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Protein

DNA polymerase delta small subunit

Gene

CG12018

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The function of the small subunit is not yet clear.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: FlyBase
  • DNA replication Source: FlyBase
  • mitotic spindle organization Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiR-DME-69166. Removal of the Flap Intermediate.
R-DME-69183. Processive synthesis on the lagging strand.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta small subunit (EC:2.7.7.7)
Gene namesi
ORF Names:CG12018
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0027903. CG12018.

Subcellular locationi

GO - Cellular componenti

  • delta DNA polymerase complex Source: FlyBase
  • microtubule associated complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431DNA polymerase delta small subunitPRO_0000096170Add
BLAST

Proteomic databases

PaxDbiQ9W088.
PRIDEiQ9W088.

Expressioni

Gene expression databases

BgeeiFBgn0027903.
ExpressionAtlasiQ9W088. differential.
GenevisibleiQ9W088. DM.

Interactioni

Subunit structurei

Heterodimer with subunits of 125 kDa and 50 kDa.By similarity

Protein-protein interaction databases

BioGridi63760. 3 interactions.
DIPiDIP-20333N.
MINTiMINT-1686297.
STRINGi7227.FBpp0072658.

Structurei

3D structure databases

ProteinModelPortaliQ9W088.
SMRiQ9W088. Positions 26-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2732. Eukaryota.
COG1311. LUCA.
InParanoidiQ9W088.
KOiK02328.
OMAiDPANFML.
OrthoDBiEOG091G094I.
PhylomeDBiQ9W088.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
[Graphical view]
PANTHERiPTHR10416. PTHR10416. 1 hit.
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9W088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRLETKYE NLSSIFRLKG HDYQKQFFHL YAHRLAEMTR LLTPLAQKKW
60 70 80 90 100
GNKEPIKKLC ELRGEQDVHC ILIGTIFKHQ AHKPSILRDI SEENQLAPQP
110 120 130 140 150
PRQNYSDPED KIVLEDELQR VRLQGKLNGQ LLATGVVCAA LGGTDSDGFF
160 170 180 190 200
NVEDILFYES GPQKPLAPIK RSRLLVLASG LDQLQAHKFV EALNLFQYWL
210 220 230 240 250
AGSLGNNKEA GSMVRLIVAG NSVRASAMAH VPTLQVARTQ ANANDTVQAV
260 270 280 290 300
SQLDQWFASW ARSLPVDIMP GPYDPANFML PQQPFHKCMF PQAAQLATFQ
310 320 330 340 350
AVTNPYSCRL DEALVVGTSG QNVSDLLRST SLDSALEALR CTLTWGHVAP
360 370 380 390 400
TAPDTLACYP YIESDPFILR ECPHVYYAGN CESFATELHE GSEGKRTRLV
410 420 430
CVPSFSKTQS VAVVDLDTLD CRMVNFSVDA E
Length:431
Mass (Da):48,009
Last modified:May 1, 2000 - v1
Checksum:iD0A6EC18EF1EFAFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti363 – 3631E → D in AAM29316 (PubMed:12537569).Curated
Sequence conflicti393 – 3931E → D in AAM29316 (PubMed:12537569).Curated
Sequence conflicti423 – 4231M → I in AAM29316 (PubMed:12537569).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47566.1.
AF160903 mRNA. Translation: AAD46843.2.
AY113311 mRNA. Translation: AAM29316.1.
RefSeqiNP_647659.1. NM_139402.3.
UniGeneiDm.819.

Genome annotation databases

EnsemblMetazoaiFBtr0072775; FBpp0072658; FBgn0027903.
GeneIDi38228.
KEGGidme:Dmel_CG12018.
UCSCiCG12018-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47566.1.
AF160903 mRNA. Translation: AAD46843.2.
AY113311 mRNA. Translation: AAM29316.1.
RefSeqiNP_647659.1. NM_139402.3.
UniGeneiDm.819.

3D structure databases

ProteinModelPortaliQ9W088.
SMRiQ9W088. Positions 26-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63760. 3 interactions.
DIPiDIP-20333N.
MINTiMINT-1686297.
STRINGi7227.FBpp0072658.

Proteomic databases

PaxDbiQ9W088.
PRIDEiQ9W088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072775; FBpp0072658; FBgn0027903.
GeneIDi38228.
KEGGidme:Dmel_CG12018.
UCSCiCG12018-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0027903. CG12018.

Phylogenomic databases

eggNOGiKOG2732. Eukaryota.
COG1311. LUCA.
InParanoidiQ9W088.
KOiK02328.
OMAiDPANFML.
OrthoDBiEOG091G094I.
PhylomeDBiQ9W088.

Enzyme and pathway databases

ReactomeiR-DME-69166. Removal of the Flap Intermediate.
R-DME-69183. Processive synthesis on the lagging strand.

Miscellaneous databases

ChiTaRSiCG12018. fly.
GenomeRNAii38228.
PROiQ9W088.

Gene expression databases

BgeeiFBgn0027903.
ExpressionAtlasiQ9W088. differential.
GenevisibleiQ9W088. DM.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
[Graphical view]
PANTHERiPTHR10416. PTHR10416. 1 hit.
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPOD2_DROME
AccessioniPrimary (citable) accession number: Q9W088
Secondary accession number(s): Q8MZ80, Q9U9Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.