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Protein

Probable chitinase 2

Gene

Cht2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168Proton donorPROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

  • chitin-based cuticle development Source: FlyBase
  • chitin-based embryonic cuticle biosynthetic process Source: FlyBase
  • chitin catabolic process Source: GO_Central
  • ecdysis, chitin-based cuticle Source: FlyBase
  • larval chitin-based cuticle development Source: FlyBase
  • polysaccharide catabolic process Source: UniProtKB-KW
  • wound healing Source: FlyBase

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chitinase 2 (EC:3.2.1.14)
Gene namesi
Name:Cht2Imported
ORF Names:CG2054
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0022702 Cht2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001194834 – 484Probable chitinase 2Sequence analysisAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei467Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9W092
PRIDEiQ9W092

PTM databases

iPTMnetiQ9W092

Expressioni

Gene expression databases

BgeeiFBgn0022702
ExpressionAtlasiQ9W092 differential
GenevisibleiQ9W092 DM

Interactioni

Protein-protein interaction databases

BioGridi63756, 1 interactor
IntActiQ9W092, 1 interactor
STRINGi7227.FBpp0297108

Structurei

3D structure databases

ProteinModelPortaliQ9W092
SMRiQ9W092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
HOGENOMiHOG000148795
InParanoidiQ9W092
KOiK01183
OMAiAYDVRQI
OrthoDBiEOG091G014W
PhylomeDBiQ9W092

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
SSF54556 SSF54556, 1 hit
PROSITEiView protein in PROSITE
PS01095 CHITINASE_18, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRSRLSGE APQLWLLLLL ASTASSLWAS VAARTGPLHD KVVVCYVSTW
60 70 80 90 100
AVYRPEQGAY AIENFDPNLC THVVYAFAGL DITQAAIKSL DPWQDLKEEY
110 120 130 140 150
GKGGYEKMTG LKRSHPHLKV SLAIGGWNEG SANYSTLVAN NLLRGRFVKQ
160 170 180 190 200
VSSFIRKYNF DGLDLDWEYP TQRKGKPADR ENFVLLTKEL REEFDEHGLL
210 220 230 240 250
LTSAIGASKK VIDEAYDVRQ ISRYLDYLHI MCYDYHGSWD RRVGYNAPLT
260 270 280 290 300
APADDPLSVK FSIDYLLKLG APPEKLVMGL PFYGRTFKTL ASGFLNDVSE
310 320 330 340 350
GVGFKGPYTR EDGFLGYNEI CQTLSNQTSG WTREWDPQTS QVLAKSERNV
360 370 380 390 400
FTQEINVVTY DSSRSIANKV LFAMSKRLAG VMVWSVDTDD FLGNCKLDED
410 420 430 440 450
TYEDFQKVTA APKRSSQNYP LLRTINEATM LAVDELAVPE PQPDDSENEI
460 470 480
PHGSIADRKN AGASMVSLGL GVTAVFMLLH RLAQ
Length:484
Mass (Da):54,122
Last modified:May 1, 2000 - v1
Checksum:iA2B77899332452D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47562.1
AY058589 mRNA Translation: AAL13818.1
AF026501 Genomic DNA Translation: AAB81859.1
RefSeqiNP_001246550.1, NM_001259621.2
NP_001261282.1, NM_001274353.1
NP_477298.2, NM_057950.4
UniGeneiDm.4242

Genome annotation databases

EnsemblMetazoaiFBtr0072795; FBpp0072677; FBgn0022702
FBtr0305966; FBpp0297108; FBgn0022702
FBtr0334075; FBpp0306200; FBgn0022702
GeneIDi38223
KEGGidme:Dmel_CG2054

Similar proteinsi

Entry informationi

Entry nameiCHIT2_DROME
AccessioniPrimary (citable) accession number: Q9W092
Secondary accession number(s): O17421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health