Reviewed, UniProtKB/Swiss-Prot Q9W385 (FRDA_DROME)

Names and origin

Protein names

Recommended name:
    Frataxin homolog, mitochondrial
      Short name=Dfh

Gene names

Name:	fh
ORF Names:	CG8971

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably involved in iron homeostasis By similarity.
Subcellular location	Mitochondrion By similarity.
Developmental stage	Expressed throughout development, levels are high during embryogenesis but low in following stages. Ref.1
Sequence similarities	Belongs to the frataxin family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular iron ion homeostasis Inferred from electronic annotation. Source: InterPro response to hydrogen peroxide Inferred from mutant phenotype. Source: FlyBase
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion
	Chain	? – 190		Frataxin homolog, mitochondrial		PRO_0000010133

Sequences

	Sequence		Length	Mass (Da)
	Q9W385-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8C48332C239F3036	FASTA	190	20,922
	10 20 30 40 50 60 MFAGRLMVRS IVGRACLATM GRWSKPQAHA SQVILPSTPA IAAVAIQCEE FTANRRLFSS 70 80 90 100 110 120 QIETESTLDG ATYERVCSDT LDALCDYFEE LTENASELQG TDVAYSDGVL TVNLGGQHGT 130 140 150 160 170 180 YVINRQTPNK QIWLSSPTSG PKRYDFVGTV AAGRWIYKHS GQSLHELLQQ EIPGILKSQS 190 VDFLRLPYCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"dfh is a Drosophila homolog of the Friedreich's ataxia disease gene." Canizares-Sales J., Blanca-Postigo J.M., Navarro J.A., Monros E., Palau-Martinez F., Molto-Ruiz M.D. Gene 256:35-42(2000) [PubMed: 11054533] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ002208 mRNA. Translation: CAC20098.1. AF208491 mRNA. Translation: AAG35732.1. AF208492 Genomic DNA. Translation: AAG35733.1. AE014298 Genomic DNA. Translation: AAF46449.1. AY094649 mRNA. Translation: AAM11002.1.
RefSeq	NP_511094.1.
UniGene	Dm.2903
3D structure databases
HSSP	HSSP built from PDB template 1EKG based on UniProtKB Q16595.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9W385. 1 interaction.
Proteomic databases
PRIDE	Q9W385.
Genome annotation databases
Ensembl	FBgn0030092. Drosophila melanogaster. [Contig view]
GeneID	31845.
KEGG	dme:Dmel_CG8971.
NMPDR	fig|7227.3.peg.17097.
Organism-specific databases
FlyBase	FBgn0030092. fh.
Phylogenomic databases
HOGENOM	Q9W385.
OMA	Q9W385. ENASELQ.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-001174-MON.
Gene expression databases
ArrayExpress	Q9W385.
GermOnline	CG8971. Drosophila melanogaster.
Family and domain databases
InterPro	IPR017789. Frataxin. IPR002908. Frataxin-like. IPR001794. Frataxin_sub. [Graphical view]
Gene3D	G3DSA:3.30.920.10. Frataxin_like. 1 hit.
Pfam	PF01491. Frataxin_Cyay. 1 hit. [Graphical view]
PRINTS	PR00904. FRATAXIN.
ProDom	PD238818. Frataxin_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03421. FeS_CyaY. 1 hit. TIGR03422. mito_frataxin. 1 hit.
PROSITE	PS01344. FRATAXIN_1. 1 hit. PS50810. FRATAXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	775622.

Entry information

Entry name

FRDA_DROME

Accession

Primary (citable) accession number: Q9W385
Secondary accession number(s): Q9GQQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project