Reviewed, UniProtKB/Swiss-Prot Q9W0E8 (ZER1_DROME)

Names and origin

Protein names

Recommended name:
    Protein zer-1 homolog
Alternative name(s):
    Zyg-11 homolog B-like protein

Gene names

ORF Names:

CG12084

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	793 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC By similarity.
Sequence similarities	Belongs to the zyg-11 family. Contains 3 LRR (leucine-rich) repeats.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of ubiquitin-protein ligase activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	Cul2-RING ubiquitin ligase complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	binding Inferred from electronic annotation. Source: InterPro ubiquitin-protein ligase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 793	793	Protein zer-1 homolog		PRO_0000305092
Regions
	Repeat	84 – 108	25	LRR 1
	Repeat	187 – 210	24	LRR 2
	Repeat	269 – 294	26	LRR 3

Sequences

	Sequence		Length	Mass (Da)
	Q9W0E8-1 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 2F4F43B3475A56DE	FASTA	793	90,366
	10 20 30 40 50 60 MSCKVRLMED GSLDEEPLTL KEIAYQKLCN NLDIISSHRP DGQRGLNPGI VLPNEICDGF 70 80 90 100 110 120 LENYQRFNRP LDDSVIRLFE DTHRTSLKIV NLRNSTLSSI GLETLMRHKL FALSLWYCDM 130 140 150 160 170 180 ISVGSHHLLA HYGDSLRSLE LGISSHLLQY AEPNEKEPVD FQLTCPHLRR LVLNGVVMHH 190 200 210 220 230 240 RLQFAHLHDL GHLDLTSCVL ANFSLEALGS LPNLHTLILF NVWPIANQLH AICCLRRLCT 250 260 270 280 290 300 LDISISSSGN GHGTYDLPDQ TLEMLMDNLR HLTHLDISGT NLAGNGVATK ESTTTSGMQQ 310 320 330 340 350 360 SPKMEQHFAL TDIPGLASRT QRPLQFLGLY HTAHWACKRH DIPALEVAGD ANEQQILTAA 370 380 390 400 410 420 RYYHDRPVLL TRVLNDLYHL FRFENCKDIH TALDVVLSAM DRHLKFKHMQ ISGSATLFYI 430 440 450 460 470 480 VKGRDRSKFG ALLRNHIIRT LLNGMEMHIT DDTMLRNGYL TLTQFHMPVD VLFEYERLIK 490 500 510 520 530 540 ILLHGVSKTE QEGFVQRIAI YLLNTLACQV DGRQKLFLGE LGVVSTMFTL IKDRLTRSVF 550 560 570 580 590 600 DDVMEVAWST MWNVTDETAI NCKRFLDGRG MEYFLKCLHT FPDRDELLRN MMGLLGNVAE 610 620 630 640 650 660 VKWLRPKLMT QEFIEVFARL LDSLSDGIEV GGASASVVAR VREREMASAN HAYLRFQVSY 670 680 690 700 710 720 NAAGVLAHIA SDGADAWTIK TPSREHVLER MVAAIQRWNI KSERNINYRS FEPILSLVRC 730 740 750 760 770 780 YETPQCQHWA VWALANLTQV YPEKYCKLVE QENGIQILNE LIEHESPYCE IKRIARLVIE 790 QCDSGSERMV VDG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	"The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components." Vasudevan S., Starostina N.G., Kipreos E.T. EMBO Rep. 8:279-286(2007) [PubMed: 17304241] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014296 Genomic DNA. Translation: AAF47500.2. AY128434 mRNA. Translation: AAM75027.1.
RefSeq	NP_612112.1.
UniGene	Dm.7072
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9W0E8. 1 interaction.
Genome annotation databases
Ensembl	FBgn0043458. Drosophila melanogaster. [Contig view]
GeneID	192509.
KEGG	dme:Dmel_CG12084.
NMPDR	fig|7227.3.peg.7556.
Organism-specific databases
FlyBase	FBgn0043458. CG12084.
Phylogenomic databases
HOGENOM	Q9W0E8.
OMA	Q9W0E8. TLILFNV.
Gene expression databases
ArrayExpress	Q9W0E8.
Family and domain databases
InterPro	IPR011989. ARM-like. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	842233.

Entry information

Entry name

ZER1_DROME

Accession

Primary (citable) accession number: Q9W0E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project