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Protein

Phosphotransferase

Gene

Hex-A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular glucose homeostasis Source: GO_Central
  • flight Source: FlyBase
  • glycolytic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFLY:FBGN0001186-MONOMER.
ReactomeiR-DME-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-DME-6798695. Neutrophil degranulation.
R-DME-70153. Glucose transport.
R-DME-70171. Glycolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphotransferaseUniRule annotation (EC:2.7.1.-UniRule annotation)
Gene namesi
Name:Hex-AImported
ORF Names:CG3001Imported, Dmel_CG3001Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001186. Hex-A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0001186.

Interactioni

Protein-protein interaction databases

MINTiMINT-815887.
STRINGi7227.FBpp0071296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 290Hexokinase_1InterPro annotationAdd BLAST196
Domaini296 – 530Hexokinase_2InterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.
OMAiCYMERVE.
OrthoDBiEOG091G08MD.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRELNGAMK SVSINSAQLN GHNNGGGLDE TDRVGVAQGA ALSATEKITT
60 70 80 90 100
TTAAATKSAT ATTNATTATA TTTNLTTHSP QQIALLSAAE KSKMVHELCQ
110 120 130 140 150
QLLLTDEQVQ ELCYRILHEL RRGLAKDTHP KANVKCFVTY VQDLPNGNER
160 170 180 190 200
GKFLALDLGG TNFRVLLIHL QENNDFQMES RIYAIPQHIM IGSGTQLFDH
210 220 230 240 250
IAECLSNFMA EHNVYKERLP LGFTFSFPLR QLGLTKGLLE TWTKGFNCAG
260 270 280 290 300
VVNEDVVQLL KDAIARRGDV QIDVCAILND TTGTLMSCAW KNHNCKIGLI
310 320 330 340 350
VGTGANACYM ERVEEAELFA AEDPRKKHVL INTEWGAFGD NGALDFVRTE
360 370 380 390 400
FDRDIDVHSI NPGKQTFEKM ISGMYMGELV RLVLVKMTQA GILFNGQDSE
410 420 430 440 450
VLNTRGLFFT KYVSEIEADE PGNFTNCRLV LEELGLTNAT DGDCANVRYI
460 470 480 490 500
CECVSKRAAH LVSAGIATLI NKMDEPTVTV GVDGSVYRFH PKFHNLMVEK
510 520 530 540
ISQLIKPGIT FDLMLSEDGS GRGAALVAAV ACREDILNGK K
Length:541
Mass (Da):59,229
Last modified:May 1, 2000 - v1
Checksum:i1722B60A6BB8F360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46507.1.
AY069391 mRNA. Translation: AAL39536.1.
RefSeqiNP_524848.1. NM_080109.4.
UniGeneiDm.1467.

Genome annotation databases

EnsemblMetazoaiFBtr0071361; FBpp0071296; FBgn0001186.
GeneIDi45875.
UCSCiCG3001-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF46507.1.
AY069391 mRNA. Translation: AAL39536.1.
RefSeqiNP_524848.1. NM_080109.4.
UniGeneiDm.1467.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-815887.
STRINGi7227.FBpp0071296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071361; FBpp0071296; FBgn0001186.
GeneIDi45875.
UCSCiCG3001-RA. d. melanogaster.

Organism-specific databases

CTDi45875.
FlyBaseiFBgn0001186. Hex-A.

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.
OMAiCYMERVE.
OrthoDBiEOG091G08MD.

Enzyme and pathway databases

BioCyciFLY:FBGN0001186-MONOMER.
ReactomeiR-DME-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-DME-6798695. Neutrophil degranulation.
R-DME-70153. Glucose transport.
R-DME-70171. Glycolysis.

Miscellaneous databases

ChiTaRSiHex-A. fly.
GenomeRNAii45875.

Gene expression databases

BgeeiFBgn0001186.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9W330_DROME
AccessioniPrimary (citable) accession number: Q9W330
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.