Unreviewed, UniProtKB/TrEMBL Q9W1E5 (Q9W1E5_DROME)

Names and origin

Protein names

Submitted name:
    Morula EMBL AAF47123.1
Submitted name:
    Anaphase-promoting complex subunit 2 EMBL AAM97765.1
    LD21042p EMBL ABY21739.1

Gene names

Name:	mr EMBL AAF47123.1 FlyBase FBgn0002791
ORF Names:	CG3060 FlyBase FBgn0002791, Dmel_CG3060 EMBL AAF47123.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	802 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the cullin family. RuleBase RU003829V0

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	negative regulation of synaptic growth at neuromuscular junction Inferred from mutant phenotype. Source: FlyBase regulation of cell cycle Traceable author statement. Source: FlyBase regulation of synaptic transmission Inferred from mutant phenotype. Source: FlyBase ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	anaphase-promoting complex Traceable author statement. Source: FlyBase cullin-RING ubiquitin ligase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ubiquitin protein ligase binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9W1E5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: FE3AF41E30CCA078	FASTA	802	91,594
	10 20 30 40 50 60 MCDFDALWAD VLRIFPVLGG ANAVSNDPVE ENVFQNVRQH LMVLGSIDTF AAVVDLEIQS 70 80 90 100 110 120 TIRNVLVPKF WKHIHDGLVS SKLQGWINDQ ALAIEALPDK NGLFTQFIDA INELHDSFQS 130 140 150 160 170 180 LMQVKPRLIQ LVGAETKPTA KTVKLMQEEG IKNCLRDCLL AQLPPNFSVV VGAFYWVHFK 190 200 210 220 230 240 LFTKASNLAL TTVDSDVFDE LLCVGCNFEA EQCCCQRLTD MVNKTNMKLF EMNLIDRLTG 250 260 270 280 290 300 SALTALIKLK IKEHISDTCM GIFDRSHLKQ LETWLSDVIM SWLTNIFTEW KSKDSISDIE 310 320 330 340 350 360 VPESVKSFKV KLTYFMYETF AQSVIGQFFS IIIDYPDSIP AIDDLKICME KIDMRVYLTE 370 380 390 400 410 420 SLRNSLEARI LHPGVNTMDI LTGYVAAIKA IRHLDSTGVI LEMVTAPIKD YLRKRNDTVR 430 440 450 460 470 480 RVVTGLTEEG PTDLSEELAK GETIKECKDS GTDEFSNWEN WQPDPFGIDA SIMQYNSSRK 490 500 510 520 530 540 MRSADIISMV VDIYGSKELF MTEYRNLMAD RLLAQLDFNS EKEIRNLELL KIRFGESLLH 550 560 570 580 590 600 SCEVMLKDVT DSKRINAHIH SDGDRTENQL FDISSLIVSA QFWPSFNKES LQLPEEIENE 610 620 630 640 650 660 FKKYTKAYEA YKGNRTLNWR TVTGRVNIEI EIGDRTMEMV VSPILAVIIY HFQTKNEWTI 670 680 690 700 710 720 EDLSSITKVP ASALRRRLSF WQNHGLISET TPGIFTLLEK ESEKSQYEDM SLAEADEEDL 730 740 750 760 770 780 ESAMASASDQ REEELQVFWS YIVGMLTNLD SMPIDRIHQM LKLFASHSGG VEFTQDELKH 790 800 FLQRKVREHK LIFSGGVYQL AK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C., Celniker S. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL ABY21739.1.
[4]	"The anaphase promoting complex/cyclosome is required during development for modified cell cycles." Kashevsky H., Wallace J.A., Reed B.H., Lai C., Hayashi-Hagihara A., Orr-Weaver T.L. Proc. Natl. Acad. Sci. U.S.A. 99:11217-11222(2002) [PubMed: 12169670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF47123.1. AY129297 mRNA. Translation: AAM97765.1. BT031326 mRNA. Translation: ABY21739.1.
RefSeq	NP_611862.1.
UniGene	Dm.759
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9W1E5. 7 interactions.
Proteomic databases
PRIDE	Q9W1E5.
Genome annotation databases
Ensembl	FBgn0002791. Drosophila melanogaster. [Contig view]
GeneID	45906.
KEGG	dme:Dmel_CG3060.
NMPDR	fig|7227.3.peg.7204.
Organism-specific databases
FlyBase	FBgn0002791. mr.
Phylogenomic databases
HOGENOM	Q9W1E5.
OMA	Q9W1E5. RIHQMLK.
Gene expression databases
ArrayExpress	Q9W1E5.
Family and domain databases
InterPro	IPR014786. APC2. IPR016158. Cullin_homology. IPR001373. Cullin_N. [Graphical view]
Pfam	PF08672. APC2. 1 hit. PF00888. Cullin. 1 hit. [Graphical view]
SMART	SM00182. CULLIN. 1 hit. [Graphical view]
PROSITE	PS50069. CULLIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	838467.

Entry information

Entry name

Q9W1E5_DROME

Accession

Primary (citable) accession number: Q9W1E5

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)