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Protein

Probable transaldolase

Gene

Taldo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable transaldolase (Taldo), Transaldolase (CG2827-RA)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-DME-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-DME-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transaldolase (EC:2.2.1.2)
Gene namesi
Name:TaldoImported
Synonyms:TalImported
ORF Names:CG2827Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0023477. Taldo.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735691 – 331Probable transaldolaseAdd BLAST331

Proteomic databases

PaxDbiQ9W1G0.
PRIDEiQ9W1G0.

Expressioni

Gene expression databases

BgeeiFBgn0023477.
ExpressionAtlasiQ9W1G0. differential.
GenevisibleiQ9W1G0. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi63394. 4 interactors.
IntActiQ9W1G0. 9 interactors.
STRINGi7227.FBpp0072050.

Structurei

3D structure databases

ProteinModelPortaliQ9W1G0.
SMRiQ9W1G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772. Eukaryota.
COG0176. LUCA.
GeneTreeiENSGT00390000017361.
InParanoidiQ9W1G0.
KOiK00616.
OMAiMAFDKLH.
OrthoDBiEOG091G0FTU.
PhylomeDBiQ9W1G0.

Family and domain databases

CDDicd00957. Transaldolase_TalAB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
PANTHERiPTHR10683. PTHR10683. 1 hit.
PTHR10683:SF22. PTHR10683:SF22. 1 hit.
PfamiView protein in Pfam
PF00923. TAL_FSA. 1 hit.
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiView protein in PROSITE
PS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9W1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSDRTLKKQ KMSVLQELKK ITTIVADTGD FEAINIYKPT DATTNPSLIL
60 70 80 90 100
SASSMERYQP LVQKAVEYAK GKKGSVSEQV AEAMDYLCVL FGTEILKVVP
110 120 130 140 150
GRVSTEIDAR LSFDTKKSVE KALKLIALYK SLGVDKERIL IKLASTWEGI
160 170 180 190 200
KAAEILENEH GVHCNLTLLF SFAQAVACAE AGVTLISPFV GRILDWYVAN
210 220 230 240 250
TDTKKFEALK DPGVISVTNI YNYYKKFGYK TLVMGASFRN VGEIKALAGC
260 270 280 290 300
DLLTISPALL KELENETESV VTYLSVSNAK LQDIEKITVD ESRFRWLLNE
310 320 330
DAMATDKLSE GIRKFAVDTV KLENLIKTYL K
Length:331
Mass (Da):36,734
Last modified:November 9, 2004 - v2
Checksum:i7EB1CDDFC4441C6A
GO

Sequence cautioni

The sequence AAM50780 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF47106.2.
AY118920 mRNA. Translation: AAM50780.1. Different initiation.
RefSeqiNP_523835.2. NM_079111.3.
UniGeneiDm.6550.

Genome annotation databases

EnsemblMetazoaiFBtr0072141; FBpp0072050; FBgn0023477.
GeneIDi37804.
KEGGidme:Dmel_CG2827.
UCSCiCG2827-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiTALDO_DROME
AccessioniPrimary (citable) accession number: Q9W1G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 9, 2004
Last modified: August 30, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families