRQV SVGAEQGASN GTEDADGEAK AIEQPEKTPS QAQAMAQAQA RTKRVRTQSY 

       850        860        870        880        890        900 
SDWSTTIAPR YQCEDGECSV QSCLNNFTAV ELMTGQNKVG CDSCTQRING SDPKAKSVNT 

       910        920        930        940        950        960 
NATKQLLVSS PPAVLILHLK RFQLGPRCIF RKLTRPVSYP NLLDIAAFCG SKVKNLPNID 

       970        980        990       1000       1010       1020 
RKQKKLLYAL YGVVEHSGGM YGGHYTAYVK VRPKVAPGDK RWKFLPHGSK AELDQDDDQL 

      1030       1040       1050       1060       1070       1080 
KKLEELLAKE KAREQHLKVL DDSDDFSNSS SNSSTSDESQ TPATPLEEQQ TQQAQQPQQP 

      1090       1100       1110       1120 
QQLEEAANVR APPGKWYYVS DSRVQEVSED TALKAQAYLL FYERIY

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley.
[3]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. expand/collapse author list , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley EMBL AAK93270.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014298 Genomic DNA. Translation: AAF46033.1.
AY051846 mRNA. Translation: AAK93270.1.
AE014298 Genomic DNA. Translation: AAN09140.1.
AE014298 Genomic DNA. Translation: AAN09141.1.
AE014298 Genomic DNA. Translation: AAN09142.1.
RefSeqNP_572220.1. NM_131992.2.
NP_726993.1. NM_167035.1.
NP_726994.1. NM_167036.1.
NP_726995.1. NM_167037.1.
UniGeneDm.7220.

3D structure databases

ProteinModelPortalQ9W4C3.
SMRQ9W4C3. Positions 43-178.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-901982.

Proteomic databases

PRIDEQ9W4C3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0070772; FBpp0070738; FBgn0029763.
FBtr0070773; FBpp0070739; FBgn0029763.
FBtr0070774; FBpp0070740; FBgn0029763.
FBtr0070775; FBpp0070741; FBgn0029763.
GeneID31458.
KEGGdme:Dmel_CG4165.
UCSCCG4165-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0029763. CG4165.

Phylogenomic databases

eggNOGinNOG08991.
GeneTreeEMGT00050000004707.
InParanoidQ9W4C3.
OMAASTIICH.
OrthoDBEOG476HF7.
PhylomeDBQ9W4C3.

Gene expression databases

ArrayExpressQ9W4C3.
BgeeQ9W4C3.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KOK11844.
PfamPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio773741.

Entry information

Entry nameQ9W4C3_DROME
AccessionPrimary (citable) accession number: Q9W4C3
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info