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Q9W0Y6

- PAIN_DROME

UniProt

Q9W0Y6 - PAIN_DROME

Protein

Transient receptor potential cation channel protein painless

Gene

pain

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.1 Publication

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: FlyBase
    2. calcium channel activity Source: FlyBase
    3. ion channel activity Source: FlyBase

    GO - Biological processi

    1. behavioral response to pain Source: FlyBase
    2. calcium ion transmembrane transport Source: FlyBase
    3. calcium ion transport Source: FlyBase
    4. copulation Source: FlyBase
    5. detection of mechanical stimulus involved in sensory perception Source: FlyBase
    6. detection of mechanical stimulus involved in sensory perception of pain Source: UniProtKB
    7. detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
    8. detection of temperature stimulus involved in thermoception Source: FlyBase
    9. feeding behavior Source: FlyBase
    10. male courtship behavior Source: FlyBase
    11. mechanosensory behavior Source: FlyBase
    12. negative gravitaxis Source: FlyBase
    13. olfactory behavior Source: FlyBase
    14. regulation of female receptivity Source: FlyBase
    15. regulation of heart contraction Source: FlyBase
    16. response to heat Source: FlyBase
    17. response to mechanical stimulus Source: FlyBase
    18. sensory perception of pain Source: FlyBase

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Sensory transduction, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel protein painless
    Gene namesi
    Name:pain
    ORF Names:CG15860
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0060296. pain.

    Subcellular locationi

    GO - Cellular componenti

    1. calcium channel complex Source: FlyBase
    2. integral component of membrane Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 913913Transient receptor potential cation channel protein painlessPRO_0000215374Add
    BLAST

    Proteomic databases

    PaxDbiQ9W0Y6.
    PRIDEiQ9W0Y6.

    Expressioni

    Tissue specificityi

    Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors.1 Publication

    Developmental stagei

    Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons.

    Gene expression databases

    BgeeiQ9W0Y6.

    Interactioni

    Protein-protein interaction databases

    BioGridi63553. 1 interaction.
    MINTiMINT-894981.
    STRINGi7227.FBpp0072323.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9W0Y6.
    SMRiQ9W0Y6. Positions 115-204, 368-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 490490CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini512 – 52312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini545 – 55511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini577 – 58610ExtracellularSequence Analysis
    Topological domaini608 – 62821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini650 – 70859ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini730 – 913184CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei491 – 51121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei556 – 57621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei587 – 60721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei629 – 64921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei709 – 72921Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati154 – 18936ANK 1Add
    BLAST
    Repeati260 – 28930ANK 2Add
    BLAST
    Repeati368 – 39730ANK 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267148.
    GeneTreeiENSGT00740000115514.
    InParanoidiQ9W0Y6.
    OMAiNGAICRT.
    OrthoDBiEOG74N5G3.
    PhylomeDBiQ9W0Y6.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9W0Y6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFNNCGFID PQAQLAGALA KQDIRQFVAA LDSGALADLQ DDRHTSIYEK    50
    ALSTPGCRDF IEACIDHGSQ VNYINKKLDK AAISYAADSR DPGNLAALLK 100
    YRPGNKVQVD RKYGQLTPLN SLAKNLTDEN APDVYSCMQL LLDYGASPNI 150
    VDQGEFTPLH HVLRKSKVKA GKKELIQLFL DHPELDIDSY RNGEVRRLLQ 200
    AQFPELKLPE ERHTGPEIDI QTLQRTLRDG DETLFEQQFA EYLQNLKGGA 250
    DNQLNAHQEE YFGLLQESIK RGRQRAFDVI LSTGMDINSR PGRANEANLV 300
    ETAVIYGNWQ ALERLLKEPN LRLTPDSKLL NAVIGRLDEP PYDGSSHQRC 350
    FELLINSDRV DINEADSGRL VPLFFAVKYR NTSAMQKLLK NGAYIGSKSA 400
    FGTLPIKDMP PEVLEEHFDS CITTNGERPG DQNFEIIIDY KNLMRQERDS 450
    GLNQLQDEMA PIAFIAESKE MRHLLQHPLI SSFLFLKWHR LSVIFYLNFL 500
    IYSLFTASII TYTLLKFHES DQRALTAFFG LLSWLGISYL ILRECIQWIM 550
    SPVRYFWSIT NIMEVALITL SIFTCMESSF DKETQRVLAV FTILLVSMEF 600
    CLLVGSLPVL SISTHMLMLR EVSNSFLKSF TLYSIFVLTF SLCFYILFGK 650
    SVEEDQSKSA TPCPPLGKKE GKDEEQGFNT FTKPIEAVIK TIVMLTGEFD 700
    AGSIQFTSIY TYLIFLLFVI FMTIVLFNLL NGLAVSDTQV IKAQAELNGA 750
    ICRTNVLSRY EQVLTGHGRA GFLLGNHLFR SICQRLMNIY PNYLSLRQIS 800
    VLPNDGNKVL IPMSDPFEMR TLKKASFQQL PLSAAVPQKK LLDPPLRLLP 850
    CCCSLLTGKC SQMSGRVVKR ALEVIDQKNA AEQRRKQEQI NDSRLKLIEY 900
    KLEQLIQLVQ DRK 913
    Length:913
    Mass (Da):103,507
    Last modified:May 1, 2000 - v1
    Checksum:iD89CC6082E1A03C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY268106 mRNA. Translation: AAP03646.1.
    AE013599 Genomic DNA. Translation: AAF47293.1.
    BT011483 mRNA. Translation: AAR99141.1.
    RefSeqiNP_611979.1. NM_138135.2.
    UniGeneiDm.14984.

    Genome annotation databases

    EnsemblMetazoaiFBtr0072417; FBpp0072323; FBgn0060296.
    GeneIDi37985.
    KEGGidme:Dmel_CG15860.
    UCSCiCG15860-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY268106 mRNA. Translation: AAP03646.1 .
    AE013599 Genomic DNA. Translation: AAF47293.1 .
    BT011483 mRNA. Translation: AAR99141.1 .
    RefSeqi NP_611979.1. NM_138135.2.
    UniGenei Dm.14984.

    3D structure databases

    ProteinModelPortali Q9W0Y6.
    SMRi Q9W0Y6. Positions 115-204, 368-410.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 63553. 1 interaction.
    MINTi MINT-894981.
    STRINGi 7227.FBpp0072323.

    Proteomic databases

    PaxDbi Q9W0Y6.
    PRIDEi Q9W0Y6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0072417 ; FBpp0072323 ; FBgn0060296 .
    GeneIDi 37985.
    KEGGi dme:Dmel_CG15860.
    UCSCi CG15860-RA. d. melanogaster.

    Organism-specific databases

    CTDi 37985.
    FlyBasei FBgn0060296. pain.

    Phylogenomic databases

    eggNOGi NOG267148.
    GeneTreei ENSGT00740000115514.
    InParanoidi Q9W0Y6.
    OMAi NGAICRT.
    OrthoDBi EOG74N5G3.
    PhylomeDBi Q9W0Y6.

    Miscellaneous databases

    GenomeRNAii 37985.
    NextBioi 806382.

    Gene expression databases

    Bgeei Q9W0Y6.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "painless, a Drosophila gene essential for nociception."
      Tracey W.D. Jr., Wilson R.I., Laurent G., Benzer S.
      Cell 113:261-273(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiPAIN_DROME
    AccessioniPrimary (citable) accession number: Q9W0Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3