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Q9W0E8 (ZER1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein zer-1 homolog
Alternative name(s):
Zyg-11 homolog B-like protein
Gene names
ORF Names:CG12084
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC By similarity.

Sequence similarities

Belongs to the zyg-11 family.

Contains 3 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 793793Protein zer-1 homolog
PRO_0000305092

Regions

Repeat84 – 10825LRR 1
Repeat187 – 21024LRR 2
Repeat269 – 29426LRR 3

Sequences

Sequence LengthMass (Da)Tools
Q9W0E8 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 2F4F43B3475A56DE

FASTA79390,366
        10         20         30         40         50         60 
MSCKVRLMED GSLDEEPLTL KEIAYQKLCN NLDIISSHRP DGQRGLNPGI VLPNEICDGF 

        70         80         90        100        110        120 
LENYQRFNRP LDDSVIRLFE DTHRTSLKIV NLRNSTLSSI GLETLMRHKL FALSLWYCDM 

       130        140        150        160        170        180 
ISVGSHHLLA HYGDSLRSLE LGISSHLLQY AEPNEKEPVD FQLTCPHLRR LVLNGVVMHH 

       190        200        210        220        230        240 
RLQFAHLHDL GHLDLTSCVL ANFSLEALGS LPNLHTLILF NVWPIANQLH AICCLRRLCT 

       250        260        270        280        290        300 
LDISISSSGN GHGTYDLPDQ TLEMLMDNLR HLTHLDISGT NLAGNGVATK ESTTTSGMQQ 

       310        320        330        340        350        360 
SPKMEQHFAL TDIPGLASRT QRPLQFLGLY HTAHWACKRH DIPALEVAGD ANEQQILTAA 

       370        380        390        400        410        420 
RYYHDRPVLL TRVLNDLYHL FRFENCKDIH TALDVVLSAM DRHLKFKHMQ ISGSATLFYI 

       430        440        450        460        470        480 
VKGRDRSKFG ALLRNHIIRT LLNGMEMHIT DDTMLRNGYL TLTQFHMPVD VLFEYERLIK 

       490        500        510        520        530        540 
ILLHGVSKTE QEGFVQRIAI YLLNTLACQV DGRQKLFLGE LGVVSTMFTL IKDRLTRSVF 

       550        560        570        580        590        600 
DDVMEVAWST MWNVTDETAI NCKRFLDGRG MEYFLKCLHT FPDRDELLRN MMGLLGNVAE 

       610        620        630        640        650        660 
VKWLRPKLMT QEFIEVFARL LDSLSDGIEV GGASASVVAR VREREMASAN HAYLRFQVSY 

       670        680        690        700        710        720 
NAAGVLAHIA SDGADAWTIK TPSREHVLER MVAAIQRWNI KSERNINYRS FEPILSLVRC 

       730        740        750        760        770        780 
YETPQCQHWA VWALANLTQV YPEKYCKLVE QENGIQILNE LIEHESPYCE IKRIARLVIE 

       790 
QCDSGSERMV VDG

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]"The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components."
Vasudevan S., Starostina N.G., Kipreos E.T.
EMBO Rep. 8:279-286(2007) [PubMed: 17304241] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014296 Genomic DNA. Translation: AAF47500.2.
AY128434 mRNA. Translation: AAM75027.1.
RefSeqNP_612112.1. NM_138268.1.
UniGeneDm.7072.

3D structure databases

ProteinModelPortalQ9W0E8.
SMRQ9W0E8. Positions 71-283.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9W0E8. 1 interaction.
MINTMINT-900920.
STRINGQ9W0E8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0072711; FBpp0072595; FBgn0043458.
GeneID192509.
KEGGdme:Dmel_CG12084.
NMPDRfig|7227.3.peg.7556.
UCSCCG12084-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0043458. CG12084.

Phylogenomic databases

eggNOGinNOG08757.
GeneTreeEMGT00050000012953.
InParanoidQ9W0E8.
OMACQHWAVW.
OrthoDBEOG4HMGR7.
PhylomeDBQ9W0E8.

Gene expression databases

BgeeQ9W0E8.

Family and domain databases

InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
Gene3DG3DSA:1.25.10.10. ARM-like. 2 hits.
KOK10350.
SUPFAMSSF48371. ARM-type_fold. 1 hit.
ProtoNetSearch...

Other

NextBio842233.

Entry information

Entry nameZER1_DROME
AccessionPrimary (citable) accession number: Q9W0E8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents