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Reviewed, UniProtKB/Swiss-Prot Q9W032 (SGT1_DROME)

Last modified June 16, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein SGT1 homolog ecdysoneless
Gene names
Name: ecd
ORF Names: CG5714
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Required in both the follicle cells and the germline for oocyte development. Ref.4

Subcellular location

Cytoplasm. Ref.4

Tissue specificity

Expressed in the ecdysone-producing larval ring gland, nervous system, imaginal disks and gonads. Ref.4

Developmental stage

Expressed both maternally and zygotically throughout development. Ref.4

Sequence similarities

Belongs to the SGT1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 684684Protein SGT1 homolog ecdysoneless
PRO_0000220846

Experimental info

Mutagenesis6561P → S: Temperature-sensitive mutation; disrupts production of the steroid hormone ecdysone, causes developmental and reproductive defects. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9W032-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D59B5C943E352F30

FASTA68477,908
        10         20         30         40         50         60 
MSKIPGSNLE FVREEDFVEY YIFPKIPDNV QDEGALRKLM LQIRNEISAI VREKSLERSY 

        70         80         90        100        110        120 
LWHKDEFQLQ VRLGGAEERL LNEETNPEEE AELGDLPPHF HGVTHYGDNI SDEWFVVYLL 

       130        140        150        160        170        180 
TEITRARGDC IARVSDSDGE FLLIEAADAL PDWASPETCE QRVYLVGGHL QLLQNSAASS 

       190        200        210        220        230        240 
QDKPLTMAMA VQRIRMNPTL YRCSQEIQSC IDARLKEYQI AQPHFSIHRQ VLELPHSAAQ 

       250        260        270        280        290        300 
LLKQKPRLLS SAVRAFCERD SLDIKALRTM RYFPPEATRV RTNVRFTRCL YAMLSHQQYL 

       310        320        330        340        350        360 
PEKRLGWHLT DPVSEPERYK EQLLGLKLAS GLEILATQAK RVEGQQLEDL PAWRSYLRSL 

       370        380        390        400        410        420 
LSKGYFRDNI EGSAEYQELL NKAKVYFRGN QERFRTASRA GAEILDLLLH PAEAASEELR 

       430        440        450        460        470        480 
DEENNLQPSD SDEWLNISAE DLDSMLQDRY GPKKLYKPNG QMNAEEFTKQ LAEFLDRQSN 

       490        500        510        520        530        540 
YEGIEHRGLE EPELDSDDDE PPPQANGSTG LTAKVKKNPS MRKACQRNSV IQPEEPDSTH 

       550        560        570        580        590        600 
VRNFLDFVIP EDNWDSTSEM SDYADEDDME SNLNALSGGG SVFPLDRQIQ SYMEQMDREL 

       610        620        630        640        650        660 
AQTSVGKSFH GKKKTAPQAD EDDFDDIEDF EPININVNTL RNMMDSYQSQ VGGAGPVSNL 

       670        680 
FSAMGVGMSA VEDKEQKDIS ESAV 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[4]"Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis."
Gaziova I., Bonnette P.C., Henrich V.C., Jindra M.
Development 131:2715-2725(2004) [PubMed: 15128659] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF PRO-656.

Cross-references

Sequence databases

AE014296 Genomic DNA. Translation: AAF47628.1.
AY051483 mRNA. Translation: AAK92907.1.
RefSeqNP_647707.1.
UniGeneDm.4588

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9W032. 1 interaction.

Proteomic databases

PRIDEQ9W032.

Genome annotation databases

EnsemblFBgn0000543. Drosophila melanogaster. [Contig view]
GeneID38291.
KEGGdme:Dmel_CG5714.
NMPDRfig|7227.3.peg.7728.

Organism-specific databases

FlyBaseFBgn0000543. ecd.

Phylogenomic databases

HOGENOMQ9W032.
OMAQ9W032. LRACRVF.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-014817-MON.

Gene expression databases

ArrayExpressQ9W032.
GermOnlineCG5714. Drosophila melanogaster.

Family and domain databases

InterProIPR010770. SGT1.
[Graphical view]
PANTHERPTHR13060. SGT1. 1 hit.
PfamPF07093. SGT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio807890.

Entry information

Entry nameSGT1_DROME
AccessionPrimary (citable) accession number: Q9W032
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents