Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9VZW5 (FMAR_DROME)

Last modified June 16, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    FMRFamide receptor
      Short name=DrmFMRFa-R
      Short name=DFR
Alternative name(s):
    Larval opioid receptor
Gene names
Name: FR
Synonyms: FMRFaR
ORF Names: CG2114
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Hide | Top

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

A receptor for the FMRFamide peptides. Reacts with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. Ref.1 Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In larvae, expressed in trachea, brain, gut, fat body and Malpighian tubules. In adults, expressed in ovaries, heads and bodies. Ref.2

Developmental stage

Expressed throughout development; strongest in larvae and adults. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549FMRFamide receptor
PRO_0000069442

Regions

Topological domain1 – 117117Extracellular Potential
Transmembrane118 – 138211 Potential
Topological domain139 – 15820Cytoplasmic Potential
Transmembrane159 – 179212 Potential
Topological domain180 – 1812Extracellular Potential
Transmembrane182 – 202213 Potential
Topological domain203 – 23836Cytoplasmic Potential
Transmembrane239 – 259214 Potential
Topological domain260 – 28930Extracellular Potential
Transmembrane290 – 310215 Potential
Topological domain311 – 34131Cytoplasmic Potential
Transmembrane342 – 362216 Potential
Topological domain363 – 37614Extracellular Potential
Transmembrane377 – 397217 Potential
Topological domain398 – 549152Cytoplasmic Potential
Compositional bias461 – 47313Poly-Gly

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation931N-linked (GlcNAc...) Potential

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q9VZW5-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: AF449A9B0AD65104

FASTA54961,755
        10         20         30         40         50         60 
MSGTAVARLL LRLELPSPGV MPPPPTDYDY GGPISDDEFL ASAMATEGPT VRYDLFPQNN 

        70         80         90        100        110        120 
SQPTLQIVLN HTEVQTDLQY PHYEDLGLDP DPNWTRICED VYNPLLENNR IEFWVCGVLI 

       130        140        150        160        170        180 
NIVGVLGILG NIISMIILSR PQMRSSINYL LTGLARCDTV LIITSILLFG IPSIYPYTGH 

       190        200        210        220        230        240 
FFGYYNYVYP FISPAVFPIG MIAQTASIYM TFTVTLERYV AVCHPLKARA LCTYGRAKIY 

       250        260        270        280        290        300 
FIVCVCFSLA YNMPRFWEVL TVTYPEPGKD VILHCVRPSR LRRSETYINI YIHWCYLIVN 

       310        320        330        340        350        360 
YIIPFLTLAI LNCLIYRQVK RANRERQRLS RSEKREIGLA TMLLCVVIVF FMLNFLPLVL 

       370        380        390        400        410        420 
NISEAFYSTI DHKITKISNL LITINSSVNF LIYIIFGEKF KRIFLLIFFK RRLSRDQPDL 

       430        440        450        460        470        480 
IHYESSISNN GDGTLNHRSS GRFSRHGTQR STTTTYLVAT GGPGGGGCGG GGGNNSLNNV 

       490        500        510        520        530        540 
RLTQVSGSPG LVKIKRNRAP SPGPVVYFPA REMQRSASTT NSTTNNNTSI GYDWTLPDSK 


KLGHVSSGF

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of the first insect FMRFamide receptor."
Cazzamali G., Grimmelikhuijzen C.J.P.
Proc. Natl. Acad. Sci. U.S.A. 99:12073-12078(2002) [PubMed: 12218185] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
Strain: Canton-S.
Tissue: Larva.
[2]"Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor."
Meeusen T., Mertens I., Clynen E., Baggerman G., Nichols R., Nachman R.J., Huybrechts R., De Loof A., Schoofs L.
Proc. Natl. Acad. Sci. U.S.A. 99:15363-15368(2002) [PubMed: 12438685] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.

Hide | Top

Cross-references

Sequence databases

AF351129 mRNA. Translation: AAL83921.1.
BK000442 mRNA. Translation: DAA00378.1.
AE014296 Genomic DNA. Translation: AAF47700.1.
RefSeqNP_647758.1.
UniGeneDm.14721

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ9VZW5.

Genome annotation databases

EnsemblFBgn0035385. Drosophila melanogaster. [Contig view]
GeneID38357.
KEGGdme:Dmel_CG2114.
NMPDRfig|7227.3.peg.7822.

Organism-specific databases

FlyBaseFBgn0035385. FR.

Phylogenomic databases

HOGENOMQ9VZW5.
OMAQ9VZW5. MAFANGH.

Gene expression databases

ArrayExpressQ9VZW5.
GermOnlineCG2114. Drosophila melanogaster.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio808197.

Hide | Top

Entry information

Entry nameFMAR_DROME
AccessionPrimary (citable) accession number: Q9VZW5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents