Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Regulatory particle triple-A ATPase 4

Gene

Rpt4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • ovarian follicle cell development Source: FlyBase
  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: GO_Central
  • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: FlyBase
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
  • ubiquitin-dependent ERAD pathway Source: GO_Central

Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 family signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-8948751. Regulation of PTEN stability and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Regulatory particle triple-A ATPase 4Imported (EC:3.-.-.-Imported, EC:3.6.1.3Imported)
Gene namesi
Name:Rpt4Imported
Synonyms:Dm_Rpt4aImported, Dm_Rpt4bImported, Dmel\CG3455Imported, Dmp42DImported, l(1)G0114Imported, l(1)G0227Imported, l(1)G0345Imported, p42DImported, S10bImported
ORF Names:CG3455Imported, Dmel_CG3455Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0028685. Rpt4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ9W414.
PeptideAtlasiQ9W414.
PRIDEiQ9W414.

Expressioni

Gene expression databases

BgeeiFBgn0028685.
ExpressionAtlasiQ9W414. differential.
GenevisibleiQ9W414. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9W414. 10 interactors.
MINTiMINT-1576647.
STRINGi7227.FBpp0293948.

Structurei

3D structure databases

ProteinModelPortaliQ9W414.
SMRiQ9W414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 313AAAInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 61Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0651. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074826.
InParanoidiQ9W414.
KOiK03064.
OMAiQPCVIFM.
OrthoDBiEOG091G096W.
PhylomeDBiQ9W414.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45-like.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR035263. PSMC6.
PANTHERiPTHR23073:SF59. PTHR23073:SF59. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9W414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTATPMPD NLRVKALSEY RKKLLEHKEI EGRLKEKREE IKDLTKLYDK
60 70 80 90 100
SENDLKALQS VGQIVGEVLK QLTEDKFIVK ATNGPRYVVG CRRQLDKAKL
110 120 130 140 150
KSGTRVALDM TTLTIMRYLP REVDPLVYNM SHEDPGDVTY SAIGGLTDQI
160 170 180 190 200
RELREVIELP LLNPELFLRV GITPPKGCLL YGPPGTGKTL LARAVASQLD
210 220 230 240 250
ANFLKVVSSA IVDKYIGESA RLIREMFNYA RDHQPCIIFM DEIDAIGGRR
260 270 280 290 300
FSEGTSADRE IQRTLMELLN QMDGFDSLGQ VKMIMATNRP DTLDPALLRP
310 320 330 340 350
GRLDRKIEIP LPNEQARLEI LKIHALKIAK HGEIDYEAIV KLSDNFNGAD
360 370 380 390
LRNVCTEAGL FAIRAEREYV IQEDFMKAVR KVSDNKKLES KLDYKPV
Length:397
Mass (Da):44,911
Last modified:June 26, 2013 - v3
Checksum:i14B04A81DC717AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46146.3.
RefSeqiNP_572308.3. NM_132080.4.

Genome annotation databases

EnsemblMetazoaiFBtr0305495; FBpp0293948; FBgn0028685.
GeneIDi31567.
KEGGidme:Dmel_CG3455.
UCSCiCG3455-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9W414_DROME
AccessioniPrimary (citable) accession number: Q9W414
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 26, 2013
Last modified: November 22, 2017
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported