Q9W0Y1 (TINA1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Troponin C-akin-1 protein
EC=2.3.2.-

Alternative name(s):
Putative gamma-glutamylcyclotransferase

Gene names

Name:	Tina-1
ORF Names:	CG2803

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative gamma-glutamylcyclotransferase By similarity.
Tissue specificity	In embryos, expression is seen in heart cells of the dorsal vessel and hindgut visceral mesoderm. Ref.5
Sequence similarities	Belongs to the gamma-glutamylcyclotransferase family.
Sequence caution	The sequence AAL25392.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	heart development Traceable author statement PubMed 12837580. Source: FlyBase
Molecular_function	structural constituent of muscle Non-traceable author statement PubMed 12837580. Source: FlyBase transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Troponin C-akin-1 protein		PRO_0000184784
Regions
	Region	17 – 20	4	Substrate binding By similarity
Sites
	Active site	92	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9W0Y1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8FCDE6E575950F5F	FASTA	167	19,056
	10 20 30 40 50 60 MGQAKKVSSA LSKLFVYGAL KYGQPSNSIL ASSGNGFAKF WCKATTTQKL PLVIATRYNI 70 80 90 100 110 120 PFLLNKPGVG YYVTGEIYEV DDRMLNSLDN LEDCEEIYTR EMHDMNIGVG EGTVPCWVYL 130 140 150 160 LQKYPENLLS LRYLSSYENS TTHPYIMRHR RTHKHPAQDD LTYEAQN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-167. Strain: Berkeley. Tissue: Head.
[5]	"The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel." Lovato T.L., Nguyen T.P., Molina M.R., Cripps R.M. Development 129:5019-5027(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAF47298.1. BT011448 mRNA. Translation: AAR99106.1. AY060353 mRNA. Translation: AAL25392.1. Different initiation.
RefSeq	NP_001033974.1. NM_001038885.1. NP_611983.2. NM_138139.3.
UniGene	Dm.4023.
3D structure databases
ProteinModelPortal	Q9W0Y1.
SMR	Q9W0Y1. Positions 11-143.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-23056N.
MINT	MINT-931464.
STRING	7227.FBpp0072317.
Proteomic databases
PaxDb	Q9W0Y1.
PRIDE	Q9W0Y1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0072411; FBpp0072317; FBgn0035083.
GeneID	37989.
KEGG	dme:Dmel_CG2803.
Organism-specific databases
CTD	37989.
FlyBase	FBgn0035083. Tina-1.
Phylogenomic databases
eggNOG	NOG242813.
GeneTree	ENSGT00390000010543.
HOGENOM	HOG000136024.
InParanoid	Q9W0Y1.
OMA	VIATRYN.
OrthoDB	EOG4CJT0B.
PhylomeDB	Q9W0Y1.
Gene expression databases
Bgee	Q9W0Y1.
GermOnline	CG2803. Drosophila melanogaster.
Family and domain databases
Gene3D	3.10.490.10. 1 hit.
InterPro	IPR009288. AIG2-like. IPR013024. Butirosin_synth_BtrG-like. [Graphical view]
Pfam	PF06094. AIG2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	37989.
NextBio	806410.

Entry information

Entry name

TINA1_DROME

Accession

Primary (citable) accession number: Q9W0Y1
Secondary accession number(s): Q95T30

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project