Unreviewed, UniProtKB/TrEMBL Q9W3I9 (Q9W3I9_DROME)

Names and origin

Protein names

Submitted name:
    TNF-receptor-associated factor 6 EMBL AAF46338.1
Submitted name:
    GH01161p EMBL AAK77233.1

Gene names

Name:	Traf6 FlyBase FBgn0026318
Synonyms:	Traf2 EMBL AAK77233.1 FlyBase FBgn0026318
ORF Names:	CG10961 FlyBase FBgn0026318, Dmel_CG10961 EMBL AAF46338.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Domain	Zinc-finger RuleBase RU000353V2
Ligand	Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Toll signaling pathway Traceable author statement. Source: FlyBase dorsal closure Traceable author statement. Source: FlyBase innate immune response Inferred from mutant phenotype. Source: FlyBase regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: FlyBase
Cellular component	intracellular Traceable author statement. Source: FlyBase
Molecular function	protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9W3I9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7D996A0B6600600D	FASTA	475	53,844
	10 20 30 40 50 60 MQRVQADQKP ARMHQHAHTH SHAHSLQHAE EKEHNSNEMT TNLSSTGRIA ASSSATPSAA 70 80 90 100 110 120 AGGGASGAPT PPKSLALNQN HHYAPGSDTS GEQEEELLDS RYECAICIDW LNEPVLTSCG 130 140 150 160 170 180 HRFCRSCLTA WMQKNNQCCP MDNKRLSAEH DIFPDNYTRR EIEQLKRDCP NSSLGCSVVA 190 200 210 220 230 240 SPIELHRHLP SCPYRRQQEP QEEKCPFAKI KCDFVGRPET NQLEEHLKAD MPHHMQLMLQ 250 260 270 280 290 300 AFQQTAIATW QPHKPSTSGA AVENGHGQQQ LPPPPQYANG VDEQIVQTMY QRIVVLEQRT 310 320 330 340 350 360 REQETRLENM QKQLRLARQQ APVDPRYSNG TIVWRIEQLG ALVARLRANA NNQVYSHECY 370 380 390 400 410 420 TSPHGYKFCA RLNIQPRKPH VLSLHVHLMQ SENDYHLDWP FKGRIKLCMV HPADATLSQH 430 440 450 460 470 DTIMTKPEIL AFHKPREAIS TRGFGFLEYA NISNIIQLGF CADDRLLIKI EINIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAK77233.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014298 Genomic DNA. Translation: AAF46338.1. AY047501 mRNA. Translation: AAK77233.1.
RefSeq	NP_511080.2.
UniGene	Dm.2940
3D structure databases
HSSP	HSSP built from PDB template 1LB4 based on UniProtKB Q9Y4K3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9W3I9. 18 interactions.
Proteomic databases
PRIDE	Q9W3I9.
Genome annotation databases
Ensembl	FBgn0026318. Drosophila melanogaster. [Contig view]
GeneID	31746.
KEGG	dme:Dmel_CG10961.
NMPDR	fig|7227.3.peg.16955.
Organism-specific databases
FlyBase	FBgn0026318. Traf6.
Phylogenomic databases
OMA	Q9W3I9. LMQSEND.
Gene expression databases
ArrayExpress	Q9W3I9.
Family and domain databases
InterPro	IPR002083. MATH. IPR013322. TRAF-type. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Gene3D	G3DSA:2.60.210.10. TRAF-type. 1 hit.
Pfam	PF00097. zf-C3HC4. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS50144. MATH. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	775130.

Entry information

Entry name

Q9W3I9_DROME

Accession

Primary (citable) accession number: Q9W3I9

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)