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Q9W0Y6

- PAIN_DROME

UniProt

Q9W0Y6 - PAIN_DROME

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Protein
Transient receptor potential cation channel protein painless
Gene
pain, CG15860
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.1 Publication

GO - Molecular functioni

  1. calcium activated cation channel activity Source: FlyBase
  2. calcium channel activity Source: FlyBase
  3. ion channel activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. behavioral response to pain Source: FlyBase
  2. calcium ion transmembrane transport Source: FlyBase
  3. calcium ion transport Source: FlyBase
  4. copulation Source: FlyBase
  5. detection of mechanical stimulus involved in sensory perception Source: FlyBase
  6. detection of mechanical stimulus involved in sensory perception of pain Source: UniProtKB
  7. detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
  8. detection of temperature stimulus involved in thermoception Source: FlyBase
  9. feeding behavior Source: FlyBase
  10. male courtship behavior Source: FlyBase
  11. mechanosensory behavior Source: FlyBase
  12. negative gravitaxis Source: FlyBase
  13. olfactory behavior Source: FlyBase
  14. regulation of female receptivity Source: FlyBase
  15. regulation of heart contraction Source: FlyBase
  16. response to heat Source: FlyBase
  17. response to mechanical stimulus Source: FlyBase
  18. sensory perception of pain Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel protein painless
Gene namesi
Name:pain
ORF Names:CG15860
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0060296. pain.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 490490Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei491 – 51121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini512 – 52312Extracellular Reviewed prediction
Add
BLAST
Transmembranei524 – 54421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini545 – 55511Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei556 – 57621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini577 – 58610Extracellular Reviewed prediction
Transmembranei587 – 60721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini608 – 62821Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei629 – 64921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini650 – 70859Extracellular Reviewed prediction
Add
BLAST
Transmembranei709 – 72921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini730 – 913184Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. calcium channel complex Source: FlyBase
  2. integral component of membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Transient receptor potential cation channel protein painless
PRO_0000215374Add
BLAST

Proteomic databases

PaxDbiQ9W0Y6.
PRIDEiQ9W0Y6.

Expressioni

Tissue specificityi

Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors.1 Publication

Developmental stagei

Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons.

Gene expression databases

BgeeiQ9W0Y6.

Interactioni

Protein-protein interaction databases

BioGridi63553. 1 interaction.
MINTiMINT-894981.
STRINGi7227.FBpp0072323.

Structurei

3D structure databases

ProteinModelPortaliQ9W0Y6.
SMRiQ9W0Y6. Positions 115-204, 368-410.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati154 – 18936ANK 1
Add
BLAST
Repeati260 – 28930ANK 2
Add
BLAST
Repeati368 – 39730ANK 3
Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267148.
GeneTreeiENSGT00740000115514.
InParanoidiQ9W0Y6.
OMAiNGAICRT.
OrthoDBiEOG74N5G3.
PhylomeDBiQ9W0Y6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W0Y6-1 [UniParc]FASTAAdd to Basket

« Hide

MDFNNCGFID PQAQLAGALA KQDIRQFVAA LDSGALADLQ DDRHTSIYEK    50
ALSTPGCRDF IEACIDHGSQ VNYINKKLDK AAISYAADSR DPGNLAALLK 100
YRPGNKVQVD RKYGQLTPLN SLAKNLTDEN APDVYSCMQL LLDYGASPNI 150
VDQGEFTPLH HVLRKSKVKA GKKELIQLFL DHPELDIDSY RNGEVRRLLQ 200
AQFPELKLPE ERHTGPEIDI QTLQRTLRDG DETLFEQQFA EYLQNLKGGA 250
DNQLNAHQEE YFGLLQESIK RGRQRAFDVI LSTGMDINSR PGRANEANLV 300
ETAVIYGNWQ ALERLLKEPN LRLTPDSKLL NAVIGRLDEP PYDGSSHQRC 350
FELLINSDRV DINEADSGRL VPLFFAVKYR NTSAMQKLLK NGAYIGSKSA 400
FGTLPIKDMP PEVLEEHFDS CITTNGERPG DQNFEIIIDY KNLMRQERDS 450
GLNQLQDEMA PIAFIAESKE MRHLLQHPLI SSFLFLKWHR LSVIFYLNFL 500
IYSLFTASII TYTLLKFHES DQRALTAFFG LLSWLGISYL ILRECIQWIM 550
SPVRYFWSIT NIMEVALITL SIFTCMESSF DKETQRVLAV FTILLVSMEF 600
CLLVGSLPVL SISTHMLMLR EVSNSFLKSF TLYSIFVLTF SLCFYILFGK 650
SVEEDQSKSA TPCPPLGKKE GKDEEQGFNT FTKPIEAVIK TIVMLTGEFD 700
AGSIQFTSIY TYLIFLLFVI FMTIVLFNLL NGLAVSDTQV IKAQAELNGA 750
ICRTNVLSRY EQVLTGHGRA GFLLGNHLFR SICQRLMNIY PNYLSLRQIS 800
VLPNDGNKVL IPMSDPFEMR TLKKASFQQL PLSAAVPQKK LLDPPLRLLP 850
CCCSLLTGKC SQMSGRVVKR ALEVIDQKNA AEQRRKQEQI NDSRLKLIEY 900
KLEQLIQLVQ DRK 913
Length:913
Mass (Da):103,507
Last modified:May 1, 2000 - v1
Checksum:iD89CC6082E1A03C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY268106 mRNA. Translation: AAP03646.1.
AE013599 Genomic DNA. Translation: AAF47293.1.
BT011483 mRNA. Translation: AAR99141.1.
RefSeqiNP_611979.1. NM_138135.2.
UniGeneiDm.14984.

Genome annotation databases

EnsemblMetazoaiFBtr0072417; FBpp0072323; FBgn0060296.
GeneIDi37985.
KEGGidme:Dmel_CG15860.
UCSCiCG15860-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY268106 mRNA. Translation: AAP03646.1 .
AE013599 Genomic DNA. Translation: AAF47293.1 .
BT011483 mRNA. Translation: AAR99141.1 .
RefSeqi NP_611979.1. NM_138135.2.
UniGenei Dm.14984.

3D structure databases

ProteinModelPortali Q9W0Y6.
SMRi Q9W0Y6. Positions 115-204, 368-410.
ModBasei Search...

Protein-protein interaction databases

BioGridi 63553. 1 interaction.
MINTi MINT-894981.
STRINGi 7227.FBpp0072323.

Proteomic databases

PaxDbi Q9W0Y6.
PRIDEi Q9W0Y6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0072417 ; FBpp0072323 ; FBgn0060296 .
GeneIDi 37985.
KEGGi dme:Dmel_CG15860.
UCSCi CG15860-RA. d. melanogaster.

Organism-specific databases

CTDi 37985.
FlyBasei FBgn0060296. pain.

Phylogenomic databases

eggNOGi NOG267148.
GeneTreei ENSGT00740000115514.
InParanoidi Q9W0Y6.
OMAi NGAICRT.
OrthoDBi EOG74N5G3.
PhylomeDBi Q9W0Y6.

Miscellaneous databases

GenomeRNAii 37985.
NextBioi 806382.

Gene expression databases

Bgeei Q9W0Y6.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "painless, a Drosophila gene essential for nociception."
    Tracey W.D. Jr., Wilson R.I., Laurent G., Benzer S.
    Cell 113:261-273(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiPAIN_DROME
AccessioniPrimary (citable) accession number: Q9W0Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi