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Q9W1K5 (SESN_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sestrin homolog
Gene names
Name:Sesn
ORF Names:CG11299
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the sestrin family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9W1K5-1)

Also known as: A; B; C;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9W1K5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     80-111: AAARHQCPYLVKRYEKEFINQGGDSAWLGGLD → SIFRLLFPTFISLPNWPKTIAIDWANEEHGLL
     112-497: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9W1K5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     433-437: LLVRP → VRNQL
     438-497: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Sestrin homolog
PRO_0000221186

Amino acid modifications

Modified residue1851Phosphoserine Ref.4
Modified residue1901Phosphoserine Ref.4

Natural variations

Alternative sequence80 – 11132AAARH…LGGLD → SIFRLLFPTFISLPNWPKTI AIDWANEEHGLL in isoform 2.
VSP_006065
Alternative sequence112 – 497386Missing in isoform 2.
VSP_006066
Alternative sequence433 – 4375LLVRP → VRNQL in isoform 3.
VSP_006067
Alternative sequence438 – 49760Missing in isoform 3.
VSP_006068

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) (B) (C) [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 39AC03B8F653CA30

FASTA49755,853
        10         20         30         40         50         60 
MYYAVDYYAD MGQISQDCFA ATQTGASDFD MDELDDLDQV TQVIGYHPQF HDHFLATQNF 

        70         80         90        100        110        120 
IMKGDGPLPN DYRYYLAIIA AARHQCPYLV KRYEKEFINQ GGDSAWLGGL DFIPAKLRAI 

       130        140        150        160        170        180 
YDINKILAHR PWLLRKEHIE RLTKGKNSWS LSEVVHAMVL LSHFHSLSSF VFSCGLTQKL 

       190        200        210        220        230        240 
DGLSSPKLKS PPAAVAALAP TILITPTSPT EPQKGKPVLA EISLNNANPD YDSQTAASSN 

       250        260        270        280        290        300 
GGAPPDSANA VADGPDATTL NGYLATAQQL PQQHGISVET LMERMKVLSQ KQDECSEAEL 

       310        320        330        340        350        360 
SSRFQKVEQQ TAELAAVTPE AAVGVPTNLS HYVDDANFIY QDFARRGTES INTFRIQDYS 

       370        380        390        400        410        420 
WEDHGYSLVD GLYNDVGIFL DAKFRAAYNL TYCTMGGIKN VDTSKFRRAI WNYIQCIYGI 

       430        440        450        460        470        480 
RHDDYDYGEV NQLLVRPLKM FIKTACCFPE RITTKDYDSV LVELQDSEKV HVNLMIMEAR 

       490 
NQAELLYALR EIMRYMT 

« Hide

Isoform 2 [UniParc].

Checksum: 4C254D2829C4F254
Show »

FASTA11112,822
Isoform 3 [UniParc].

Checksum: 3BDF1D7E5125004A
Show »

FASTA43748,759

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Berkeley.
Tissue: Embryo.
[4]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185 AND SER-190, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013599 Genomic DNA. Translation: AAF47053.2.
AE013599 Genomic DNA. Translation: ABV53897.1.
AE013599 Genomic DNA. Translation: ABV53898.1.
AY069626 mRNA. Translation: AAL39771.1.
RefSeqNP_001097437.1. NM_001103967.1.
NP_001097438.1. NM_001103968.1.
NP_611821.1. NM_137977.3.
UniGeneDm.2037.

3D structure databases

ProteinModelPortalQ9W1K5.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-19601N.
IntActQ9W1K5. 5 interactions.
MINTMINT-343891.

Proteomic databases

PaxDbQ9W1K5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0072087; FBpp0071996; FBgn0034897.
FBtr0113113; FBpp0112026; FBgn0034897.
FBtr0113114; FBpp0112027; FBgn0034897.
GeneID37755.
KEGGdme:Dmel_CG11299.
UCSCCG11299-RA. d. melanogaster.

Organism-specific databases

CTD37755.
FlyBaseFBgn0034897. Sesn.

Phylogenomic databases

eggNOGNOG312456.
GeneTreeENSGT00440000040103.
InParanoidQ9W1K5.
KOK10141.
OMAWIISSSS.
OrthoDBEOG4VQ84M.
PhylomeDBQ9W1K5.

Gene expression databases

BgeeQ9W1K5.
GermOnlineCG11299. Drosophila melanogaster.

Family and domain databases

InterProIPR006730. PA26.
[Graphical view]
PANTHERPTHR12474. PTHR12474. 1 hit.
PfamPF04636. PA26. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi37755.
NextBio805253.

Entry information

Entry nameSESN_DROME
AccessionPrimary (citable) accession number: Q9W1K5
Secondary accession number(s): A8DYN7, Q9I7V1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: April 3, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Recent format changes

Overview of recent format changes

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families