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Protein

Frataxin homolog, mitochondrial

Gene

fh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+. May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.1 Publication

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: FlyBase
  • axonal transport of mitochondrion Source: FlyBase
  • cellular iron ion homeostasis Source: FlyBase
  • cellular response to oxidative stress Source: GO_Central
  • determination of adult lifespan Source: FlyBase
  • heme biosynthetic process Source: UniProtKB-KW
  • ion transport Source: UniProtKB-KW
  • iron incorporation into metallo-sulfur cluster Source: GO_Central
  • lipid catabolic process Source: FlyBase
  • mitochondrion organization Source: GO_Central
  • positive regulation of ecdysteroid biosynthetic process Source: FlyBase
  • positive regulation of heart contraction Source: FlyBase
  • pupariation Source: FlyBase
  • regulation of mitochondrial membrane potential Source: FlyBase
  • response to hydrogen peroxide Source: FlyBase
  • response to iron ion Source: FlyBase
  • response to oxidative stress Source: FlyBase

Keywordsi

Molecular functionOxidoreductase
Biological processHeme biosynthesis, Ion transport, Iron storage, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Frataxin homolog, mitochondrial (EC:1.16.3.1)
Short name:
Dfh
Gene namesi
Name:fh
ORF Names:CG8971
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030092. fh.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • axon cytoplasm Source: GOC
  • mitochondrion Source: FlyBase

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010133? – 190Frataxin homolog, mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PaxDbiQ9W385.
PRIDEiQ9W385.

Expressioni

Developmental stagei

Expressed throughout development, levels are high during embryogenesis but low in following stages.1 Publication

Gene expression databases

BgeeiFBgn0030092.
ExpressionAtlasiQ9W385. differential.
GenevisibleiQ9W385. DM.

Interactioni

Subunit structurei

Monomer (probable predominant form). Oligomer (By similarity).By similarity

Protein-protein interaction databases

BioGridi58300. 2 interactors.
IntActiQ9W385. 1 interactor.
STRINGi7227.FBpp0071283.

Structurei

3D structure databases

ProteinModelPortaliQ9W385.
SMRiQ9W385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the frataxin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3413. Eukaryota.
COG1965. LUCA.
InParanoidiQ9W385.
KOiK19054.
OMAiYKHSGQS.
OrthoDBiEOG091G0UR5.
PhylomeDBiQ9W385.

Family and domain databases

Gene3Di3.30.920.10. 1 hit.
InterProiView protein in InterPro
IPR017789. Frataxin.
IPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
PANTHERiPTHR16821. PTHR16821. 1 hit.
PfamiView protein in Pfam
PF01491. Frataxin_Cyay. 1 hit.
PRINTSiPR00904. FRATAXIN.
SMARTiView protein in SMART
SM01219. Frataxin_Cyay. 1 hit.
SUPFAMiSSF55387. SSF55387. 1 hit.
TIGRFAMsiTIGR03421. FeS_CyaY. 1 hit.
TIGR03422. mito_frataxin. 1 hit.
PROSITEiView protein in PROSITE
PS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAGRLMVRS IVGRACLATM GRWSKPQAHA SQVILPSTPA IAAVAIQCEE
60 70 80 90 100
FTANRRLFSS QIETESTLDG ATYERVCSDT LDALCDYFEE LTENASELQG
110 120 130 140 150
TDVAYSDGVL TVNLGGQHGT YVINRQTPNK QIWLSSPTSG PKRYDFVGTV
160 170 180 190
AAGRWIYKHS GQSLHELLQQ EIPGILKSQS VDFLRLPYCS
Length:190
Mass (Da):20,922
Last modified:May 1, 2000 - v1
Checksum:i8C48332C239F3036
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002208 mRNA. Translation: CAC20098.1.
AF208491 mRNA. Translation: AAG35732.1.
AF208492 Genomic DNA. Translation: AAG35733.1.
AE014298 Genomic DNA. Translation: AAF46449.1.
AY094649 mRNA. Translation: AAM11002.1.
RefSeqiNP_511094.1. NM_078539.3.
UniGeneiDm.2903.

Genome annotation databases

EnsemblMetazoaiFBtr0071348; FBpp0071283; FBgn0030092.
GeneIDi31845.
KEGGidme:Dmel_CG8971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002208 mRNA. Translation: CAC20098.1.
AF208491 mRNA. Translation: AAG35732.1.
AF208492 Genomic DNA. Translation: AAG35733.1.
AE014298 Genomic DNA. Translation: AAF46449.1.
AY094649 mRNA. Translation: AAM11002.1.
RefSeqiNP_511094.1. NM_078539.3.
UniGeneiDm.2903.

3D structure databases

ProteinModelPortaliQ9W385.
SMRiQ9W385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58300. 2 interactors.
IntActiQ9W385. 1 interactor.
STRINGi7227.FBpp0071283.

Proteomic databases

PaxDbiQ9W385.
PRIDEiQ9W385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071348; FBpp0071283; FBgn0030092.
GeneIDi31845.
KEGGidme:Dmel_CG8971.

Organism-specific databases

CTDi2271.
FlyBaseiFBgn0030092. fh.

Phylogenomic databases

eggNOGiKOG3413. Eukaryota.
COG1965. LUCA.
InParanoidiQ9W385.
KOiK19054.
OMAiYKHSGQS.
OrthoDBiEOG091G0UR5.
PhylomeDBiQ9W385.

Miscellaneous databases

GenomeRNAii31845.
PROiPR:Q9W385.

Gene expression databases

BgeeiFBgn0030092.
ExpressionAtlasiQ9W385. differential.
GenevisibleiQ9W385. DM.

Family and domain databases

Gene3Di3.30.920.10. 1 hit.
InterProiView protein in InterPro
IPR017789. Frataxin.
IPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
PANTHERiPTHR16821. PTHR16821. 1 hit.
PfamiView protein in Pfam
PF01491. Frataxin_Cyay. 1 hit.
PRINTSiPR00904. FRATAXIN.
SMARTiView protein in SMART
SM01219. Frataxin_Cyay. 1 hit.
SUPFAMiSSF55387. SSF55387. 1 hit.
TIGRFAMsiTIGR03421. FeS_CyaY. 1 hit.
TIGR03422. mito_frataxin. 1 hit.
PROSITEiView protein in PROSITE
PS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFRDA_DROME
AccessioniPrimary (citable) accession number: Q9W385
Secondary accession number(s): Q9GQQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 12, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.