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Protein

Synembryn

Gene

ric8a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors. In addition to its GEF activity, it plays an essential role in cortical subcellular localization of heterotrimeric G proteins, suggesting it acts as a facilitator of G-alpha function through control of its membrane targeting and/or assembling of associated components rather than a GEF. Also required during gastrulation and sensory organ precursors (SOP) formation.3 Publications

GO - Molecular functioni

GO - Biological processi

  • asymmetric cell division Source: UniProtKB
  • establishment of mitotic spindle localization Source: UniProtKB
  • establishment or maintenance of cell polarity Source: UniProtKB
  • gastrulation involving germ band extension Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • neuroblast division Source: UniProtKB
  • protein localization Source: UniProtKB
  • protein stabilization Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Guanine-nucleotide releasing factor
Biological processGastrulation

Names & Taxonomyi

Protein namesi
Recommended name:
Synembryn
Alternative name(s):
Protein Ric-8
Gene namesi
Name:ric8a
Synonyms:l(1)G0397, Ric8
ORF Names:CG15797
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0028292 ric8a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002359051 – 573SynembrynAdd BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei477Phosphoserine1 Publication1
Modified residuei478Phosphoserine1 Publication1
Modified residuei480Phosphoserine1 Publication1
Modified residuei483Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9W358
PRIDEiQ9W358

PTM databases

iPTMnetiQ9W358

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiFBgn0028292
ExpressionAtlasiQ9W358 differential
GenevisibleiQ9W358 DM

Interactioni

Subunit structurei

Interacts with GDP-bound G(i)-alpha protein G-i-alpha-65A. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi583247 interactors.
IntActiQ9W358 4 interactors.
STRINGi7227.FBpp0071252

Structurei

3D structure databases

ProteinModelPortaliQ9W358
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the synembryn family.Curated

Phylogenomic databases

eggNOGiKOG4464 Eukaryota
ENOG410XSCJ LUCA
InParanoidiQ9W358
OMAiDSWNVHS
OrthoDBiEOG091G07N6
PhylomeDBiQ9W358

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR019318 Gua_nucleotide_exch_fac_Ric8
IPR008376 Synembryn
PANTHERiPTHR12425 PTHR12425, 1 hit
PfamiView protein in Pfam
PF10165 Ric8, 1 hit
PRINTSiPR01802 SYNEMBRYN
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q9W358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METEHLKRLE AKEADHIPAI LDEFNTKNAD LLVFDSFRTD NLWHELWLAI
60 70 80 90 100
FGILDDQRLS HLHTQCLNTV RILTRDEFSL QTNYIEQEVN TLLKLARIEA
110 120 130 140 150
GSLKLPATPD ELKQEEREEP QLEPSQAQSE VIAEALKCLC NLVYQSSDCR
160 170 180 190 200
RQCLRQHCLD AILKRVASSM RHPCALEYYD MKLLFLLTAL EPAARSRLQI
210 220 230 240 250
DLNGLTYMTK WLDDKLGEDS VGEEQLNIIC ELLKVMFNVT SAPDKSPNEY
260 270 280 290 300
EIQSLHLTGV LRELLLRFGD LATEKDRAVV THAINLLTNI SGSCLTELTL
310 320 330 340 350
RCSNAELESH KEREQDNEKE KDTEAGAGAK PRECCSQCFE KRNVRSLDVL
360 370 380 390 400
LRYLRQSLAQ QEAEASSHEL LSPVLTVLVK CARSDRVMRH YLRQEILPPL
410 420 430 440 450
RDVSQRPEVG QELRNHLCRF LTLPAMILRD LSAELLFVLC KENVGRMIKY
460 470 480 490 500
TGYGNAAGLF AKRGILDCRR VEGTDYSSDS EDSDTEEYKQ QQQGINPVLG
510 520 530 540 550
CVEPRSKSHL DDISEEQKEY EAMQLVNLIE QLRQGGIVKP AMIDKDGRPQ
560 570
PLEHILQLQE ELPQQQLDQK RKT
Length:573
Mass (Da):65,602
Last modified:June 1, 2003 - v2
Checksum:i1E9CF9EE90C957B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46477.2
BT004873 mRNA Translation: AAO45229.1
RefSeqiNP_001285048.1, NM_001298119.1
NP_572550.2, NM_132322.4
UniGeneiDm.6684

Genome annotation databases

EnsemblMetazoaiFBtr0071317; FBpp0071252; FBgn0028292
FBtr0346166; FBpp0311994; FBgn0028292
GeneIDi31874
KEGGidme:Dmel_CG15797
UCSCiCG15797-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiRIC8_DROME
AccessioniPrimary (citable) accession number: Q9W358
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome