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Protein

DNA polymerase delta small subunit

Gene

CG12018

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The function of the small subunit is not yet clear.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-DME-69166 Removal of the Flap Intermediate
R-DME-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta small subunit (EC:2.7.7.7)
Gene namesi
ORF Names:CG12018
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0027903 CG12018

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000961701 – 431DNA polymerase delta small subunitAdd BLAST431

Proteomic databases

PaxDbiQ9W088
PRIDEiQ9W088

Expressioni

Gene expression databases

BgeeiFBgn0027903
ExpressionAtlasiQ9W088 baseline and differential
GenevisibleiQ9W088 DM

Interactioni

Subunit structurei

Heterodimer with subunits of 125 kDa and 50 kDa.By similarity

Protein-protein interaction databases

BioGridi63760, 3 interactors
DIPiDIP-20333N
STRINGi7227.FBpp0072658

Structurei

3D structure databases

ProteinModelPortaliQ9W088
SMRiQ9W088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2732 Eukaryota
COG1311 LUCA
InParanoidiQ9W088
KOiK02328
OMAiTRLIQMR
OrthoDBiEOG091G094I
PhylomeDBiQ9W088

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR024826 DNA_pol_delta/II_ssu
PANTHERiPTHR10416 PTHR10416, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit

Sequencei

Sequence statusi: Complete.

Q9W088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRLETKYE NLSSIFRLKG HDYQKQFFHL YAHRLAEMTR LLTPLAQKKW
60 70 80 90 100
GNKEPIKKLC ELRGEQDVHC ILIGTIFKHQ AHKPSILRDI SEENQLAPQP
110 120 130 140 150
PRQNYSDPED KIVLEDELQR VRLQGKLNGQ LLATGVVCAA LGGTDSDGFF
160 170 180 190 200
NVEDILFYES GPQKPLAPIK RSRLLVLASG LDQLQAHKFV EALNLFQYWL
210 220 230 240 250
AGSLGNNKEA GSMVRLIVAG NSVRASAMAH VPTLQVARTQ ANANDTVQAV
260 270 280 290 300
SQLDQWFASW ARSLPVDIMP GPYDPANFML PQQPFHKCMF PQAAQLATFQ
310 320 330 340 350
AVTNPYSCRL DEALVVGTSG QNVSDLLRST SLDSALEALR CTLTWGHVAP
360 370 380 390 400
TAPDTLACYP YIESDPFILR ECPHVYYAGN CESFATELHE GSEGKRTRLV
410 420 430
CVPSFSKTQS VAVVDLDTLD CRMVNFSVDA E
Length:431
Mass (Da):48,009
Last modified:May 1, 2000 - v1
Checksum:iD0A6EC18EF1EFAFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363E → D in AAM29316 (PubMed:12537569).Curated1
Sequence conflicti393E → D in AAM29316 (PubMed:12537569).Curated1
Sequence conflicti423M → I in AAM29316 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47566.1
AF160903 mRNA Translation: AAD46843.2
AY113311 mRNA Translation: AAM29316.1
RefSeqiNP_647659.1, NM_139402.3
UniGeneiDm.819

Genome annotation databases

EnsemblMetazoaiFBtr0072775; FBpp0072658; FBgn0027903
GeneIDi38228
KEGGidme:Dmel_CG12018
UCSCiCG12018-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiDPOD2_DROME
AccessioniPrimary (citable) accession number: Q9W088
Secondary accession number(s): Q8MZ80, Q9U9Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health