Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Breast cancer type 2 susceptibility protein homolog

Gene

Brca2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA repair Source: FlyBase
  • DNA synthesis involved in double-strand break repair via homologous recombination Source: UniProtKB
  • double-strand break repair via homologous recombination Source: FlyBase
  • meiotic DNA repair synthesis involved in reciprocal meiotic recombination Source: UniProtKB
  • meiotic recombination checkpoint Source: UniProtKB
  • regulation of transcription, DNA-templated Source: GO_Central
  • response to camptothecin Source: FlyBase

Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer type 2 susceptibility protein homolog1 Publication
Short name:
dmbrca21 Publication
Gene namesi
Name:Brca2Imported
ORF Names:CG30169
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0050169 Brca2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Induced sensitivity to DNA damage induced by irradiation or treatment with hydroxyurea/ Repair by homologous recombination is dramatically decreased. Instead, large flanking deletions are formed, and repair by the non-conservative single-strand annealing pathway predominates.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003929161 – 971Breast cancer type 2 susceptibility protein homologAdd BLAST971

Proteomic databases

PaxDbiQ9W157
PRIDEiQ9W157

Expressioni

Gene expression databases

BgeeiFBgn0050169
GenevisibleiQ9W157 DM

Interactioni

Subunit structurei

Interacts with Rad9 (PubMed:18266476). Interacts with spn-A/Rad51 (PubMed:17822964). Interacts with cyclin CycG (PubMed:22976300).3 Publications

Protein-protein interaction databases

BioGridi63488, 24 interactors
IntActiQ9W157, 8 interactors
MINTiQ9W157
STRINGi7227.FBpp0072209

Structurei

3D structure databases

ProteinModelPortaliQ9W157
SMRiQ9W157
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati570 – 604BRCA2 1Sequence analysisAdd BLAST35
Repeati671 – 705BRCA2 2Sequence analysisAdd BLAST35
Repeati746 – 780BRCA2 3Sequence analysisAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J3H8 Eukaryota
ENOG410ZXUJ LUCA
InParanoidiQ9W157
OMAiQWPGMDV
OrthoDBiEOG091G01TF
PhylomeDBiQ9W157

Family and domain databases

InterProiView protein in InterPro
IPR015525 BRCA2
IPR002093 BRCA2_repeat
PANTHERiPTHR11289 PTHR11289, 2 hits
PROSITEiView protein in PROSITE
PS50138 BRCA2_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q9W157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNGASGSH PNRLSQGRGA HARERGATVS AAANRSNIID EMAKICEADR
60 70 80 90 100
QTFAIARRTR GHERLAVDNS DFVAVEDLIL SYAEPTPEDQ VEMIMSDFCS
110 120 130 140 150
SPTYAEDEDE PSHESEPWFR FRNKRIRTYS RKRDPKSHKA VQNEKRRGSS
160 170 180 190 200
GLSVQRDLNT SFTSMACDFD ASSQKIHEVL LNLSQYFSAT ATASGPTPVP
210 220 230 240 250
SQIDLPTEAR QDSGDECFNA ELENLRDDLL QSGFTFEASF YENEHEQEGP
260 270 280 290 300
GTMADTIYGD SMQSVPTTRL RLESGKRNVW SDADSTLKKA DVEIAENKKL
310 320 330 340 350
LMGQTQAKNV DIEENTNFIL EGIPLSEWLT PMELPEISKD VIKHIPDKKL
360 370 380 390 400
KLEPSSQKEQ KSSKDSNASK VRGASKQSCD INTKNEGTTI LDQPNAAEQE
410 420 430 440 450
NLLNDGELLE EFLFNDWQPM QCSNGPSTSK NAIQGPKENI NSINLDDKEQ
460 470 480 490 500
PEKQTPNKSQ TISSHQLNGI RKKSFKFIEV SEEMKIKGEE FVDKVVSGLY
510 520 530 540 550
HFSHKCNLRT EEYSDNHSQV MESTQCAEFK SAPSKPIEIL DGKETYNAIA
560 570 580 590 600
KVDVGEINGK FSPLNNDTIA EPEFCGFRTA SNKAIPISEK MKIKTAEFMA
610 620 630 640 650
EFQSKETIQQ NDYLVHQPND KPTSVGLDTA LKRSIESSEE MRSKASKLVV
660 670 680 690 700
VDTTMREPHQ PTLDPVCRDL NESQFFGFRT ASNKAIEITE AMEKRGAMFL
710 720 730 740 750
AQSKATDQLN GWQPSDFPDV LPTSPNNEIH SINVENNKAV NTKTVSETEF
760 770 780 790 800
FGFRTASNKG IVISENTKIK VAQFMSEFQA ADASTDSNQP TVISEESRNI
810 820 830 840 850
DAKFVDEAAA EDSANKPTFC NVQSLKNTSD IEHFKHDFFV EHSAKEEHPL
860 870 880 890 900
CSQPLVRTPR RSQEIHSSLS QLAGKSPLDQ ATKKSVIARR NLLSLKRKRK
910 920 930 940 950
IILSTETSTS CALPTMERFA PKPSSTSTPL ADRDLNRSKD CTKNRQDAED
960 970
MSPICMQPKK SRRLGLSRSR Y
Length:971
Mass (Da):108,649
Last modified:November 13, 2007 - v3
Checksum:i9232DE2A667672CE
GO

Sequence cautioni

The sequence AAM51132 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti502F → S in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti567D → E in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti621K → Y in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti650V → D in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti791T → I in AAM51132 (PubMed:12537569).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti242E → K in strain: Zimbabwe30. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF47220.3
BT023811 mRNA Translation: AAZ66318.1
EU541213 Genomic DNA Translation: ACB30270.1
EU541214 Genomic DNA Translation: ACB30271.1
AY119272 mRNA Translation: AAM51132.1 Different initiation.
RefSeqiNP_611925.2, NM_138081.4
UniGeneiDm.13825

Genome annotation databases

EnsemblMetazoaiFBtr0072302; FBpp0072209; FBgn0050169
GeneIDi37916
KEGGidme:Dmel_CG30169
UCSCiCG30169-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiBRCA2_DROME
AccessioniPrimary (citable) accession number: Q9W157
Secondary accession number(s): B2CPK7
, B2CPK8, Q494G5, Q8MRU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health