Reviewed, UniProtKB/Swiss-Prot Q9W2D9 (EIF3K_DROME)

Names and origin

Protein names

Recommended name:
    Eukaryotic translation initiation factor 3 subunit K
      Short name=eIF3k
Alternative name(s):
    eIF-3 p25

Gene names

ORF Names:

CG10306

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity.
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the eIF-3 subunit K family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of translational initiation Inferred from electronic annotation. Source: InterPro translational initiation Inferred from electronic annotation. Source: InterPro
Cellular component	eukaryotic translation initiation factor 3 complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct ribosome binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VTU4	1	EBI-137124,EBI-178321
rg	Q9W4E2-1	1	EBI-137124,EBI-201281

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Eukaryotic translation initiation factor 3 subunit K		PRO_0000123550

Sequences

	Sequence		Length	Mass (Da)
	Q9W2D9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8FDEB01630DBFF1E	FASTA	222	25,666
	10 20 30 40 50 60 MSHLVKMENG QSQTIQEMLG CIERYNPDHL KTLESYVQDQ AKNNTYDLEA NLAVLKLYQF 70 80 90 100 110 120 NPHMLNFDIT YTILLKSLTS LPHTDFVMAK CLLLPQQMKD ENVQTIIDLA DILERADFTL 130 140 150 160 170 180 FWQRAEVNRN MFRHITGFHD SIRKFVSHVV GTTFQTIRKD LLKELLGGIE DSTLESWIKR 190 200 210 220 NGWKNQGQGL VIVAMQDDKI KTKNITEKIE FDNVGALMAQ CL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF46753.1. AY061068 mRNA. Translation: AAL28616.1.
RefSeq	NP_611604.1.
UniGene	Dm.3730
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:17941N.
IntAct	Q9W2D9. 5 interactions.
Proteomic databases
PRIDE	Q9W2D9.
Genome annotation databases
Ensembl	FBgn0034654. Drosophila melanogaster. [Contig view]
GeneID	37475.
KEGG	dme:Dmel_CG10306.
NMPDR	fig|7227.3.peg.6707.
Organism-specific databases
FlyBase	FBgn0034654. CG10306.
Phylogenomic databases
HOGENOM	Q9W2D9.
OMA	Q9W2D9. FVANHEG.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-005874-MON.
Gene expression databases
GermOnline	CG10306. Drosophila melanogaster.
Family and domain databases
InterPro	IPR005062. SAC3/GANP/Nin1/mts3/eIF-3-p25. IPR009374. Transl_init_fac_sub12_euk. IPR016020. Transl_init_fac_sub12_N_euk. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.25.40.250. Transl_init_fac_sub12_N_euk. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHER	PTHR13022. EIF-3_p25. 1 hit.
Pfam	PF03399. SAC3_GANP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	803831.

Entry information

Entry name

EIF3K_DROME

Accession

Primary (citable) accession number: Q9W2D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project