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Q9W2M2

- TREA_DROME

UniProt

Q9W2M2 - TREA_DROME

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Protein
Trehalase
Gene
Treh, CG9364
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei193 – 1931Substrate By similarity
Binding sitei237 – 2371Substrate By similarity
Binding sitei341 – 3411Substrate; via carbonyl oxygen By similarity
Active sitei343 – 3431Proton donor/acceptor By similarity
Active sitei541 – 5411Proton donor/acceptor By similarity
Binding sitei556 – 5561Substrate By similarity

GO - Molecular functioni

  1. alpha,alpha-trehalase activity Source: FlyBase
  2. trehalase activity Source: FlyBase

GO - Biological processi

  1. trehalose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Gene namesi
Name:Treh
ORF Names:CG9364
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003748. Treh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 596573Trehalase
PRO_0000012058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi451 – 4511N-linked (GlcNAc...)1 Publication
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9W2M2.
PRIDEiQ9W2M2.

Expressioni

Gene expression databases

BgeeiQ9W2M2.

Interactioni

Protein-protein interaction databases

BioGridi69627. 26 interactions.
DIPiDIP-23202N.
IntActiQ9W2M2. 6 interactions.
MINTiMINT-994217.

Structurei

3D structure databases

ProteinModelPortaliQ9W2M2.
SMRiQ9W2M2. Positions 59-574.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 2012Substrate binding By similarity
Regioni246 – 2483Substrate binding By similarity
Regioni307 – 3093Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1626.
GeneTreeiENSGT00390000006949.
InParanoidiQ9W2M2.
KOiK01194.
OMAiQRSEAMY.
OrthoDBiEOG7P02H6.
PhylomeDBiQ9W2M2.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform C (identifier: Q9W2M2-1) [UniParc]FASTAAdd to Basket

Also known as: F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFKLPTISLL LVSWSCLVAL SQAKTYSLPD LTTDYNNAIP VDEEEAQDPF    50
ASCKIYCEGN LLHTIQTAVP KLFADSKTFV DMKLNNSPDK TLEDFNAMME 100
AKNQTPSSED LKQFVDKYFS APGTELEKWT PTDWKENPSF LDLISDPDLK 150
QWGVELNSIW KDLGRKMKDE VSKNPEYYSI IPVPNPVIVP GGRFIEFYYW 200
DSYWIIRGLL YSQMFDTARG MIENFFSIVN RFGFIPNGGR VYYHGRSQPP 250
LLTGMVKSYV DFTNDDKFAI DALDTLEHEF EFFVNNHNVT VKNHSLCVYR 300
DSSSGPRPES YREDVETGEE FPTDEAKELH YSELKAGAES GMDFSSRWFI 350
SPTGTNDGNR SALSTTSIVP VDLNAYLYWN AKLIAEFHSK AGNTKKVTEY 400
ETKAEKLLLG IQEVLWNEEA GVWLDYDMIN QKPRDYYTPT NLSPLWVKAF 450
NISESEKISA SVMAYIERNK LDSFPGGVPN TLSYTGEQWD APNVWAPMQY 500
ILVEGLNNLN TPEAKNMSLK WATRWVKTNF AAFSKDRHMY EKYNADEFGV 550
GGGGGEYEVQ TGFGWSNGVI IEWLSKHGRD ISIGSGCGCL AGEKRQ 596

Note: No experimental confirmation available.

Length:596
Mass (Da):67,689
Last modified:May 1, 2000 - v1
Checksum:i600D03B2087929EC
GO
Isoform A (identifier: Q9W2M2-2) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MFKLPTISLLLVSWSCLVALSQAKTYSLPDLTTDYNNAIPVDEEEAQDPFASC → MASPANPSSNHKMNGNG

Note: No experimental confirmation available.

Show »
Length:560
Mass (Da):63,552
Checksum:iAB9992F3BB522733
GO
Isoform B (identifier: Q9W2M2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.

Show »
Length:515
Mass (Da):58,722
Checksum:i1580AADE103A1E25
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8181Missing in isoform B.
VSP_021831Add
BLAST
Alternative sequencei1 – 5353MFKLP…PFASC → MASPANPSSNHKMNGNG in isoform A.
VSP_007735Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF46668.1.
AE013599 Genomic DNA. Translation: AAF46669.1.
AE013599 Genomic DNA. Translation: AAM68192.1.
AY051466 mRNA. Translation: AAK92890.1.
RefSeqiNP_001261115.1. NM_001274186.1. [Q9W2M2-2]
NP_524821.1. NM_080082.3. [Q9W2M2-2]
NP_726023.1. NM_166421.2. [Q9W2M2-2]
NP_726024.1. NM_166422.2. [Q9W2M2-2]
NP_726025.1. NM_166423.3. [Q9W2M2-1]
NP_726026.1. NM_166424.2. [Q9W2M2-1]
NP_726027.1. NM_166425.2. [Q9W2M2-3]
UniGeneiDm.6686.

Genome annotation databases

EnsemblMetazoaiFBtr0071539; FBpp0071468; FBgn0003748. [Q9W2M2-1]
FBtr0071540; FBpp0071469; FBgn0003748. [Q9W2M2-1]
GeneIDi45368.
KEGGidme:Dmel_CG9364.
UCSCiCG9364-RA. d. melanogaster. [Q9W2M2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF46668.1 .
AE013599 Genomic DNA. Translation: AAF46669.1 .
AE013599 Genomic DNA. Translation: AAM68192.1 .
AY051466 mRNA. Translation: AAK92890.1 .
RefSeqi NP_001261115.1. NM_001274186.1. [Q9W2M2-2 ]
NP_524821.1. NM_080082.3. [Q9W2M2-2 ]
NP_726023.1. NM_166421.2. [Q9W2M2-2 ]
NP_726024.1. NM_166422.2. [Q9W2M2-2 ]
NP_726025.1. NM_166423.3. [Q9W2M2-1 ]
NP_726026.1. NM_166424.2. [Q9W2M2-1 ]
NP_726027.1. NM_166425.2. [Q9W2M2-3 ]
UniGenei Dm.6686.

3D structure databases

ProteinModelPortali Q9W2M2.
SMRi Q9W2M2. Positions 59-574.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 69627. 26 interactions.
DIPi DIP-23202N.
IntActi Q9W2M2. 6 interactions.
MINTi MINT-994217.

Protein family/group databases

CAZyi GH37. Glycoside Hydrolase Family 37.

Proteomic databases

PaxDbi Q9W2M2.
PRIDEi Q9W2M2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071539 ; FBpp0071468 ; FBgn0003748 . [Q9W2M2-1 ]
FBtr0071540 ; FBpp0071469 ; FBgn0003748 . [Q9W2M2-1 ]
GeneIDi 45368.
KEGGi dme:Dmel_CG9364.
UCSCi CG9364-RA. d. melanogaster. [Q9W2M2-1 ]

Organism-specific databases

CTDi 11181.
FlyBasei FBgn0003748. Treh.

Phylogenomic databases

eggNOGi COG1626.
GeneTreei ENSGT00390000006949.
InParanoidi Q9W2M2.
KOi K01194.
OMAi QRSEAMY.
OrthoDBi EOG7P02H6.
PhylomeDBi Q9W2M2.

Miscellaneous databases

GenomeRNAii 45368.
NextBioi 838071.
PROi Q9W2M2.

Gene expression databases

Bgeei Q9W2M2.

Family and domain databases

InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
[Graphical view ]
PANTHERi PTHR23403. PTHR23403. 1 hit.
Pfami PF01204. Trehalase. 1 hit.
[Graphical view ]
PRINTSi PR00744. GLHYDRLASE37.
SUPFAMi SSF48208. SSF48208. 1 hit.
PROSITEi PS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Head.
  4. "Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster."
    Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L., Panin V.
    Glycobiology 17:1388-1403(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-451, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Oregon-R.
    Tissue: Head.

Entry informationi

Entry nameiTREA_DROME
AccessioniPrimary (citable) accession number: Q9W2M2
Secondary accession number(s): Q0E903
, Q0E904, Q7YWL2, Q961P0, Q9W2M1, Q9W2M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi