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Protein

Probable chitinase 2

Gene

Cht2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168Proton donorPROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

  • chitin-based cuticle development Source: FlyBase
  • chitin-based embryonic cuticle biosynthetic process Source: FlyBase
  • chitin catabolic process Source: GO_Central
  • ecdysis, chitin-based cuticle Source: FlyBase
  • larval chitin-based cuticle development Source: FlyBase
  • polysaccharide catabolic process Source: UniProtKB-KW
  • wound healing Source: FlyBase

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chitinase 2 (EC:3.2.1.14)
Gene namesi
Name:Cht2Imported
ORF Names:CG2054
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0022702. Cht2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular region Source: GO_Central
  • extracellular space Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001194834 – 484Probable chitinase 2Sequence analysisAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei467Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9W092.
PRIDEiQ9W092.

PTM databases

iPTMnetiQ9W092.

Expressioni

Gene expression databases

BgeeiFBgn0022702.
ExpressionAtlasiQ9W092. differential.
GenevisibleiQ9W092. DM.

Interactioni

Protein-protein interaction databases

BioGridi63756. 1 interactor.
IntActiQ9W092. 1 interactor.
MINTiMINT-801125.
STRINGi7227.FBpp0297108.

Structurei

3D structure databases

ProteinModelPortaliQ9W092.
SMRiQ9W092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806. Eukaryota.
COG3325. LUCA.
GeneTreeiENSGT00550000074323.
HOGENOMiHOG000148795.
InParanoidiQ9W092.
KOiK01183.
OMAiAYDVRQI.
OrthoDBiEOG091G014W.
PhylomeDBiQ9W092.

Family and domain databases

InterProiView protein in InterPro
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SMARTiView protein in SMART
SM00636. Glyco_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRSRLSGE APQLWLLLLL ASTASSLWAS VAARTGPLHD KVVVCYVSTW
60 70 80 90 100
AVYRPEQGAY AIENFDPNLC THVVYAFAGL DITQAAIKSL DPWQDLKEEY
110 120 130 140 150
GKGGYEKMTG LKRSHPHLKV SLAIGGWNEG SANYSTLVAN NLLRGRFVKQ
160 170 180 190 200
VSSFIRKYNF DGLDLDWEYP TQRKGKPADR ENFVLLTKEL REEFDEHGLL
210 220 230 240 250
LTSAIGASKK VIDEAYDVRQ ISRYLDYLHI MCYDYHGSWD RRVGYNAPLT
260 270 280 290 300
APADDPLSVK FSIDYLLKLG APPEKLVMGL PFYGRTFKTL ASGFLNDVSE
310 320 330 340 350
GVGFKGPYTR EDGFLGYNEI CQTLSNQTSG WTREWDPQTS QVLAKSERNV
360 370 380 390 400
FTQEINVVTY DSSRSIANKV LFAMSKRLAG VMVWSVDTDD FLGNCKLDED
410 420 430 440 450
TYEDFQKVTA APKRSSQNYP LLRTINEATM LAVDELAVPE PQPDDSENEI
460 470 480
PHGSIADRKN AGASMVSLGL GVTAVFMLLH RLAQ
Length:484
Mass (Da):54,122
Last modified:May 1, 2000 - v1
Checksum:iA2B77899332452D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47562.1.
AY058589 mRNA. Translation: AAL13818.1.
AF026501 Genomic DNA. Translation: AAB81859.1.
RefSeqiNP_001246550.1. NM_001259621.2.
NP_001261282.1. NM_001274353.1.
NP_477298.2. NM_057950.4.
UniGeneiDm.4242.

Genome annotation databases

EnsemblMetazoaiFBtr0072795; FBpp0072677; FBgn0022702.
FBtr0305966; FBpp0297108; FBgn0022702.
FBtr0334075; FBpp0306200; FBgn0022702.
GeneIDi38223.
KEGGidme:Dmel_CG2054.

Similar proteinsi

Entry informationi

Entry nameiCHIT2_DROME
AccessioniPrimary (citable) accession number: Q9W092
Secondary accession number(s): O17421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families