Q9W3R7 (ATG5_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy protein 5

Alternative name(s):
APG5-like

Gene names

Name:	Atg5
ORF Names:	CG1643

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for autophagy. Ref.4
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Conjugated to ATG12; which is essential for autophagy By similarity.
Sequence similarities	Belongs to the ATG5 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	macroautophagy Inferred from mutant phenotype Ref.4. Source: FlyBase protein transport Inferred from electronic annotation. Source: UniProtKB-KW salivary gland cell autophagic cell death Inferred from expression pattern PubMed 12593804. Source: FlyBase
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Autophagy protein 5		PRO_0000218998
Amino acid modifications
	Cross-link	132		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9W3R7 [UniParc]. Last modified March 1, 2002. Version 2. Checksum: 92A3B132FC0146D8	FASTA	269	31,468
	10 20 30 40 50 60 MAHDREVLRM IWEGQIGICF QADRDEIVGI KPEPFYLMIS RLSYLPLVTD KVRKYFSRYI 70 80 90 100 110 120 SAEHQDGAVW FDFNGTPLRL HYPIGVLYDL LHPEEDSTPW CLTIHFSKFP EDMLVKLNSK 130 140 150 160 170 180 ELLESHYMSC LKEADVLKHR GLVISAMQKK DHNQLWLGLV NEKFDQFWAV NRRLMEPYGD 190 200 210 220 230 240 LESFKNIPLR IYTDDDFTYT QKLISPISVG GQKKSLADLM AELSTPVRRA VGCRTHGIDL 250 260 HEETQLQWMS EHLSYPDNFL HLSVDYKDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	"Role and regulation of starvation-induced autophagy in the Drosophila fat body." Scott R.C., Schuldiner O., Neufeld T.P. Dev. Cell 7:167-178(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF46252.2. AY069596 mRNA. Translation: AAL39741.1.
RefSeq	NP_572390.1. NM_132162.3.
UniGene	Dm.33486.
3D structure databases
ProteinModelPortal	Q9W3R7.
SMR	Q9W3R7. Positions 4-264.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-20667N.
IntAct	Q9W3R7. 1 interaction.
MINT	MINT-285488.
STRING	7227.FBpp0071023.
Proteomic databases
PaxDb	Q9W3R7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0071065; FBpp0071023; FBgn0029943.
GeneID	31666.
KEGG	dme:Dmel_CG1643.
Organism-specific databases
CTD	9474.
FlyBase	FBgn0029943. Atg5.
Phylogenomic databases
eggNOG	NOG271554.
GeneTree	ENSGT00390000004766.
HOGENOM	HOG000255147.
InParanoid	Q9W3R7.
KO	K08339.
OMA	HYPIGVL.
OrthoDB	EOG4NVX24.
PhylomeDB	Q9W3R7.
Gene expression databases
Bgee	Q9W3R7.
GermOnline	CG1643. Drosophila melanogaster.
Family and domain databases
InterPro	IPR007239. Atg5. [Graphical view]
PANTHER	PTHR13040. PTHR13040. 1 hit.
Pfam	PF04106. APG5. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	31666.
NextBio	774730.

Entry information

Entry name

ATG5_DROME

Accession

Primary (citable) accession number: Q9W3R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project