Reviewed,
UniProtKB/Swiss-Prot Q9W3C7 (PPT1_DROME)
Last modified
January 19, 2010.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Palmitoyl-protein thioesterase 1 Short name=PPT-1 EC=3.1.2.22 Alternative name(s): Palmitoyl-protein hydrolase 1 | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 314 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. Ref.1 Ref.5 |
| Catalytic activity | Palmitoyl-protein + H2O = palmitate + protein. |
| Subcellular location | Lysosome Probable. |
| Tissue specificity | Ubiquitously expressed. Ref.1 |
| Miscellaneous | Flies deficient in Ppt1 are viable and fertile, but accumulate abnormal autofluorescent storage material in the adult central nervous system and have a shorter life span. |
| Sequence similarities | Belongs to the palmitoyl-protein thioesterase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | determination of adult lifespan Ref.5 Inferred from mutant phenotype. Source: FlyBase protein depalmitoylation Ref.1 Ref.5Inferred from mutant phenotype. Source: FlyBase |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | palmitoyl-(protein) hydrolase activity Ref.1 Ref.5 Inferred from direct assay. Source: UniProtKB protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Potential | ||||||||
| Chain | 26 – 314 | 289 | Palmitoyl-protein thioesterase 1 | PRO_0000247505 | |||||||
Sites | |||||||||||
| Active site | 123 | 1 | Nucleophile By similarity | ||||||||
| Active site | 241 | 1 | By similarity | ||||||||
| Active site | 295 | 1 | By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 240 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 53 ↔ 54 | By similarity | |||||||||
| Disulfide bond | 104 ↔ 136 | By similarity | |||||||||
| Disulfide bond | 160 ↔ 168 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 85 | 1 | L → W in AAS93752. Ref.4 | ||||||||
| Sequence conflict | 133 | 1 | A → S in AAS93752. Ref.4 | ||||||||
| Sequence conflict | 176 | 1 | D → G in AAS93752. Ref.4 | ||||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF513720 mRNA. Translation: AAM49613.1. AE014298 Genomic DNA. Translation: AAF46403.2. AY118317 mRNA. Translation: AAM48346.1. Different initiation. BT012481 mRNA. Translation: AAS93752.1. |
| RefSeq | NP_727284.1. |
| UniGene | Dm.20735 |
3D structure databases | |
| SMR | Q9W3C7. Positions 38-311. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9W3C7. 1 interaction. |
| STRING | Q9W3C7. |
Genome annotation databases | |
| Ensembl | FBtr0071225; FBpp0071170; FBgn0030057; Drosophila melanogaster. [Genome view] |
| GeneID | 31805. |
| KEGG | dme:Dmel_CG12108. |
| NMPDR | fig|7227.3.peg.17035. |
Organism-specific databases | |
| CTD | 31805. |
| FlyBase | FBgn0030057. Ppt1. |
Phylogenomic databases | |
| eggNOG | inNOG04855. |
| InParanoid | Q9W3C7. |
| OMA | SSHICDL. |
| OrthoDB | EOG9T4D1W. |
| PhylomeDB | Q9W3C7. |
Enzyme and pathway databases | |
| BRENDA | 3.1.2.22. 48. |
Gene expression databases | |
| GermOnline | CG12108. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR002472. Palm_thioest. [Graphical view] |
| Pfam | PF02089. Palm_thioest. 1 hit. [Graphical view] |
| PRINTS | PR00414. PPTHIESTRASE. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 775404. |
Entry information
| Entry name | PPT1_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9W3C7 Secondary accession number(s): Q6NL60, Q8MT82 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


