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Protein

Phosphotransferase

Gene

Hex-A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processGlycolysisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFLY:FBGN0001186-MONOMER
ReactomeiR-DME-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-DME-6798695 Neutrophil degranulation
R-DME-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphotransferaseUniRule annotation (EC:2.7.1.-UniRule annotation)
Gene namesi
Name:Hex-AImported
Synonyms:DM1Imported, Dmel\CG3001Imported, HEXImported, HexImported, HEX-AImported, Hex-A:BImported, HexAImported, hexokinaseImported, HKImported, HK-AImported
ORF Names:CG3001Imported, Dmel_CG3001Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001186 Hex-A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9W330

Expressioni

Gene expression databases

BgeeiFBgn0001186
ExpressionAtlasiQ9W330 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ9W330, 3 interactors
STRINGi7227.FBpp0071296

Structurei

3D structure databases

SMRiQ9W330
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 290Hexokinase_1InterPro annotationAdd BLAST196
Domaini296 – 530Hexokinase_2InterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00390000017159
OrthoDBiEOG091G08MD

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9W330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRELNGAMK SVSINSAQLN GHNNGGGLDE TDRVGVAQGA ALSATEKITT
60 70 80 90 100
TTAAATKSAT ATTNATTATA TTTNLTTHSP QQIALLSAAE KSKMVHELCQ
110 120 130 140 150
QLLLTDEQVQ ELCYRILHEL RRGLAKDTHP KANVKCFVTY VQDLPNGNER
160 170 180 190 200
GKFLALDLGG TNFRVLLIHL QENNDFQMES RIYAIPQHIM IGSGTQLFDH
210 220 230 240 250
IAECLSNFMA EHNVYKERLP LGFTFSFPLR QLGLTKGLLE TWTKGFNCAG
260 270 280 290 300
VVNEDVVQLL KDAIARRGDV QIDVCAILND TTGTLMSCAW KNHNCKIGLI
310 320 330 340 350
VGTGANACYM ERVEEAELFA AEDPRKKHVL INTEWGAFGD NGALDFVRTE
360 370 380 390 400
FDRDIDVHSI NPGKQTFEKM ISGMYMGELV RLVLVKMTQA GILFNGQDSE
410 420 430 440 450
VLNTRGLFFT KYVSEIEADE PGNFTNCRLV LEELGLTNAT DGDCANVRYI
460 470 480 490 500
CECVSKRAAH LVSAGIATLI NKMDEPTVTV GVDGSVYRFH PKFHNLMVEK
510 520 530 540
ISQLIKPGIT FDLMLSEDGS GRGAALVAAV ACREDILNGK K
Length:541
Mass (Da):59,229
Last modified:May 1, 2000 - v1
Checksum:i1722B60A6BB8F360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46507.1
AY069391 mRNA Translation: AAL39536.1
RefSeqiNP_524848.1, NM_080109.4
UniGeneiDm.1467

Genome annotation databases

EnsemblMetazoaiFBtr0071361; FBpp0071296; FBgn0001186
GeneIDi45875
UCSCiCG3001-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9W330_DROME
AccessioniPrimary (citable) accession number: Q9W330
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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