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Protein
Submitted name:

Ca[2+]-channel protein alpha[[1]] subunit T, isoform B

Gene

Ca-alpha1T

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium channel activity Source: FlyBase
  • low voltage-gated calcium channel activity Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ca[2+]-channel protein alpha[[1]] subunit T, isoform BImported
Gene namesi
Name:Ca-alpha1TImported
ORF Names:CG15899Imported, Dmel_CG15899Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0264386. Ca-alpha1T.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei430 – 45324HelicalSequence analysisAdd
BLAST
Transmembranei552 – 57019HelicalSequence analysisAdd
BLAST
Transmembranei590 – 61526HelicalSequence analysisAdd
BLAST
Transmembranei1232 – 125019HelicalSequence analysisAdd
BLAST
Transmembranei1262 – 128322HelicalSequence analysisAdd
BLAST
Transmembranei1295 – 131521HelicalSequence analysisAdd
BLAST
Transmembranei1361 – 138424HelicalSequence analysisAdd
BLAST
Transmembranei1437 – 146024HelicalSequence analysisAdd
BLAST
Transmembranei2177 – 220529HelicalSequence analysisAdd
BLAST
Transmembranei2284 – 230320HelicalSequence analysisAdd
BLAST
Transmembranei2384 – 240724HelicalSequence analysisAdd
BLAST
Transmembranei2464 – 248522HelicalSequence analysisAdd
BLAST
Transmembranei2497 – 251923HelicalSequence analysisAdd
BLAST
Transmembranei2600 – 262021HelicalSequence analysisAdd
BLAST
Transmembranei2685 – 271127HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9W433.
PRIDEiQ9W433.

Expressioni

Gene expression databases

BgeeiQ9W433.
GenevisibleiQ9W433. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9W433. 5 interactions.
MINTiMINT-871756.
STRINGi7227.FBpp0111866.

Structurei

3D structure databases

ProteinModelPortaliQ9W433.
SMRiQ9W433. Positions 303-456, 554-631, 1233-1477, 2139-2408, 2456-2709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 622323Ion_transInterPro annotationAdd
BLAST
Domaini1230 – 1469240Ion_transInterPro annotationAdd
BLAST
Domaini2145 – 2417273Ion_transInterPro annotationAdd
BLAST
Domaini2463 – 2720258Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2030 – 205728Sequence analysisAdd
BLAST
Coiled coili2711 – 273424Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

Q9W433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPQPAAAVA TATTTTTQSA TSATSTAATS AAAAAARNGQ RRRVAAATEG
60 70 80 90 100
CNSNIGNSNS KLSSNTTTNT TKRVSQMHSN EEPPMTVIVD GGGGSNVSVS
110 120 130 140 150
GGSSHRRGSQ RLRKTSSSSA NAKSASANPT ERTSSGQRSS HRQTSNASDG
160 170 180 190 200
GGSSRRRYQG KEHHDRRDRQ DRQDRQDRQE RSDRHERRDR RDEQQAARRR
210 220 230 240 250
TGRRHSGASS LSDAAAATAA GRSRSRGGGR TGGAVSSSTG SSCNGSCSSD
260 270 280 290 300
DGDSSHTSSS SSSSSSGEPN LPYPGFPEIS IRALTQYTRP RNWCLMLITN
310 320 330 340 350
PWFERVSILV ILLNCITLGM YQPCVDDACV TNRCKILQIF DDIIFAFFAL
360 370 380 390 400
EMTIKMVAMG ICGKNTYLAD SWNRLDFFIV LAGLLEYVMH VENLNLTAIR
410 420 430 440 450
TIRVLRPLRA INRIPSMRIL VMLLLDTLPM LGNVLLLCFF VFFIFGIIGV
460 470 480 490 500
QLWEGILRQR CSLMRTEGMV YPLTLSQYYE FSKDQDYICS TPNDSGMHLC
510 520 530 540 550
GNFPPYRIGS LVCNEEAKLF DFNEPTNTSC VNWNQYYTTC KQSGENPFQG
560 570 580 590 600
TISFDNIGMA WVAIFLVISL EGWTDIMYYV QDAHSFWDWI YFVLLIVIGS
610 620 630 640 650
FFMINLCLVV IATQFSETKK REMERMRQER ARYTSTSTLA SSTNNSEPAT
660 670 680 690 700
CYAEIVKYIA HLWRRFKRRM LKKYRLYKYQ RQQRKEGLLP NADNLTFSPS
710 720 730 740 750
RIKCHHPKCP KYSNRKPSSI QDQMITVMVP LNSASNNINN NNNNNSNSSN
760 770 780 790 800
HNGSGNHTAA GGGNNNNNNN NNNAASCTTV ALVNGINGSA ASVTMSSAHH
810 820 830 840 850
QQHQLLQHQQ QQHQNQQQQQ QQQQHSSSDN TEQSLAPDGL PRSSSLKKST
860 870 880 890 900
AHHQLKPEGS AAEQKTILLK FPQQMIDSEQ LILQLGNLGK SHPCTSGFLS
910 920 930 940 950
PPTSASRRPS VMFNEYVLLH TPPALNADPA TAGTTTTVAP TVATVAGTAA
960 970 980 990 1000
AAAAAAATGS GSGNNNHQNG GASGGAGTGG TTEKSNIFST EKMTQAGDGS
1010 1020 1030 1040 1050
IWQVNLPQTI GTIANPYADC SELGIHDAMT CQELLAFSVA FSAALPTGQS
1060 1070 1080 1090 1100
TLESFYTSLA RCDPHTAEAL RAHHKPRSVP TGQNQTTPGA EGATVMVAST
1110 1120 1130 1140 1150
AGDTGQTLQP STVSAVVGGT IDSHAANHRR KEHHQQSHHH HNNNNTTSHS
1160 1170 1180 1190 1200
RNYRSRQGQG NSRMREPRAP TGNYMEDYAC CYDLYQNALS PLDERPRQRS
1210 1220 1230 1240 1250
PTTRCLISVY RCMSRVCSWI RRYIRRLVEH KYFQQGILLA ILINTLSMGI
1260 1270 1280 1290 1300
EYHNQPPELT AIVETSNVVF SGIFAVEMLL KVVAEGPFRY IANGFNVFDG
1310 1320 1330 1340 1350
IIVILSAIEI CQTFMGNGTG GGGSGLSVLR TFRLLRILKL VRFMPNLRRQ
1360 1370 1380 1390 1400
LFVMLRTMDN VAVFFSLLVL FIFIFSILGM NLFGCKFCEK VNGEMICDRK
1410 1420 1430 1440 1450
NFDSLLWALV TVFQILTQED WNVVLFNGME KTSHWAALYF VALMTFGNYV
1460 1470 1480 1490 1500
LFNLLVAILV EGFSSERNER REREQRELVK KLREETLAEN YSDGMYDESR
1510 1520 1530 1540 1550
SEADSSTTND SYYEVRNRWR SAEDVRKLQD SVELIIEAKS NMHRQRLLQP
1560 1570 1580 1590 1600
THDYQINELP ASSAAPSASG TSGASAPGDR ERDRDRDRDR ERDRDRDRER
1610 1620 1630 1640 1650
DREAGGGGKE EGAQHAKPRG GLKKTYSIKE RRSEAPRLSK IRLARDPPII
1660 1670 1680 1690 1700
TTTAATPQDS PSTTLEPGMS FRQWGDMEPP SPPSPSLLRP PNIFTGGQRS
1710 1720 1730 1740 1750
LDEGIPSIDL IPPSPVLSHK PLNILNASQL GVGMGGGVPS TAGSSSSMHS
1760 1770 1780 1790 1800
VIIDDISKSS SSTAAATPIY VPTISSTADA QSQSHSLNDV SVGSSPGGEI
1810 1820 1830 1840 1850
PATGMSRNAN TGASTSGSSS SERLPLAPPP QQGSFKQRLR RGSSKKRRAS
1860 1870 1880 1890 1900
ALALATDDNP ARRTLDNQAR RTQDEEEEQQ QLNNGGDNSC LLRNSNAVVS
1910 1920 1930 1940 1950
GSSSGTKETN RLSPQNSIRR LSNTLSIGSG PVGSRRASAC IFNSQVYQNL
1960 1970 1980 1990 2000
NQPPKLRPGS GQRRMSSIEL AFSKTSHLNL HNLEANRKSL SYTNSKMDLD
2010 2020 2030 2040 2050
KWNKSYGNLN EPDNMLQQYM EARDKRKNSI SHYNLKKRLE EKELQQLQQL
2060 2070 2080 2090 2100
HQQQLLQQRQ DSFSSTTQQQ QQQLQQHRLS KDQQQLAMQP HSMVPGGGER
2110 2120 2130 2140 2150
YSKLKMLIEQ LTPKHFTTER EDYSLYIFPE DNRFRQICTW FVNQKWFDNV
2160 2170 2180 2190 2200
VLLFIALNCI TLAMERPNIP PSSTERLFLA TANYVFTVVF TVEMFIKVVA
2210 2220 2230 2240 2250
TGMFYGHDAY FTSGWNIMDG SLVTISIIDL LMSLISESSP RIFGILRVFR
2260 2270 2280 2290 2300
LLRSLRPLRV INRAPGLKLV VQTLLSSLRP IGNIVLICCT FFIIFGILGV
2310 2320 2330 2340 2350
QLFKGTFYYC EGENIKGVRN ADECRRIPGN VWTNRKYNFD DLGKALMSLF
2360 2370 2380 2390 2400
VLSSRDGWVN IMYTGLDAVG VDQQPIVNYN EWRLLYFIAF ILLVGFFVLN
2410 2420 2430 2440 2450
MFVGVVVENF HRCREEQEKE EKIRRAAKRA LQMEKKRRRM HEPPYYTNYS
2460 2470 2480 2490 2500
PTRMFVHNVV TSKYFDLAIA AVIGLNVVTM AMEYYKMPSG LKYALKIFNY
2510 2520 2530 2540 2550
FFTAVFILEA NMKLVALGWK LYLKDRWNQL DVGIVLLSIV GIVLEELETN
2560 2570 2580 2590 2600
THQIIPINPT IIRVMRVLRI ARVLKLLKMA NGIRALLDTV MQALPQVGNL
2610 2620 2630 2640 2650
GLLFFLLFFI FAALGVELFG RLECSDEIPC QGLGEHAHFA NFGMAFLTLF
2660 2670 2680 2690 2700
RVATGDNWNG IMKDTLRDNC DDAADCVRNC CVSSVIAPIF FVIFVLMAQF
2710 2720 2730 2740 2750
VLVNVVVAVL MKHLEESHKQ MEDELDMEVE LERELVREQE FAQEQKLCQQ
2760 2770 2780 2790 2800
LAEAQSKAAA PPRPLAKVKS LPKNFIYSTP SLDKKFPAVS GVNNPSLTSS
2810 2820 2830 2840 2850
AATNLNQVAT AGSGGAAPGA VPAGSGAGPR RQTVQYFQQP PQSMLGGLSL
2860 2870 2880 2890 2900
AEMGGTLTPQ ALGARLGEPF GGGGGNKSGP RRQSYWQINP IRKRGVLSKE
2910 2920 2930 2940 2950
RSLDEQAIRR RNLEAKRTSC DSLPWGGDAL DCRRGTIFES LESDGGGVGG
2960 2970 2980 2990 3000
GGSGGGGGGL GGGVSYDLRS VRSADVGHSE MDGDVSLSVV SALVPSVTTP
3010 3020 3030 3040 3050
LPPPLSLPIV TPTSTPTPLQ LPMPMPMPMA HPPPRRPFGW SQSVDQGCLR
3060 3070 3080 3090 3100
SNLLLSVPRS MPPRSRSGST KQLFKQQALD EDADMDENSL LLPTAAGGGS
3110 3120 3130 3140 3150
GPGSVAVIAS SSLDLPDQSG SSKQILPDIA LGVSKSDSSD ILRIISERRR
3160 3170 3180
MDQREQREPE QDQDNEAEDR DSDYKELLLV KSPQSSMD
Length:3,188
Mass (Da):352,166
Last modified:December 4, 2007 - v3
Checksum:i35540C6198B1A549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46127.3.
RefSeqiNP_572296.2. NM_132068.3.
UniGeneiDm.13928.

Genome annotation databases

EnsemblMetazoaiFBtr0089393; FBpp0088415; FBgn0264386.
GeneIDi31550.
UCSCiCG15899-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46127.3.
RefSeqiNP_572296.2. NM_132068.3.
UniGeneiDm.13928.

3D structure databases

ProteinModelPortaliQ9W433.
SMRiQ9W433. Positions 303-456, 554-631, 1233-1477, 2139-2408, 2456-2709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9W433. 5 interactions.
MINTiMINT-871756.
STRINGi7227.FBpp0111866.

Proteomic databases

PaxDbiQ9W433.
PRIDEiQ9W433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089393; FBpp0088415; FBgn0264386.
GeneIDi31550.
UCSCiCG15899-RB. d. melanogaster.

Organism-specific databases

CTDi31550.
FlyBaseiFBgn0264386. Ca-alpha1T.

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128242.

Miscellaneous databases

GenomeRNAii31550.

Gene expression databases

BgeeiQ9W433.
GenevisibleiQ9W433. DM.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR01629. TVDCCALPHA1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.

Entry informationi

Entry nameiQ9W433_DROME
AccessioniPrimary (citable) accession number: Q9W433
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: December 4, 2007
Last modified: June 8, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.