Unreviewed, UniProtKB/TrEMBL Q9W145 (Q9W145_DROME)

Names and origin

Protein names

Submitted name:
    Start1, isoform A EMBL AAF47232.2
Submitted name:
    Putative cholesterol transporter EMBL AAR19767.1

Gene names

Name:	Start1 EMBL AAF47232.2 FlyBase FBgn0035028
ORF Names:	CG3522 EMBL AAR19767.1 FlyBase FBgn0035028, Dmel_CG3522 EMBL AAF47232.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 START domain. Spearmint SPM002913

Ontologies

Gene Ontology (GO)
Biological process	steroid biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cholesterol binding Inferred from electronic annotation. Source: InterPro cholesterol transporter activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9W145-1 [UniParc]. Last modified July 5, 2004. Version 2. Checksum: F043047A5ADD6FF1	FASTA	583	65,823
	10 20 30 40 50 60 MSNMDPSDVR STAQLILANA RQGNSAYNMQ YDMSRAHSIN LITEDFLAGY MQDGRMSVVR 70 80 90 100 110 120 RFFCLFVTFD LVFVSLLWLI CIVINGDNIF TAFHKQIVEY TIYKSLFDVV AVAICRFLVL 130 140 150 160 170 180 IFFYAILYIN HWSIIALSTS GSCLFLISKV FVFDWLDSKQ QVFEVILIIT SFILAWGEAW 190 200 210 220 230 240 FLDCRVIPQE RHAQHYFRTM TSNDRTPMEQ PAILIEQERP PQSVTDFYSL MDTARHSDEE 250 260 270 280 290 300 DELDDEYTQM GLDCLRKAYE IIESSDWKVE KVNQKGDTIH STQRDKIGKI YKLTARIKYP 310 320 330 340 350 360 AKALMEDLFY RIEDCPKWNP ALLESKIVRK INSYTDITYQ VSVGGGGGMV KSRDFVNLRS 370 380 390 400 410 420 CRLFYNGQIC DDDETAQLSS DDGNSSLNRS CEGSVSTISD GDSNTPLLPS SVSSCKATFP 430 440 450 460 470 480 TSSKGAAMPF DTLGNSLGAK SLGPIVNFDE EPPPLDQDEF EDAKDKVDGE ANNMTKPNVP 490 500 510 520 530 540 SVGKTKDRVW VTSAVSVQYA AVPPSPKYTR GQNIVSGFAF REIVGKSDSC IVEWVLCLDL 550 560 570 580 KGYIPRYVLD AALTSSMTDY ISNLRKHVNE LRQKGRGRAP RTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis." Roth G.E., Gierl M.S., Vollborn L., Meise M., Lintermann R., Korge G. Proc. Natl. Acad. Sci. U.S.A. 101:1601-1606(2004) [PubMed: 14745013] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF47232.2. AY455866 mRNA. Translation: AAR19767.1.
RefSeq	NP_611936.2.
UniGene	Dm.11675
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9W145. 1 interaction.
Protein family/group databases
TCDB	9.B.64.1.2. putative cholesterol transporter (Start1) family.
Genome annotation databases
Ensembl	FBgn0035028. Drosophila melanogaster. [Contig view]
GeneID	37927.
KEGG	dme:Dmel_CG3522.
Organism-specific databases
FlyBase	FBgn0035028. Start1.
Phylogenomic databases
HOGENOM	Q9W145.
OMA	Q9W145. LAWGEAW.
Gene expression databases
ArrayExpress	Q9W145.
Family and domain databases
InterPro	IPR019498. Cholesterol-capturing_domain. IPR000799. StAR. IPR002913. START_lipid_bd. [Graphical view]
Pfam	PF10457. MENTAL. 1 hit. PF01852. START. 1 hit. [Graphical view]
PRINTS	PR00978. STARPROTEIN.
PROSITE	PS50848. START. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	806088.

Entry information

Entry name

Q9W145_DROME

Accession

Primary (citable) accession number: Q9W145

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)