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Protein
Submitted name:

Protein tyrosine phosphatase ERK

Gene

PTP-ER

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: FlyBase

GO - Biological processi

  • inactivation of MAPK activity Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • negative regulation of ERK1 and ERK2 cascade Source: FlyBase
  • negative regulation of Ras protein signal transduction Source: FlyBase
  • protein dephosphorylation Source: FlyBase
  • R7 cell fate commitment Source: FlyBase
  • Ras protein signal transduction Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase ERKImported
Submitted name:
Protein tyrosine phosphatase-ERK/Enhancer of Ras1Imported (EC:3.1.3.48Imported)
Gene namesi
Name:PTP-ERImported
ORF Names:CG9856Imported, Dmel_CG9856Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0016641. PTP-ER.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-1717457.
STRINGi7227.FBpp0071603.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini915 – 1367453Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1240 – 1358119TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00780000121945.
KOiK01104.
OMAiLPNTIFE.
OrthoDBiEOG7M3HZQ.

Family and domain databases

Gene3Di3.90.190.10. 4 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 3 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 5 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W2F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLRNNNKE NAPIEYPYPQ TPRPTHAAPS DTTPLEAGED AESNKSTPYF
60 70 80 90 100
TPLEYLQTSF EFPSPTVEVG GGVPGFPEHE DQEEEVFTPR QFTITSPHPA
110 120 130 140 150
AHVHHPSSSQ SPTLGRKFKR LSQYDRRSCS PHINTSSGEE RVSGRGIDKE
160 170 180 190 200
NTMPKGGSVD QDLENSLYLS KSEHNSPTIL FKDESSTTPG LEASRLSYSP
210 220 230 240 250
KLLSSINNLN VSGSPLNIIN SAGYKNGNFF RFPEIDHVVQ DAPMDTVCLE
260 270 280 290 300
EATRRDRSPA LAEPPEQQQQ KSEGRKNRKN KNNLTIRITD VPIKNSSQPS
310 320 330 340 350
PLPKPKTPTI KSTKEKARSL DSAANESELS IVVHNITESH GSCDDMETGQ
360 370 380 390 400
SQPSTSVIHH HLHLQQPASA IHSTSLSRLD SHLSLANQRR TPRRKSPGIN
410 420 430 440 450
TTDWLMYHRK QNPYQVQPTH CSSTTQSSLD SDASLTPSLG DFELKSACSV
460 470 480 490 500
DGGSKFGIGA SLAPRSAHKH NQLLHSSSTN LKTLPECLTL VEFSSSGGGP
510 520 530 540 550
KESPFKQKSM DLPMPTLQAK TTVSTSSMNL LQRRGSNHSL TLNLHSSCGN
560 570 580 590 600
LMNSGLSHSN YSLGSILNSK SSCNLDAGTA SQIRADQLPQ SHLLGSSQGS
610 620 630 640 650
RQGLFRRRGS NHSITLKTGH TTTSCGDLNS MQQLQQQQAM LSAEKYNRLN
660 670 680 690 700
MRTNSTGSGS GSGSNVPTPK RGLLERRGSN QSLTLNMGSI LGGAAGTEIQ
710 720 730 740 750
MTDIVQPKVT VCSCAAANQA PHQRKFFSTE NLNSSKANSQ KFFGQVCFGS
760 770 780 790 800
ASDLQPNPQQ DSVREDQAIG ATCTCAGTVR NIMTRPLSPQ TTSEEFKIYL
810 820 830 840 850
ASIQMLQSAS NPLNQFDLIR LNYVFDHSYQ TNRNIIEQPP VLGSNARDVE
860 870 880 890 900
TPTDMVPPSS EDSELLASYQ TVVSRMAQPI PELKENEQKR IFRDLHKEFW
910 920 930 940 950
DLPLNHQEKP MVFGSQTKNR YKTILPNENS RVLLESESSE LTSLLGEIKR
960 970 980 990 1000
TSSVTASEDL PYINANYIKG PDYVSKCYVA TQGPLPNTIF EFWLMIYQNT
1010 1020 1030 1040 1050
QRYIRRCVDG GSSSSPHVDR EQILQQYFQK IVMLTNFTEA NRQKCAVYFP
1060 1070 1080 1090 1100
IELNEIFAVA AKCEVFQLSA AARDYFDRYL TPTFVPDTVV ASSDAIDYEI
1110 1120 1130 1140 1150
SGRHIGVESV KVTLEGDLLE ALPAQGSFFL IKNVGIVRRN GYSVRKLVLL
1160 1170 1180 1190 1200
YCIRVPQSAS YHLQKIYCYH YWYPDWPDHH SPRDINTLLD TCLHVLNLGK
1210 1220 1230 1240 1250
CESEFDIYDD TRSERNAHLA AQRLEIYQQD IFNAVQPLPV IHCSAGIGRT
1260 1270 1280 1290 1300
GCFTAILNAV RQLRQSLAYS LTGMLTKSLT SSSTEEYHNP TDSDSSFTCN
1310 1320 1330 1340 1350
TIRHISHILD HRDAEAVKTP PSFDRLPKMP DIFVDVLGIV CNLRLQRGGM
1360 1370
VQNSEQYELI HRAICLYLKR TLALRRF
Length:1,377
Mass (Da):152,975
Last modified:October 1, 2002 - v2
Checksum:i9BBDDE009FF95074
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146594 mRNA. Translation: AAD38688.1.
AE013599 Genomic DNA. Translation: AAF46739.2.
RefSeqiNP_726092.1. NM_166465.2.
UniGeneiDm.3114.

Genome annotation databases

EnsemblMetazoaiFBtr0071686; FBpp0071603; FBgn0016641.
GeneIDi37461.
KEGGidme:Dmel_CG9856.
UCSCiCG9856-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146594 mRNA. Translation: AAD38688.1.
AE013599 Genomic DNA. Translation: AAF46739.2.
RefSeqiNP_726092.1. NM_166465.2.
UniGeneiDm.3114.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1717457.
STRINGi7227.FBpp0071603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071686; FBpp0071603; FBgn0016641.
GeneIDi37461.
KEGGidme:Dmel_CG9856.
UCSCiCG9856-RA. d. melanogaster.

Organism-specific databases

CTDi37461.
FlyBaseiFBgn0016641. PTP-ER.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00780000121945.
KOiK01104.
OMAiLPNTIFE.
OrthoDBiEOG7M3HZQ.

Miscellaneous databases

ChiTaRSiPTP-ER. fly.
GenomeRNAii37461.

Family and domain databases

Gene3Di3.90.190.10. 4 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 3 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 5 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development."
    Karim F.D., Rubin G.M.
    Mol. Cell 3:741-750(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9W2F3_DROME
AccessioniPrimary (citable) accession number: Q9W2F3
Secondary accession number(s): Q9Y0X8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.