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Q9W422

- JOSL_DROME

UniProt

Q9W422 - JOSL_DROME

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Protein

Josephin-like protein

Gene

CG3781

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a deubiquitinating enzyme.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491NucleophilePROSITE-ProRule annotation
Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. omega peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC86.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Josephin-like protein (EC:3.4.19.12)
Gene namesi
ORF Names:CG3781
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0029853. CG3781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Josephin-like proteinPRO_0000053845Add
BLAST

Proteomic databases

PaxDbiQ9W422.
PRIDEiQ9W422.

Expressioni

Gene expression databases

BgeeiQ9W422.
ExpressionAtlasiQ9W422. differential.

Interactioni

Protein-protein interaction databases

BioGridi58051. 1 interaction.
DIPiDIP-23119N.
MINTiMINT-966633.

Structurei

3D structure databases

ProteinModelPortaliQ9W422.
SMRiQ9W422. Positions 39-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 214179JosephinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Josephin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG321724.
GeneTreeiENSGT00390000009228.
InParanoidiQ9W422.
KOiK15235.
OMAiREVGGTY.
OrthoDBiEOG75B871.
PhylomeDBiQ9W422.

Family and domain databases

InterProiIPR006155. Josephin.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W422-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESPSARTLG NSLGDDSGNG NENGNGSGNG NTTMMPHGIY HERQTRHLCG
60 70 80 90 100
LHALNNLFQG PDMFSKSELD DYCTTLTPRN WLNPHRSWIG WGNYDVNVIM
110 120 130 140 150
YALQQRNCEA VWFDRRRDPH CLNLSVIFGF ILNVPAQMSL GYYIPLPFHM
160 170 180 190 200
RHWLALRRLN GSYYNLDSKL REPKCLGTEQ QFLEFLATQL QMDHELFLVL
210 220
DEETDCKDKS QQRWLLPQFR D
Length:221
Mass (Da):25,656
Last modified:March 1, 2003 - v3
Checksum:i17202EB46E97EFAB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431R → L in AAL48447. (PubMed:12537569)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46138.3.
AY070825 mRNA. Translation: AAL48447.2.
RefSeqiNP_572303.4. NM_132075.4.
UniGeneiDm.5285.

Genome annotation databases

EnsemblMetazoaiFBtr0070895; FBpp0070860; FBgn0029853.
GeneIDi31560.
KEGGidme:Dmel_CG3781.
UCSCiCG3781-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46138.3 .
AY070825 mRNA. Translation: AAL48447.2 .
RefSeqi NP_572303.4. NM_132075.4.
UniGenei Dm.5285.

3D structure databases

ProteinModelPortali Q9W422.
SMRi Q9W422. Positions 39-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 58051. 1 interaction.
DIPi DIP-23119N.
MINTi MINT-966633.

Protein family/group databases

MEROPSi C86.005.

Proteomic databases

PaxDbi Q9W422.
PRIDEi Q9W422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0070895 ; FBpp0070860 ; FBgn0029853 .
GeneIDi 31560.
KEGGi dme:Dmel_CG3781.
UCSCi CG3781-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0029853. CG3781.

Phylogenomic databases

eggNOGi NOG321724.
GeneTreei ENSGT00390000009228.
InParanoidi Q9W422.
KOi K15235.
OMAi REVGGTY.
OrthoDBi EOG75B871.
PhylomeDBi Q9W422.

Miscellaneous databases

GenomeRNAii 31560.
NextBioi 774203.

Gene expression databases

Bgeei Q9W422.
ExpressionAtlasi Q9W422. differential.

Family and domain databases

InterProi IPR006155. Josephin.
[Graphical view ]
Pfami PF02099. Josephin. 1 hit.
[Graphical view ]
PROSITEi PS50957. JOSEPHIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-221.
    Strain: Berkeley.
    Tissue: Testis.
  4. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
    Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
    Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiJOSL_DROME
AccessioniPrimary (citable) accession number: Q9W422
Secondary accession number(s): Q8MTV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3