Reviewed, UniProtKB/Swiss-Prot Q9W040 (OSM1_DROME)

Names and origin

Protein names

Recommended name:
    Intraflagellar transport protein osm-1
Alternative name(s):
    Osmotic avoidance abnormal protein 1 homolog

Gene names

Name:	osm-1
ORF Names:	CG13809

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1772 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for the maintenance and formation of cilia By similarity.
Subcellular location	Cell projection › cilium By similarity.
Sequence similarities	Belongs to the IFT172 family. Contains 13 TPR repeats. Contains 7 WD repeats.

Ontologies

Keywords
Cellular component	Cell projection Cilium
Domain	Repeat TPR repeat WD repeat
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW sensory cilium assembly Inferred from mutant phenotype. Source: FlyBase
Cellular component	cilium Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1772	1772	Intraflagellar transport protein osm-1		PRO_0000328946
Regions
	Repeat	14 – 53	40	WD 1
	Repeat	64 – 103	40	WD 2
	Repeat	110 – 150	41	WD 3
	Repeat	117 – 150	34	TPR 1
	Repeat	168 – 208	41	WD 4
	Repeat	212 – 250	39	WD 5
	Repeat	301 – 340	40	WD 6
	Repeat	537 – 575	39	WD 7
	Repeat	641 – 674	34	TPR 2
	Repeat	708 – 741	34	TPR 3
	Repeat	766 – 799	34	TPR 4
	Repeat	825 – 858	34	TPR 5
	Repeat	870 – 903	34	TPR 6
	Repeat	988 – 1021	34	TPR 7
	Repeat	1059 – 1092	34	TPR 8
	Repeat	1158 – 1184	27	TPR 9
	Repeat	1185 – 1217	33	TPR 10
	Repeat	1229 – 1268	40	TPR 11
	Repeat	1300 – 1333	34	TPR 12
	Repeat	1716 – 1751	36	TPR 13

Sequences

	Sequence		Length	Mass (Da)
	Q9W040-1 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 8CA197CCA86AC284	FASTA	1,772	197,785
	10 20 30 40 50 60 MQLKYLRTLL EGQEQIQRIA GLAWSPNQQR LAIATADRHI LLYDDAGERR DKFSTKPANP 70 80 90 100 110 120 ANGKNSYVIR GLAFSPDSTK LAVGQSDSIV YVYKLGESWN DKKVICNKFP QASAVTALIW 130 140 150 160 170 180 LTSGSIIAGK SPFPNEMNIF HQVFTTGLED GKVRALHSKS NKSQSLYGGD SICISLAANT 190 200 210 220 230 240 KGTGFLSGHN DGTIIRYFMT DEATEPLGRV VQHPVPPFAL AWPQGGFCAG GCDQRIVFYD 250 260 270 280 290 300 SMGRQLRTFD HSRTEGEREF TVAACSPNGQ AVAFGSFDRI RIFAWSPRQG AWSESATKEV 310 320 330 340 350 360 ACLYTLSSLL WRRDGARLAL GSVSGAVLLF ESVLRRTVWQ DKFELIFVAP SQLLVRSLTE 370 380 390 400 410 420 PSQALTIESQ LGLEIDDVRI MGRDNYLVAR TEESLILCDL TRNLSSEVPW TASGHHERFY 430 440 450 460 470 480 FENPTVCLIF NVGELSLVEY GENSILGSVR TEFVNPHVIS VRLNERGNAK ENKKLAFLLD 490 500 510 520 530 540 AKTICVVDLI SRMTSGQISH ETKIDWLELS ETAHKLLFRD KKLRLILVDN YTGKKQTLLS 550 560 570 580 590 600 NISFVQWVPQ SDVVVAQSNS NLAIWYNIDL PEHVTMQSVR GEAIEVLREN GRTVVRSQDG 610 620 630 640 650 660 PSEHNYQLDE GLVEFGTAVN DSDFGRAVHF LESLGDKPAA KAMWHNLALI ALEDGNLRVA 670 680 690 700 710 720 QRCYAALGNV SKAYYLAGMI QQADEFEESS GSPGILCPEV RAKLALLGSD LRTAERIYLE 730 740 750 760 770 780 QGDIESALKM YQQLGMWDEA VALAERRGYN RIAELKQQHM DYLLSSEQQE KAGQVLEEQG 790 800 810 820 830 840 DLQQAMSLYM KANKPARAAR LALKTPHILQ DEQVMLQVTE GLVRSELYEL AGDIAHRLSR 850 860 870 880 890 900 PEAALALYRK GGAYARALEI GRVVAPQEVT ALEEEWGDWL VSRKQLDASI NHYIEAGATQ 910 920 930 940 950 960 KALEAAVGAK QWRKAVQIAK VLDEPELIQR YAVDLAKHLA FAGDLDGAED MLVRANLHKD 970 980 990 1000 1010 1020 AIELLNRHGK WERAYLIGEK HLKAEQVREL FVQLAGTLEE QGKFRDAEKV LIAVNEPDLA 1030 1040 1050 1060 1070 1080 IAMYKRRELY DSMIRLVERY HKDLLDSTHL HLARQLESRG KLKNAEMHFV ASGDWKSAVH 1090 1100 1110 1120 1130 1140 MYCSSGRWED GYRVAKLKGT EGASQQVAYM WAKSMPTEGA VRLLSKLGLL DTAVGFACDS 1150 1160 1170 1180 1190 1200 GQFEFAMELC KFAGKPTDEV HLKIAMSLED EGKFEAAEAE FLKANKPREA ILMYQHAGDW 1210 1220 1230 1240 1250 1260 QAALNVAENH LPDAVGEVLI GQASAALETS NYKDYEALLL RAHRPDLIIE HYKQESLYED 1270 1280 1290 1300 1310 1320 ALRIAEEHYP SALNDLRRLQ AQLQRGQAQA QAGEDAASIS RSYLQKAAEF AKKEQFRKAA 1330 1340 1350 1360 1370 1380 ECLMQIDSSN AEDASTLERA LLRAAEICNQ FLEGQDAQEL AQSLGPRLLA IKQIGPAAQL 1390 1400 1410 1420 1430 1440 YLAADMPKQA VDVFIKTEQW SKARRLAKEI DPDLQLLAYV EQQQKASLKH EGNIEQLADI 1450 1460 1470 1480 1490 1500 DIVSALDLLA EHGEWQRCLE KAKGLNPALL QKYVAVYAAQ LIREGNCTTA LGLYLSYGAP 1510 1520 1530 1540 1550 1560 PIEAHFNIYT RIALDCLALR EEQTERGTTW RQLRDFLFRL LQSLKATPAQ SQTKFAASME 1570 1580 1590 1600 1610 1620 QFLLIAHYYA TRAACKEVQA LQPVALRLSL ALLRHTDLLP VDKGFYEAGM DLRQAGREAE 1630 1640 1650 1660 1670 1680 AFVMLNHYLD VCEAIEEGSG QLVDHSDLAS TDFPSSVPLP EDIHLKNDPS LHEEVREWVL 1690 1700 1710 1720 1730 1740 AVSMDQQVDQ QLPTDDRGLY ESSLGPNDLP CMLSGFPVRG RQPVTFQGSS NQVNRDVWSK 1750 1760 1770 FSVALKMSPG SGIADIISFT EKWQGAANYV MH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAF47619.2.
RefSeq	NP_647700.1.
UniGene	Dm.15839
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9W040.
Genome annotation databases
Ensembl	FBtr0072873; FBpp0072752; FBgn0035317; Drosophila melanogaster. [Genome view]
GeneID	38282.
KEGG	dme:Dmel_CG13809.
NMPDR	fig|7227.3.peg.7715.
Organism-specific databases
CTD	38282.
FlyBase	FBgn0035317. osm-1.
Phylogenomic databases
eggNOG	inNOG04745.
InParanoid	Q9W040.
OMA	NMAFIFL.
OrthoDB	EOG9WSWJB.
PhylomeDB	Q9W040.
Gene expression databases
ArrayExpress	Q9W040.
Bgee	Q9W040.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 2 hits. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	807842.

Entry information

Entry name

OSM1_DROME

Accession

Primary (citable) accession number: Q9W040

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project